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User Reviews for Brexpiprazole

Also known as: Rexulti

Brexpiprazole has an average rating of 6.4 out of 10 from a total of 357 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 27% reported a negative effect.

Condition Avg. Rating Reviews Compare
Major Depressive Disorder  
6.3
200 reviews 47 medications
Depression  
7.0
116 reviews 78 medications
Schizophrenia  
5.6
41 reviews 49 medications
Summary of Brexpiprazole reviews 6.4 357 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Brexpiprazole

Kay February 12, 2021

Rexulti (brexpiprazole) for Major Depressive Disorder: “I used to endlessly read medication reviews for hours, just praying for a glimmer of hope in my future. It took me almost 2 years & many drugs until I was put on Rexulti, & it has honestly changed my life. I am happy, can take care of my children and most importantly I am not wanting to end my life anymore. I didn’t think a medication could help me. Depression is a very serious disease but there CAN be relief. It may not be Rexulti for you, your body chemistry may react better to something else, but please don’t give up hope and please take your meds as prescribed. For me I was mentally better in less than 1 week, but it can take up to 5. DON’T give up hope! A lot of people who get better don’t bother to go back & write reviews, therefore you see for tons of different meds tons of different bad reviews. I am a 33 year old woman diagnosed with severe severe depression and anxiety. Nothing else on the planet worked for me. Blessings and good luck.”

10 / 10
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Cboulanger86 · Taken for 1 to 6 months May 25, 2021

Rexulti (brexpiprazole) for Depression: “I have bi polar and have been in a depression for just over a year. I have zero energy and slept most of the day. I wasn't really interested in anything, I had no contact with people and only left house very minimally and gained literally 48 pounds. I tried Saphris for a few months and then my dr switched me to Abilify and that didn't help either. A month ago my dr switched me to Rexulti (I was also on wellbutrin the whole time and still am). So I have been on Rexulti and Wellbutrin for a month now. The1st week I started having a bit more energy and walked down the street and back every few days. The 2nd week I walked around the block and started eating better and stopped sleeping all day. The 3rd week I started contacting people agian. and going more places. It is week 4 and today I went for a long walk and then went to the beach for another walk. I sat out side all day for a bbq and I finally feel like myself. Everyone around me now notices that this past month I have consistently gotten better. This is the most stability I have had in a really long time.”

10 / 10
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Madalena February 28, 2020

Rexulti (brexpiprazole) for Depression: “I am a 22 year old female & have been diagnosed with MDD & anxiety. I was prescribed 0.5mgs Rexulti as an add-on to my 20mgs Prozac to alleviate lingering symptoms of depression, lack of motivation/energy,& anxiety. I felt relief from said symptoms the morning after the 3rd dose! Now, I'm excited to wake up in the morning & just live life. I have the perfect balance of happy energy & calmness that makes going to school, doing daily life things, hygiene & self-care tasks, & social activities enjoyable and fulfilling. My social anxiety is gone, I am bubbly & eager to engage with others, I am excited & motivated to do school work, & I quit having negative/self-betraying thoughts & behaviors. The only side affect experienced was an increased appetite for the first week of the medication, but that symptom subsided within a week. I know there are plenty of negative reviews on here, but I HIGHLY recommend giving it a try. I feel like I have my life/personality back.”

10 / 10
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Kr · Taken for 1 to 6 months August 22, 2020

Rexulti (brexpiprazole) for Depression: “Rexulti samples were given to me (for depression) by my doctor. It helped to some degree but in order to continue use,I had to fill my own prescription. The cost AFTER insurance is near $500. This is ridiculous. Pharmaceutical companies, the FDA, and all other entities who have their hand in pricing meds do not have patients best interest in mind. Their only concern is money. How disheartening that our country allows this. It's no wonder mental health in this country is where it is.”

1 / 10
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Genesis11 · Taken for 2 to 5 years June 17, 2019

Rexulti (brexpiprazole) for Depression: “I was prescribed Rexulti as an add on medication to several other antidepressants that I had been taking for several years. The other medications worked wonderfully for about 4 years but then I began to experience some relapse of depression and anxiety symptoms. and that is when my doc recommended I start on Rexulti. She started me on a low dose of .25mg/day and slowly worked up to the target dose of 2mg/day. It worked quickly (within 7 days) and I started to feel much better. It wiped out the depression and anxiety and I felt so normal and able to handle life. No side effects for me. I can still experience a normal range of emotions too.”

