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User Reviews for Brexpiprazole to treat Depression

Also known as: Rexulti

Brexpiprazole has an average rating of 7.0 out of 10 from a total of 92 ratings for the treatment of Depression. 60% of those users who reviewed Brexpiprazole reported a positive effect, while 20% reported a negative effect.

Brexpiprazole Rating Summary

7.0/10 average rating

92 ratings from 103 user reviews.

Compare all 189 medications used in the treatment of Depression.

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Reviews for Brexpiprazole

ValerieS27 · Taken for 1 to 6 months May 30, 2021

Rexulti (brexpiprazole): “I take 2 mg of Rexulti every night before bed for my bipolar disorder, and it has changed my life. I had tried so many medications and none of them seemed to help enough for me to find stability. Before I started it I was all over the place emotionally and struggled with severe anger and rage episodes multiple times a day. I've been on it for a few months now and I am much more in control of my emotions, whereas before I felt like my emotions totally controlled me. I'm happier and far more stable than I have been in years, and my relationship with my girlfriend, motivation, and ability to maintain my composure and work effectively have drastically improved with the help of Rexulti, therapy, and lifestyle adjustments.”

9 / 10
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Cboulanger86 · Taken for 1 to 6 months May 25, 2021

Rexulti (brexpiprazole): “I have bi polar and have been in a depression for just over a year. I have zero energy and slept most of the day. I wasn't really interested in anything, I had no contact with people and only left house very minimally and gained literally 48 pounds. I tried Saphris for a few months and then my dr switched me to Abilify and that didn't help either. A month ago my dr switched me to Rexulti (I was also on wellbutrin the whole time and still am). So I have been on Rexulti and Wellbutrin for a month now. The1st week I started having a bit more energy and walked down the street and back every few days. The 2nd week I walked around the block and started eating better and stopped sleeping all day. The 3rd week I started contacting people agian. and going more places. It is week 4 and today I went for a long walk and then went to the beach for another walk. I sat out side all day for a bbq and I finally feel like myself. Everyone around me now notices that this past month I have consistently gotten better. This is the most stability I have had in a really long time.”

10 / 10
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San Francusci · Taken for 2 to 5 years May 12, 2021

Rexulti (brexpiprazole): “I gained 60 lbs on Rexulti in 3 years.”

10 / 10
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Frequently asked questions

Madalena February 28, 2020

Rexulti (brexpiprazole): “I am a 22 year old female & have been diagnosed with MDD & anxiety. I was prescribed 0.5mgs Rexulti as an add-on to my 20mgs Prozac to alleviate lingering symptoms of depression, lack of motivation/energy,& anxiety. I felt relief from said symptoms the morning after the 3rd dose! Now, I'm excited to wake up in the morning & just live life. I have the perfect balance of happy energy & calmness that makes going to school, doing daily life things, hygiene & self-care tasks, & social activities enjoyable and fulfilling. My social anxiety is gone, I am bubbly & eager to engage with others, I am excited & motivated to do school work, & I quit having negative/self-betraying thoughts & behaviors. The only side affect experienced was an increased appetite for the first week of the medication, but that symptom subsided within a week. I know there are plenty of negative reviews on here, but I HIGHLY recommend giving it a try. I feel like I have my life/personality back.”

10 / 10
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Genesis11 · Taken for 2 to 5 years June 17, 2019

Rexulti (brexpiprazole): “I was prescribed Rexulti as an add on medication to several other antidepressants that I had been taking for several years. The other medications worked wonderfully for about 4 years but then I began to experience some relapse of depression and anxiety symptoms. and that is when my doc recommended I start on Rexulti. She started me on a low dose of .25mg/day and slowly worked up to the target dose of 2mg/day. It worked quickly (within 7 days) and I started to feel much better. It wiped out the depression and anxiety and I felt so normal and able to handle life. No side effects for me. I can still experience a normal range of emotions too.”

10 / 10
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Kr · Taken for 1 to 6 months August 22, 2020

Rexulti (brexpiprazole): “Rexulti samples were given to me (for depression) by my doctor. It helped to some degree but in order to continue use,I had to fill my own prescription. The cost AFTER insurance is near $500. This is ridiculous. Pharmaceutical companies, the FDA, and all other entities who have their hand in pricing meds do not have patients best interest in mind. Their only concern is money. How disheartening that our country allows this. It's no wonder mental health in this country is where it is.”

