Skip to Content

User Reviews for Brexpiprazole to treat Schizophrenia

Also known as: Rexulti

Brexpiprazole has an average rating of 5.6 out of 10 from a total of 37 ratings for the treatment of Schizophrenia. 46% of reviewers reported a positive effect, while 41% reported a negative effect.

Brexpiprazole Rating Summary

5.6/10 average rating

37 ratings from 41 user reviews.

Compare all 80 medications used in the treatment of Schizophrenia.

10
22%
9
11%
8
14%
7
5%
6
5%
5
3%
4
0%
3
5%
2
3%
1
32%

Reviews for Brexpiprazole

SAJ · Taken for 6 months to 1 year May 17, 2020

Rexulti (brexpiprazole): “I have had to opposite experience than others on this site. I was on Abilify for about 10 years after trying every 2nd gen anti psychotic. I also have Trauma PTSD. Anyway at some point abilify stopped working well and I became extremely manic and aggressive. I completely stopped sleeping. Honestly just stayed up all night sitting in a chair being weird and catatonic with racing thoughts. When I rarely fell asleep it would only be for a couple hrs. Dr. switched me to Rexulti because of studies showing it helps with PTSD and within 3 days I felt so so much better. I was less paranoid, less agitated, no voices, no paralysis, no EPS. Way better than Abilify ever was. I also started to sleep 6-8 hrs straight every night. It is like it just reset something in my brain and I began to sleep again. I guess it either really works for you or really doesn't.”

10 / 10
Was this helpful?YesNo
Kaya · Taken for 6 months to 1 year December 4, 2019

Rexulti (brexpiprazole): “This drug has almost completely halted all hallucinations (I have Schizoaffective disorder). To my knowledge I am not delusional and I seem to be able to follow conversations better. I have tried 5 other antipsychotics and none were even half as effective. Also I HAVE NO SIDE EFFECTS!!!! 6 months in and I will never go off. 4mg daily”

10 / 10
Was this helpful?YesNo
Shell · Taken for 1 to 6 months July 4, 2019

Rexulti (brexpiprazole): “My daughter was taking abilify for 6 yrs and they switched her to this drug Rexulti because they said it had less weight gain issues. At first it work great for about 8 weeks then just stopped working. She developed hiccups on and off with this med and her body temperature was going hit and cold she then became very confused and could not focus then extremely depressed and I took her to the emergency room where 16 hrs later she had a grand mal seizure. Don’t take this Med I don’t think they’ve done enough research on it and it is still to new. My daughter was in the hospital 2 1/2 weeks and still is unable to think properly or focus on anything and still experiencing hiccups on and off now. I hope and pray she recovers. She was in college getting straight A’s before this.”

1 / 10
Was this helpful?YesNo
Donna mar December 29, 2016

Rexulti (brexpiprazole): “I was taking this for ADD .right now I had to stop taking it the doc was giving me samples n I ran out waiting for my insurance co to give the ok . This med has changed my life. My thinking is very scattered like there's a radio on in my head. It's like the rexulti shut the radio off I can think so clear. My thinking is not jumping around When I am on it.I look forward to things Not bored. Want to try new things. Organizing comes so easy”

10 / 10
Was this helpful?YesNo
Lee · Taken for 1 to 6 months September 7, 2020

Rexulti (brexpiprazole): “This medication worked well for reducing my general anxiety and making me feel much better and have a clearer mind and less moody, I take it for Bipolar w/ differential diagnosis PTSD. My only complaint is I have minor auditory hallucinations. They don't bother me enough to change medication as I've tried Seroquel, Geodon, Wellbutrin, Abilify, lithium, Prozac, Lexapro, Latuda, and have been on Lamictal for years. The Latuda worked best but insurance won't cover it. The auditory hallucinations are things like my cat meowing, my phone alarm going off, and my name being said. It's a good medication, I still have anxiety that is so bad I have considered ordering groceries and other things exclusively online because I still get extremely anxious around people.”