10 / 10
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Volleyqtpye · Taken for 1 to 6 months August 25, 2020

Rexulti (brexpiprazole) for Major Depressive Disorder: “I’ve never written a review of a drug before, but Rexulti has changed my life. I have tried just about every medication on the market for my MDD and nothing seemed to make much of a difference until Rexulti. Since the beginning I’ve seen a huge difference in my ability to control my urges which has helped tremendously with my eating disorder! My sadness and motivation has improved so much and I just find getting out of bed in the morning so much easier! I never thought I could feel like this!”

10 / 10
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Paxilman74 · Taken for less than 1 month December 19, 2019

Rexulti (brexpiprazole) for Major Depressive Disorder: “Been a week today, with 40mg of paxil and .5 rexulti. Best I have felt in 3 months. Don't give up! Took me 3 months of misery to feel close to myself again. Paxil quit its effectiveness after 19 yrs. Needed this boost, to claim my life back. Never stop fighting for mental health. Bless all that know the nightmare of anxiety and depression.”

9 / 10
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Frequently asked questions

Murph January 20, 2021

Rexulti (brexpiprazole) for Depression: “Hey Team, wish I could write a long post, but I'm limited here so I'll get to the point. I suffer from DP/DP/Anxiety, Depression. No SSRIs worked for me except for giving me side effects. I lost all hope last year. I took a gene test and I had MTFHR. I was suggested to take 15mg Deplin, 0.5mg rexulti, and 5mg of lexapro. It changed my life for the better. This drug kicked in very subtle and allowed me to grip my anxiety and get back to living.”

10 / 10
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sbout · Taken for less than 1 month October 3, 2020

Rexulti (brexpiprazole) for Depression: “I have been taking 2 mg Rexulti for 3 weeks now. My major depression has improved greatly. I now clean house, tend to my hygiene more, put on makeup, etc. I am interested in things again. Gained 4 lbs. but not sure it is because of the drug. My weight fluctuates anyway. I will give this a 10. It worked within 2 days.”

10 / 10
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Mel · Taken for 6 months to 1 year November 16, 2020

Rexulti (brexpiprazole) for Depression: “I suffered from severe postpartum anxiety and a year after I had my baby I was still having severe bouts of anxiety even with being on an SSRI. My NP added Rexulti to my SSRI and I’ve never looked back. It completely evened me out. No more dips with crying or being anxious out of my mind. It has been a lifesaver and I finally feel like me again. If you are reading this and you’re like I was and terrified to try it, all I can say is, I’m so glad I did. It may change your life.”

10 / 10
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Lilly · Taken for less than 1 month June 9, 2020

Rexulti (brexpiprazole) for Depression: “I struggled with anxiety and depression for 17 years since age 6. I tried every other medicine without success. Finally, with the help of the almighty, I have greatly improved on Rexulti. A real miracle!!”

10 / 10
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Matt · Taken for 1 to 6 months April 25, 2019

Rexulti (brexpiprazole) for Depression: “I was on Lexapro for many years, 20 mg/day. It helped with anxiety but not really for my depression. Began Rexulti and is started working within 2 days. I started at 0.5 mg and worked myself up to 2 mg/day. I have significantly increased energy and went from sleeping 8 hours to 6 hours a night. Mood has been better and activities seem doable and world is bright again. I seem to have less "dread" about life activities and feel happier, more energetic, and ready to tackle the world. No spasms, or other strange side effects.”

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T March 15, 2019

Rexulti (brexpiprazole) for Depression: “I’ve been on every Depression medication imaginable, none that worked totally. I was in a deep dark hole, fatigue, depression, paranoid. With being prescribed Rexulti in just a few days, I have my life back, I have all my energy back, depression is now hardly zero and my paranoia has diminished! No side effects for me! I recommend trying this to anyone suffering like I was!!”

