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User Reviews for Brexpiprazole to treat Major Depressive Disorder

Brand names: Rexulti

Brexpiprazole has an average rating of 6.3 out of 10 from a total of 214 reviews for the treatment of Major Depressive Disorder. 51% of reviewers reported a positive experience, while 28% reported a negative experience.

Brexpiprazole rating summary

6.3/10 average rating

214 ratings from 227 user reviews.

Compare all 57 medications used in the treatment of Major Depressive Disorder.

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17%
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10%
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3%
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7%
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5%
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Reviews for Brexpiprazole

Kay · February 12, 2021

Rexulti (brexpiprazole) "I used to endlessly read medication reviews for hours, just praying for a glimmer of hope in my future. It took me almost 2 years & many drugs until I was put on Rexulti, & it has honestly changed my life. I am happy, can take care of my children and most importantly I am not wanting to end my life anymore. I didn’t think a medication could help me. Depression is a very serious disease but there CAN be relief. It may not be Rexulti for you, your body chemistry may react better to something else, but please don’t give up hope and please take your meds as prescribed. For me I was mentally better in less than 1 week, but it can take up to 5. DON’T give up hope! A lot of people who get better don’t bother to go back & write reviews, therefore you see for tons of different meds tons of different bad reviews. I am a 33 year old woman diagnosed with severe severe depression and anxiety. Nothing else on the planet worked for me. Blessings and good luck."

10 / 10
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Paxil... · Taken for less than 1 month · December 19, 2019

Rexulti (brexpiprazole) "Been a week today, with 40mg of paxil and .5 rexulti. Best I have felt in 3 months. Don't give up! Took me 3 months of misery to feel close to myself again. Paxil quit its effectiveness after 19 yrs. Needed this boost, to claim my life back. Never stop fighting for mental health. Bless all that know the nightmare of anxiety and depression."

9 / 10
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Volle... · Taken for 1 to 6 months · August 25, 2020

Rexulti (brexpiprazole) "I’ve never written a review of a drug before, but Rexulti has changed my life. I have tried just about every medication on the market for my MDD and nothing seemed to make much of a difference until Rexulti. Since the beginning I’ve seen a huge difference in my ability to control my urges which has helped tremendously with my eating disorder! My sadness and motivation has improved so much and I just find getting out of bed in the morning so much easier! I never thought I could feel like this!"

10 / 10
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Frequently asked questions

Gigi · Taken for 1 to 6 months · September 13, 2019

Rexulti (brexpiprazole) "I have been on Rexulti for more than 3 months now. I take wellbutrinxl (300mg), adderall (60mg), and rexulti( 4mg). This drug has help clear my depression and motivated me. This drug has given my life back. I can think clear, want to be around people and very motivated. I actually am pretty happy on this med. Yes, I have always struggled with my weight on meds. This is the first drug that I can take that I can loose weight on. I started weight watchers and lost 5lbs already."

10 / 10
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Belle · Taken for 1 to 2 years · March 1, 2021

Rexulti (brexpiprazole) "I just want to say how amazing this drug is. I’ve been on antidepressants for most of my life. They stopped working at one point. My doctor added rexulti and I finally know what life is like without depression. This drug has honestly changed my life. I no longer deal with depression. I haven’t had any side effects from this medication whatsoever. I never usually write reviews, but I think it’s important people know how powerful this drug can be."

10 / 10
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Are you taking this medicine?

anxio... · Taken for 2 to 5 years · December 16, 2019

Rexulti (brexpiprazole) "I’ve been on Rexulti (had Anxiety and Depression) for about two years now and it has been an absolute miracle for me. I had been on Zoloft for 5 years prior and had been on Abilify before switching to Rexulti. They both seem to be equally as affective in treating my anxiety and depression however instead of gaining weight (50 pounds on Abilify), I have lost 80 pounds and have almost no diet. Maybe not a good thing for all, but it was for me!"