6 / 10
Was this helpful?YesNo
June · Taken for 2 to 5 years March 19, 2019

Rexulti (brexpiprazole): “Go ahead and take this medicine if want to mentally feel better but be prepared to gain 30 pounds and never be able to lose it. Honestly, I don't recommend it at all because the weight gain has ruined my life. Good luck in whatever you decide to do.”

5 / 10
Was this helpful?YesNo
Jylo · Taken for less than 1 month December 11, 2018

Rexulti (brexpiprazole): “Since starting Rexulti a week & a half ago I've been feeling more motivated, I have more energy & I feel less irritable. I'm studying more productively. I haven't been experiencing intrusive thoughts - obviously I can remember what they were, therefore they still enter my mind, but they're not distressing & they don't linger. So, ultimately I feel 'normal' again i.e. without illness or side effects. (I'm still overweight & I still procrastinate, but since beginning this new treatment I have the motivation & energy to transform to the person I want to be).”

8 / 10
Was this helpful?YesNo

Frequently asked questions

Coryman616 · Taken for 1 to 6 months August 25, 2018

Rexulti (brexpiprazole): “Rexulti is the first anti-psychotic I've been on with no apparent side effects. It has my schizophrenia under control and has completely gotten rid of my voices. It also helps control my paranoia, psychosis, and helps with my gut-wrenching anxiety so I can get out of my apartment and lead a normal life. I have nothing but good things to say about Rexulti.”

10 / 10
Was this helpful?YesNo
Pes · Taken for less than 1 month August 28, 2019

Rexulti (brexpiprazole): “I've been taking Rexulti for a 3-4 weeks. I'm a bit cranky all the time, always moody. But the PTSD has gone, and I'm thinking clearer. I still have anxious thoughts but they have always been there. My paranoia is controlled by CBT and reiterating soothing thoughts. I feel more motivated to study and procrastinate less. I have more hours in a day because I can wake up at 5am.”

Was this helpful?YesNo
Mmaryland June 26, 2017

Rexulti (brexpiprazole): “Rexulti has helped my bipolar mania in so many way. From previous experience with antipsychotics, I was expecting side effects like increased appetite, excessive sleepiness, etc. I did get akathisia when I first began, but I did begin at 3mg (a high dose). I reduced back down to 0.5 and gradually increased to 1mg. So far (1.5 months), I have seen extreme improvement in my mood and sleep schedule. I feel more motivated and am getting more of my responsibilities done. My social anxiety is pretty much gone as is my GAD. The only issues I have is periodically having trouble falling asleep, but this is not significant. Overall, I think Rexulti has really helped me in many ways and I attribute the positive results in my recent life to Rexulti”

Was this helpful?YesNo
Dissapointed · Taken for 1 to 6 months March 2, 2017

Rexulti (brexpiprazole): “I am not sure how many months I have been on this medication, but while I have been on it I have managed to gain almost 10 pounds. I do not feel like I over-eat either. The weight just seems to pile on. I feel incredibly sleepy during the day. So much so that on most days I take a long nap. I have very little energy. My stomach seems to bloat out more. Otherwise I seem to be doing just fine, both mentally and physically. So if you don't mind being fat, lazy, and lifeless; but not crazy; this might just be the drug for you!”

6 / 10
Was this helpful?YesNo
Kutiekatie22 · Taken for 1 to 2 years August 10, 2016

Rexulti (brexpiprazole): “This was a game changing medication for me. I was diagnosed schizoaffective, later changed to bipolar 1. I was a zombie from the medication combination I used to be on, zyprexa and depakote. Changing the zyprexa to rexulti gave me my life back. At first, it gave me side effects of dizziness and anxiety, but after stopping and trying again, its given me energy, concentration, and the mood swings and psychosis stopped. I'm very happy with this medication. I just upped the dosage from 2mg to 3mg after being on it for a year and a half.”

