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How does Rexulti work?

Medically reviewed by Last updated on Apr 12, 2019.

Official Answer


Rexulti (brexpiprazole) works by altering chemicals in the brain that can lead to schizophrenia or depression.

Rexulti is an atypical antipsychotic medication used to treat schizophrenia and used in combination with other medicines for the symptoms of major depressive disorder.

Rexulti is classified as a serotonin-dopamine activity modulator (SDAM) and works at serotonin and dopamine receptors in the brain. It is considered a second generation version of aripiprazole (Abilify), but has slightly different activity at the serotonin and dopamine receptors which may reduce certain side effects such as restlessness.


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