10 / 10
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Anonymous · May 16, 2019

Rexulti (brexpiprazole) "Rexulti was very effective as far as helping pull me out of the dark hole that I was in, however the weight gain has been detrimental to my self esteem and caused me extreme frustration. For that reason and because I feel like this medication has made me very fatigued I’m coming off it. I have a huge fat bloated flabby stomach now and no matter how strict I diet I can not budge any of the weight. I have never experienced weight gain from a medication like this. To be clear I’m being completely honest about my diet. I’m not over eating I maintain a low carb high protein diet around 1500 calories a day and I weigh 200 lbs!!! I was in extremely good shape before and now I’m just a fat swollen blob. I get puffiness in my face and I feel unrecognizable. There is definitely some kind of fat storing and retention of water caused by this drug. I think this is a horrible medication because of this awful side effect. Anyone going thru depression certainly doesn’t need to be excessively fat."

5 / 10
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Missy · Taken for 2 to 5 years · July 19, 2019

Rexulti (brexpiprazole) "I've tried SO many meds and combinations over the last 30 years for MDD, Anxiety and Agoraphobia. I also tried ECT. I never felt better than the combination of Wellbutrin, Pristiq and Rexulti. Even managed to stop using Xanax and stop drinking without trying. A few months ago I quit the Rexulti, because my new insurance didn't cover much. I went spiralling down-hill fast! I said screw it, it's worth the money to feel normal. I'm back on it and I've never been happier. A slight weight gain in the beginning, but that went away and I lost the extra pounds."

10 / 10
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Ala · Taken for 1 to 6 months · December 1, 2016

Rexulti (brexpiprazole) "I was severely depressed for several months. My Dr. Tried everything that I could tolerate. I am on Trintellix & Klonopin. I started on the sample pack up to 1 mg. I snapped out of the hard depression within 10 days. I felt super. I talked Dr. in to an increase to 2 mg. I was irritable and nervous. I went back on 1 mg. and was back to my happy self. I would highly recommend Rexulti to anyone with hard to treat depression. This medication gets a full 10."

10 / 10
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Lisa · June 20, 2019

Rexulti (brexpiprazole) "Well I just started taking this Rexulti yesterday June 19, today is June the 20. Before starting this I was on the verge of committing suicide and since I had 2 pills rexulti I no longer want to die. It is a okay pill. I hope I don't gain weight I'm 290lb I'm trying to go on diet I will give another review in December 2019."

10 / 10
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Ajano · Taken for less than 1 month · May 27, 2020

Rexulti (brexpiprazole) "I'm only on day 5 of .5 mg and I feel a significant difference. I had overwhelmed myself with responsibilities and crashed and burned, then had bottomed out completely, when another major event happened. I do not want to be on antidepressants again, after 15 years of them and 2 1/2 yrs off, but they are working. My anxiety was out of control and I was seriously sick because of Corona virus isolation and my stress. I hope it continues to work at low dose. I hope I don't gain huge amounts of weight. I do have a prescription that will slightly counteract the weight gain."

10 / 10
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Grads... · Taken for 6 months to 1 year · June 13, 2019

Rexulti (brexpiprazole) "Update from my last post on July 5, 2018. Things are still going well but I have now gained 30 pounds within the past year of being on Rexulti. It has almost spiralled me back into a depression gaining so much weight, as body image was something that made me anxious and depressed already. Just wanted to give an update because I hadn’t seen anyone else mention the weight gain."

7 / 10
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semen... · Taken for 6 months to 1 year · February 29, 2020

Rexulti (brexpiprazole) "I really like Rexulti. I take 2mg in the morning and it really adds benefit to the already beneficial combination of Cymbalta 60mg 2 capsules once a day and Wellbutrin Xl 150mg 1 tablet once a day in the morning. I experience no side effects whatsoever."