9 / 10
Was this helpful?YesNo
davos777 · Taken for less than 1 month February 27, 2018

Rexulti (brexpiprazole): “Rexulti seems too be a good medicine so far. After one week my paranoia is almost gone. I do notice a speedy effect which has caused me too be more active. This is actually good because rexulti is helping me too get out of the house and avoid some social phobia issues. I would definitely recommend this med if you have any kind of paranoia associated with bipolar depression. Tommorow the 7th day I will increase too one mg. Lets hope this med continues too work .Thanks and good luck. Ps I have been on many meds and hated most all atypical antipsychotics.”

8 / 10
Was this helpful?YesNo
Saysay · Taken for 1 to 6 months May 8, 2019

Rexulti (brexpiprazole): “I was on zyprexa for 9 years no issues them. I had Tardive dyskinesia . I was put on rexulti it worked for about a month got me out of the withdrawals of zyprexa but the rexulti gave me hot flashes every night so bad I had panic attacks on top of it I had extremely angry outburst for no reason I also had self harm behaviors during the outbursts. I stopped the medication as soon as I realized what it was doing to me. This is a scary medication”

1 / 10
Was this helpful?YesNo
Dipodo September 12, 2018

Rexulti (brexpiprazole): “Rexulti/Brexpiprazole has been amazing for my lifestyle while dealing with Schizophrenia. When I was on Risperidone, I was having trouble getting up for work, and was getting to work late at 10-10.30am. I also had two episodes of acute Schizophrenia on a low dose Risperidone over 4 years. The side effects on a higher dose of risperidone made me feel lethargic and tired all day. However, on an equivalent dose of Rexulti, the voices are not there anymore. Intrusive thoughts are more controlled. And I get up early enough in the morning to get to work by 8.30-9! Has happened for two weeks now, and I'm pretty sure this will continue, because I don't feel the same lethargy as I did on risperidone. So in effect, I'm on a relatively high dose, but the side effects are much lower than risperidone. I am really happy with the results.”

10 / 10
Was this helpful?YesNo
cobweb · Taken for 1 to 6 months May 17, 2018

Rexulti (brexpiprazole): “Rexulti has stopped my delusions and obsessive ruminationing where Seroquel XR amongst others failed, and in the short period of time I have been on this drug, it has also mostly taken away my extreme paranoid anxiety, which was unrelenting. My brain is quiet and calm. A slight opiate like warmth and peace of mind. It is lifting a depressive episode, in a much smoother, mild way compared to my experience on Effexor XR. No akathisia. I am not sure if my sleep is affected because I have always had sleep issues regardless. I am prescribed a little Temazepam to sleep if needed. A slight headache for a few days upon starting, no nausea. No weight gain. Very pleased with how this is working so far.”

8 / 10
Was this helpful?YesNo
GILDTHEKAYA May 20, 2021

Rexulti (brexpiprazole): “I have schizoaffective disorder. For a long time I thought Rexulti was a miracle. Over time though I started having metabolic problems and my psychiatric symptoms returned, albeit altered. I had to quit due to medical reasons, and when I did I did not have a major psychotic episode, my condition improved. Given that the medical industry has shown repeatedly that they do not have patients best interests at heart, (they are capitalist enterprises focused solely on profit, any benefit to the patient is ancillary and useful only for marketing purposes.) I see it as a hallmark of a good patient-doctor relationship that a good faith effort is made by both parties toward a clear understanding of risks, mechanisms of action, and other relevant information.”

3 / 10
Was this helpful?YesNo
PeaceLoveHappiness December 17, 2015

Rexulti (brexpiprazole): “I was taking risperdal before this but that made me too lethargic and have loss of interest in everything. Rexulti has helped me with my bipolar and mild schizophrenia. I take 2mg/day. I only had minor side effects like headaches and upset stomach the first week which faded away. I also take Celexa 40mg a day which I have been on for a year. The first few months it worked great but these past few months it doesn't seem to be working. I'm considering cutting down to 20mg/day of celexa because I think the combination of these drugs is too strong for me.”