1 / 10
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Murph January 20, 2021

Rexulti (brexpiprazole): “Hey Team, wish I could write a long post, but I'm limited here so I'll get to the point. I suffer from DP/DP/Anxiety, Depression. No SSRIs worked for me except for giving me side effects. I lost all hope last year. I took a gene test and I had MTFHR. I was suggested to take 15mg Deplin, 0.5mg rexulti, and 5mg of lexapro. It changed my life for the better. This drug kicked in very subtle and allowed me to grip my anxiety and get back to living.”

10 / 10
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Mel · Taken for 6 months to 1 year November 16, 2020

Rexulti (brexpiprazole): “I suffered from severe postpartum anxiety and a year after I had my baby I was still having severe bouts of anxiety even with being on an SSRI. My NP added Rexulti to my SSRI and I’ve never looked back. It completely evened me out. No more dips with crying or being anxious out of my mind. It has been a lifesaver and I finally feel like me again. If you are reading this and you’re like I was and terrified to try it, all I can say is, I’m so glad I did. It may change your life.”

10 / 10
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sbout · Taken for less than 1 month October 3, 2020

Rexulti (brexpiprazole): “I have been taking 2 mg Rexulti for 3 weeks now. My major depression has improved greatly. I now clean house, tend to my hygiene more, put on makeup, etc. I am interested in things again. Gained 4 lbs. but not sure it is because of the drug. My weight fluctuates anyway. I will give this a 10. It worked within 2 days.”

10 / 10
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Lilly · Taken for less than 1 month June 9, 2020

Rexulti (brexpiprazole): “I struggled with anxiety and depression for 17 years since age 6. I tried every other medicine without success. Finally, with the help of the almighty, I have greatly improved on Rexulti. A real miracle!!”

10 / 10
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Matt · Taken for 1 to 6 months April 25, 2019

Rexulti (brexpiprazole): “I was on Lexapro for many years, 20 mg/day. It helped with anxiety but not really for my depression. Began Rexulti and is started working within 2 days. I started at 0.5 mg and worked myself up to 2 mg/day. I have significantly increased energy and went from sleeping 8 hours to 6 hours a night. Mood has been better and activities seem doable and world is bright again. I seem to have less "dread" about life activities and feel happier, more energetic, and ready to tackle the world. No spasms, or other strange side effects.”

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T March 15, 2019

Rexulti (brexpiprazole): “I’ve been on every Depression medication imaginable, none that worked totally. I was in a deep dark hole, fatigue, depression, paranoid. With being prescribed Rexulti in just a few days, I have my life back, I have all my energy back, depression is now hardly zero and my paranoia has diminished! No side effects for me! I recommend trying this to anyone suffering like I was!!”

10 / 10
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Nobody · Taken for 6 months to 1 year November 19, 2020

Rexulti (brexpiprazole): “I'm taking Rexulti for maybe a half year now. Realy helps me being less anxious, paranoid, depressed and my psychotic symptoms are gone! And I don't have any side effects! No weight gain or restless-legs like I used to have on other medications. For me, it really does help a lot.”

10 / 10
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Margo · Taken for less than 1 month August 20, 2019

Rexulti (brexpiprazole): “I was diagnosed with panic disorder about 5 years ago. Under that umbrella includes agoraphobia, anxiety and depression, GAD and PTSD. I am a forensic pathologist and realize these come with the job. I started out on Zoloft and the absolutely awful Xanax (2.0 mg qd). After 3.5 yrs of self-prescribing with my family doctor I began seeing a psychiatrist. Over a year later I have been on Pristiq (100 mg) and Xanax (0.5 mg). I wasn’t feeling any better during this time and was given Buspar, Wellbutrin and Seroquel, none of which I took for more than a couple of days. I was zonked out from this mix. I began Rexulti one week ago and have seen incredible improvement in mood and energy. I’m only on the first baby step and am hoping this will help me wean off Xanax. I have not had any bad side effects so far and have actually lost weight. I’m already on a low sugar diet and gym at least three days a week. Keeping fingers crossed ”

7 / 10
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Kat · Taken for 1 to 6 months April 22, 2021

Rexulti (brexpiprazole): “I'm rating this a 10 because I've never had a med work so well on my bipolar depression and the effect was immediate! I can do things again with ease and not steady. I couldn't even get outta bed most days now I'm up early I shower and take care of myself, see friends, do hobbies like painting writing and exercising. I laugh again and it felt like a light switch turned on in my brain. Very thankful for this medication. I take along with lamictal.”