10 / 10
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Gigi1902 · Taken for 1 to 6 months September 13, 2019

Rexulti (brexpiprazole) for Major Depressive Disorder: “I have been on Rexulti for more than 3 months now. I take wellbutrinxl (300mg), adderall (60mg), and rexulti( 4mg). This drug has help clear my depression and motivated me. This drug has given my life back. I can think clear, want to be around people and very motivated. I actually am pretty happy on this med. Yes, I have always struggled with my weight on meds. This is the first drug that I can take that I can loose weight on. I started weight watchers and lost 5lbs already.”

10 / 10
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Nobody · Taken for 6 months to 1 year November 19, 2020

Rexulti (brexpiprazole) for Depression: “I'm taking Rexulti for maybe a half year now. Realy helps me being less anxious, paranoid, depressed and my psychotic symptoms are gone! And I don't have any side effects! No weight gain or restless-legs like I used to have on other medications. For me, it really does help a lot.”

10 / 10
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Margo · Taken for less than 1 month August 20, 2019

Rexulti (brexpiprazole) for Depression: “I was diagnosed with panic disorder about 5 years ago. Under that umbrella includes agoraphobia, anxiety and depression, GAD and PTSD. I am a forensic pathologist and realize these come with the job. I started out on Zoloft and the absolutely awful Xanax (2.0 mg qd). After 3.5 yrs of self-prescribing with my family doctor I began seeing a psychiatrist. Over a year later I have been on Pristiq (100 mg) and Xanax (0.5 mg). I wasn’t feeling any better during this time and was given Buspar, Wellbutrin and Seroquel, none of which I took for more than a couple of days. I was zonked out from this mix. I began Rexulti one week ago and have seen incredible improvement in mood and energy. I’m only on the first baby step and am hoping this will help me wean off Xanax. I have not had any bad side effects so far and have actually lost weight. I’m already on a low sugar diet and gym at least three days a week. Keeping fingers crossed ”

7 / 10
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Belle · Taken for 1 to 2 years March 1, 2021

Rexulti (brexpiprazole) for Major Depressive Disorder: “I just want to say how amazing this drug is. I’ve been on antidepressants for most of my life. They stopped working at one point. My doctor added rexulti and I finally know what life is like without depression. This drug has honestly changed my life. I no longer deal with depression. I haven’t had any side effects from this medication whatsoever. I never usually write reviews, but I think it’s important people know how powerful this drug can be.”

10 / 10
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anxioustrynachill · Taken for 2 to 5 years December 16, 2019

Rexulti (brexpiprazole) for Major Depressive Disorder: “I’ve been on Rexulti (had Anxiety and Depression) for about two years now and it has been an absolute miracle for me. I had been on Zoloft for 5 years prior and had been on Abilify before switching to Rexulti. They both seem to be equally as affective in treating my anxiety and depression however instead of gaining weight (50 pounds on Abilify), I have lost 80 pounds and have almost no diet. Maybe not a good thing for all, but it was for me!”

10 / 10
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kris May 17, 2019

Rexulti (brexpiprazole) for Depression: “Hello! I am and 18 year old girl and I have a hell of a story. I was put on zoloft for a long time - maybe 3 years, so I started when I was 15 years old which was when I was diagnosed with depression. 3 years went by and I started getting worse and worse. They misdiagnosed me - I really had bipolar disorder so they then took me off the Zoloft cold turkey. Then they put me on Latuda and Lamictal. Latuda made me throw up 30 minutes after taking it, plus it didn't work. The lamictal did help my mood though, so they took me off Latuda. I felt so hopeless. That was until about a month and a half ago, when I was put on Rexulti and within a day of taking it, I felt so much better. No joke, this Rexulti is a miracle drug, everything has been so much better. It helps me feel balanced and I don't have severe episodes. It really calmed me down and made me happier. My only complaint is that I had a big appetite within the first two days of taking it. To those searching for a prescription that works- PLEASE at least TRY rexulti.”