8 / 10
Was this helpful?YesNo
Suzanne L June 17, 2017

Rexulti (brexpiprazole): “for the first week I took this, I had some nausea and very intense sleepiness that made me take one and even 2 naps during the day. But I changed the time of day I took it and that seemed to help. For the first month I was sooo happy, and a lot less delusional. I'm not quite sure where it all went wrong. Now, my delusions have worsened, I've developed an intense phobia of driving and being in a car in general. I have many intrusive thoughts and honestly I'm considering stopping it. Which sucks because it worked there for awhile. I wouldn't say don't take this medicine, but pay attention to your body and be wary of any anxiety you're experiencing and talk to your doctor to get a handle on it before it gets out of hand.”

Was this helpful?YesNo
Jameelah1 · Taken for 1 to 6 months December 7, 2017

Rexulti (brexpiprazole): “I am on a dose of 4 mg. I feel very pleased about this medication. It is very quiet, no voices. I have been on the medication for 2 months. I was gradually introduced to a higher and higher dose. At 4 mg., I am finally not afraid from the thoughts I have that are delusions. I do have an increase in appetite, and a bit of restlessness. But the benefits of this medicine far outweigh any adverse effects. I am not anxious as bad as I was either. And I can get up and take care of housework better. I am liking this med very much.”

Was this helpful?YesNo
MJR · Taken for less than 1 month July 1, 2021

Rexulti (brexpiprazole): “I have Schizotypal personality disorder and for the first time in my life I can see what's around me without feeling I'm looking at a picture. I don't melt down over scary things or feel the constant state of danger anymore. My mind is calm and I can focus on the present instead of being overwhelmed by traumas from long ago. I do have mild hunger all the time but I can live with that. I'm following a diabetic diet plan to prevent weight gain just in case. This medicine is a real blessing”

9 / 10
Was this helpful?YesNo
Nsjsn · Taken for less than 1 month March 18, 2020

Rexulti (brexpiprazole): “Please do NOT take this medication Rexulti it will make you feel horrid and inhuman and it doesn't stop. I was given it for Schizoaffective disorder. Be ready to be in pain. It has been a solid week now of no rexulti and I still feel like I'm on it and can't escape this nightmare.”

1 / 10
Was this helpful?YesNo
james youngfellow · Taken for 1 to 2 years April 8, 2018

Rexulti (brexpiprazole): “I tapered off Haldol and took this medicine. By itself it does no good and sent me to the mental hospital. They gave me Haldol along with Rexulti and since then it has been very good. I don't even hardly think about a hallucination or delusion anymore much less experience them.”

9 / 10
Was this helpful?YesNo
Sarah November 27, 2018

Rexulti (brexpiprazole): “Chest pains, headaches galore. Not to mention my memory has been horrible and my legs have been very restless. Thursday (11/22/18) I was relaxing, calm. But then there was a ringing in my ears as there had been everyday 3 days prior. I began to feel like I was dying, which was me beginning to panic due to the effects I've been having. I haven't had health anxiety since I was 8 years old. I'm 18 now, but never this bad. I began to get agitated very quickly and I couldn't stop moving. I was pacing around my house, moving my legs, rocking back and forth and threatening my parents as I grew more agitated and feeling like I was in a cage. I could not get in touch with my prescriber so I had to go to the ER. Eventually, I got tired and it subsided so I did not need the sedative the hospital staff wanted to give me. Blood work, EKG and urine test all fine. I've been on it for roughly 6-8 weeks and it stopped working.”

3 / 10
Was this helpful?YesNo
Truck · Taken for less than 1 month May 3, 2021

Rexulti (brexpiprazole): “For me this medication did not work . This medication made me extremely reckless and impulsive. It changed my paranoid thoughts into rage towards whatever I was thinking. I'm glad that I know I'm paranoid because I feel if I believed what I'm experiencing I would not be free writing this. I'm glad this helps some people but not for me.”

1 / 10
Was this helpful?YesNo

This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

Learn more about Schizophrenia

IBM Watson Micromedex

Symptoms and treatments

Drugs.com Health Center

Mayo Clinic Reference