10 / 10
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kris May 17, 2019

Rexulti (brexpiprazole): “Hello! I am and 18 year old girl and I have a hell of a story. I was put on zoloft for a long time - maybe 3 years, so I started when I was 15 years old which was when I was diagnosed with depression. 3 years went by and I started getting worse and worse. They misdiagnosed me - I really had bipolar disorder so they then took me off the Zoloft cold turkey. Then they put me on Latuda and Lamictal. Latuda made me throw up 30 minutes after taking it, plus it didn't work. The lamictal did help my mood though, so they took me off Latuda. I felt so hopeless. That was until about a month and a half ago, when I was put on Rexulti and within a day of taking it, I felt so much better. No joke, this Rexulti is a miracle drug, everything has been so much better. It helps me feel balanced and I don't have severe episodes. It really calmed me down and made me happier. My only complaint is that I had a big appetite within the first two days of taking it. To those searching for a prescription that works- PLEASE at least TRY rexulti.”

9 / 10
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Kn · Taken for 1 to 6 months January 9, 2019

Rexulti (brexpiprazole): “I never write reviews? But I feel this is totally necessary to tell how amazingly well this drug worked for me. I have had a horrible year. I’ve been on Prozac for 15 years and all of a sudden it stopped working. I switched to Zoloft and had relief for 5 months and that stopped working. My doctor prescribed rexulti and I’ve been on it for a month. I feel like I have my life back. I feel better than I have felt before even on Prozac. I started feeling better after 2 days and felt like myself again at 4 days. Zero side effects on this medication for me. It’s beyond worth a try.”

10 / 10
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Melfell · Taken for 6 months to 1 year June 1, 2020

Rexulti (brexpiprazole): “Rexulti has been a MIRACLE for my anxiety/depression. I’ve tried pretty much every antidepressant on the market and had awful side effects with every one. I take lamictal for depression and adding this on top of it, it absolutely changed my life for the better. I have no side effects other than gaining a couple pounds, which I needed”

9 / 10
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Liz October 20, 2020

Rexulti (brexpiprazole): “I was taking Rexulti for about 8 months. At first it was amazing and all of a sudden everything went down hill. I will NEVER go back on the drug. It made me extremely depressed, suicidal and reckless. It put me in a mental hospital because how dark my mood went. This medication is awful!!!!”

1 / 10
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sel · Taken for 6 months to 1 year June 24, 2020

Rexulti (brexpiprazole): “Ive been using rexulti for bipolar treatment since November 2019 and it has changed my life. My bipolar is so much easier to control now. I finally feel like my real self gets to make my decisions instead of my emotional self. I have done lots of counselling as well but the medication has been the most helpful. I can control my urges and sadness better. I don’t get majorly depressed or manic anymore. Rexulti was my life saver. cons: experienced some dizziness at the start but it went away, can’t cry ever, expensive without coverage.”

9 / 10
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Beloved · Taken for less than 1 month May 10, 2019

Rexulti (brexpiprazole): “This medicine is hard to rate. While taking it, I had never felt better. Seriously, my depression was gone, I felt like getting out again. I felt like I had my life back, BUT I began having cravings like I had never had before. I was eating uncontrollably. I was getting up in the middle of the night to eat. I have never had this behavior before and I'm in my 40's. In the past, if I began gaining weight, I immediately talked to the doctor and had my medication switched. However, this time, I was conflicted. The way I felt taking Rexulti felt like a miracle and I hated the idea of quitting, until.....I gained 70lbs!! I even gained 20 lbs in 3 days. I finally felt I had no choice but to stop Rexulti. I've been miserable for almost two years now. I've recently lost 23 lbs, but it has been so difficult. If I could go back, I would have switched after the first 10 lbs!! Sometimes, it feels like a no win situation. I'm committed to losing weight. I've got to do this!”