9 / 10
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Kn · Taken for 1 to 6 months January 9, 2019

Rexulti (brexpiprazole) for Depression: “I never write reviews? But I feel this is totally necessary to tell how amazingly well this drug worked for me. I have had a horrible year. I’ve been on Prozac for 15 years and all of a sudden it stopped working. I switched to Zoloft and had relief for 5 months and that stopped working. My doctor prescribed rexulti and I’ve been on it for a month. I feel like I have my life back. I feel better than I have felt before even on Prozac. I started feeling better after 2 days and felt like myself again at 4 days. Zero side effects on this medication for me. It’s beyond worth a try.”

10 / 10
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Melfell · Taken for 6 months to 1 year June 1, 2020

Rexulti (brexpiprazole) for Depression: “Rexulti has been a MIRACLE for my anxiety/depression. I’ve tried pretty much every antidepressant on the market and had awful side effects with every one. I take lamictal for depression and adding this on top of it, it absolutely changed my life for the better. I have no side effects other than gaining a couple pounds, which I needed”

9 / 10
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ValerieS27 · Taken for 1 to 6 months May 30, 2021

Rexulti (brexpiprazole) for Depression: “I take 2 mg of Rexulti every night before bed for my bipolar disorder, and it has changed my life. I had tried so many medications and none of them seemed to help enough for me to find stability. Before I started it I was all over the place emotionally and struggled with severe anger and rage episodes multiple times a day. I've been on it for a few months now and I am much more in control of my emotions, whereas before I felt like my emotions totally controlled me. I'm happier and far more stable than I have been in years, and my relationship with my girlfriend, motivation, and ability to maintain my composure and work effectively have drastically improved with the help of Rexulti, therapy, and lifestyle adjustments.”

9 / 10
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Anonymous May 16, 2019

Rexulti (brexpiprazole) for Major Depressive Disorder: “Rexulti was very effective as far as helping pull me out of the dark hole that I was in, however the weight gain has been detrimental to my self esteem and caused me extreme frustration. For that reason and because I feel like this medication has made me very fatigued I’m coming off it. I have a huge fat bloated flabby stomach now and no matter how strict I diet I can not budge any of the weight. I have never experienced weight gain from a medication like this. To be clear I’m being completely honest about my diet. I’m not over eating I maintain a low carb high protein diet around 1500 calories a day and I weigh 200 lbs!!! I was in extremely good shape before and now I’m just a fat swollen blob. I get puffiness in my face and I feel unrecognizable. There is definitely some kind of fat storing and retention of water caused by this drug. I think this is a horrible medication because of this awful side effect. Anyone going thru depression certainly doesn’t need to be excessively fat.”

5 / 10
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A.j. · Taken for less than 1 month May 27, 2020

Rexulti (brexpiprazole) for Major Depressive Disorder: “I'm only on day 5 of .5 mg and I feel a significant difference. I had overwhelmed myself with responsibilities and crashed and burned, then had bottomed out completely, when another major event happened. I do not want to be on antidepressants again, after 15 years of them and 2 1/2 yrs off, but they are working. My anxiety was out of control and I was seriously sick because of Corona virus isolation and my stress. I hope it continues to work at low dose. I hope I don't gain huge amounts of weight. I do have a prescription that will slightly counteract the weight gain.”

10 / 10
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Beloved · Taken for less than 1 month May 10, 2019

Rexulti (brexpiprazole) for Depression: “This medicine is hard to rate. While taking it, I had never felt better. Seriously, my depression was gone, I felt like getting out again. I felt like I had my life back, BUT I began having cravings like I had never had before. I was eating uncontrollably. I was getting up in the middle of the night to eat. I have never had this behavior before and I'm in my 40's. In the past, if I began gaining weight, I immediately talked to the doctor and had my medication switched. However, this time, I was conflicted. The way I felt taking Rexulti felt like a miracle and I hated the idea of quitting, until.....I gained 70lbs!! I even gained 20 lbs in 3 days. I finally felt I had no choice but to stop Rexulti. I've been miserable for almost two years now. I've recently lost 23 lbs, but it has been so difficult. If I could go back, I would have switched after the first 10 lbs!! Sometimes, it feels like a no win situation. I'm committed to losing weight. I've got to do this!”

5 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.