5 / 10
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GradStudent048 · Taken for 1 to 2 years May 25, 2020

Rexulti (brexpiprazole): “I’m back! I posted nearly 2 years ago on July 5, 2018 when I had been on Rexulti for a month. This drug helped me a lot the first few months, and then things just started going downhill. I gained 40 pounds in a matter of about 9 months, and I’m finally at a place now where my psychiatrist and I agree that I don’t need this medication anymore. The weight gain has just been really detrimental for my mental health because body image and eating disorders were part of my triggers. I hope that this medication can help other people and they don’t have to suffer with it fizzling out and causing unprecedented weight gain like it did for me.”

5 / 10
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Greenbean · Taken for 1 to 6 months October 1, 2020

Rexulti (brexpiprazole): “I was taking Zoloft for depression and Rexulti was added to it. At first I felt great but after about 2 weeks I became very reckless. I didn’t care about anything. I didn’t care about Ccnsequences of my actions. I did lots of stupid stuff. I stopped taking it.”

2 / 10
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Anonymous · Taken for 1 to 6 months May 27, 2020

Rexulti (brexpiprazole): “I started on Rexulti at the low dose of 0.5 mg. It was really helping with my break through depression. I have been taking Wellbutrin for about 2 years and I needed a little boost. Well 2 months later and I gained 10 POUNDS. Super disappointed. The medication works, but be ready to be depressed about how much weight you've gained from it. Won't recommend.”

4 / 10
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Ag · Taken for 1 to 6 months March 27, 2020

Rexulti (brexpiprazole): “This medication saved my life. My anxiety was so bad I couldn't take an effective dose of SSRI. Rexulti calmed my anxiety enough I was able to start upping my SSRI and my depression is getting better and better every day. My anxiety is almost nonexistent! I have gained a few pounds but nothing significant and I would rather gain 10 pounds and be happy than be miserable.”

9 / 10
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SAMMM · Taken for 1 to 6 months March 31, 2021

Rexulti (brexpiprazole): “I have been on this medication for about 4 months now. Having been through literally double digits on trying medications I was reluctant and didn't have high hopes. My diagnosis is BPD and BP1. The combination along with BP1 being treatment resistant I had low hope in actually finding something that worked. Within the first week of taking Rexulti it felt that mental clouds began to part and I could start to see the sun coming through. Skip ahead a few months later and I am living virtually depression and anxiety free along with minimal manic episodes. I started at 0.5 mg for a week and I now take 1mg daily. This medication was a literal life saver and also the reason I no longer self harm. Only side note/side effect I have had is some weight gain and some tremors when I first wake up in the morning. Otherwise no other issues.”

9 / 10
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Justkeepswimming · Taken for less than 1 month September 12, 2016

Rexulti (brexpiprazole): “I am on my 3rd week of Rexulti. My doctor gave it to me for major anxiety and depression. My depression is gone and my anxiety is 80 percent better. My pmdd is even better, I no longer walk around under this dark cloud not wanting to live. I can't take ssris. Every med I have been given didn't work or made me suicidal or gave me every side effect in the book. I was scared first trying this because of my usual reactions to medicines, and the fact that it is an a antipsychotic freaked me out. Only side effects are jaw pain, hungry all of the time but haven't gained weight yet. I feel so much better. This medicine saved me! (Knock on wood). Give it a try. By the way, I take it alone.”

9 / 10
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Justagirl · Taken for 1 to 6 months December 11, 2018

Rexulti (brexpiprazole): “I've been on Rexulti for about 5 months now. I told myself I would write a review because I know there are people out there looking for hope and good reviews. This drug definitely took me out of a dark hole. It took 3 days for it to work. I remember waking up feeling normal again. I take it as an add on to my anti-depressant Mirtazapine. I gained weight at the beginning but I was able to shed it off shortly after. I have some extrapyramidal effects but nothing weird. I just feel a weird twitch in a muscle every now and then. I keep an eye on it though. Other than that, no other bad side effects. I would give it a chance if your anti-depressant isn't doing enough. I take 1mg.”

10 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.