9 / 10
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cleme... · November 7, 2016

Rexulti (brexpiprazole) "I've been on Rexulti for a month. It was added in addition to my Zoloft 150mg and Klonopin 1mg regimen after I told my psychiatrist that I felt like I was right on the brink of breaking out of my depression, but couldn't quite get there. I started with the sample pack, which consists of a week of .5mg tablets and a week of 1mg tablets. After about the 4th day, I started feeling better -- more energy, less anxiety. When I upped the dose to 1mg on the second week, I felt even better. At the end of the 2 weeks, I felt 100% myself. The only side effects I've experienced are slight insomnia (waking up in the middle of the night) and increased appetite. But I've got my life back, so it's worth it. I love this drug. It saved my life."

9 / 10
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Anony... · Taken for 1 to 6 months · February 27, 2019

Rexulti (brexpiprazole) "I started Rexulti as an add on three months ago. Since taking the medication I have had more energy to get things done. I have been able to sleep better at night. I have been diagnosed as treatment resistant and this has been the best medication I have tried. (After numerous med trials). My weight has remained unchanged, which is great. I have had no side effects from this medication and I take it before bed."

9 / 10
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Jewelz · Taken for 1 to 6 months · December 29, 2018

Rexulti (brexpiprazole) "Rexulti saved my life! I was diagnosed with MDD and my PCP tried all the regular antidepressants (buspar, effexor, wellbutrin). Those made me manic and worsened my depression. Dark cloud of gloom, not wanting to die, but not wanting to live like this. I found a Psychiatric NP who does medication management for people like me. She started me on 0.5 mg of Rexulti alone, no other meds and on day 4 my mo-jo came back. I am now in my 6 month of taking it in the a.m. and have a wonderful life again. Clear thoughts, happy, peaceful and content. Even though this medication is usually prescribed as an add on to a antidepressant this works beautifully for me alone. Ask your doc about it, you've got nothing to lose."

10 / 10
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Finally · March 11, 2016

Rexulti (brexpiprazole) "I have been on Rexulti .5mg now for over a month. I suffer from major depression and ptsd. I have tried over 30 different medications over the last 15 years and have either had no relief or terrible side effects. I also take 100mg of Zoloft. I no longer feel empty inside, I feel like I have some hope. I do have vivid dreams but I can handle that if it makes me feel so much better during the day. After many many years I may finally have gotten the right combo of meds. Good luck to all"

8 / 10
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Anonymous · November 9, 2015

Rexulti (brexpiprazole) "I have been taking Rexulti for about a week and a half. So far I have not experienced any negative side effects. I also take 450mg of Bupropion for my depression, which unfortunately has seemed to be less effective as time goes on and that's why my doc has been trying to find something I can add to the mix that will help me. I also take 50mg of Vyvanse, and 10mg of Dexedrine, for ADHD. I have tried Abilify and Latuda, and they did nothing for me - no side effects but no positive effects either, just... nothing. So far since I've started taking Rexulti I recently got the motivation to change my eating habits and try to lose some weight again. It's been over a year since I felt any kind of motivation to take better care of myself."

8 / 10
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Lafin · Taken for less than 1 month · January 21, 2016

Rexulti (brexpiprazole) "I have been on Rexulti for 3 weeks as an add on to Wellbutrin XL 300mg for major depression disorder. I have battled this for years trying so many different meds, finally found WB worked for me, however I still felt like I had mild depression. I wanted to smile again, laugh again and this med has done that for me. On my 4th day, I laughed and thought, this is working, finally! I was prescribed 0.5 for a week to increase to 1.0 the start of the 2nd week. The first week I felt hyper, energetic, and happy.. I had to call my Dr because I felt if I went up on the dose I would start having panic attacks and anxiety. She told me to stay on the 0.5 and increase if I felt like I needed to. I am still on the low dose. I'm in my 3rd week."

8 / 10
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lrivera · March 6, 2019

Rexulti (brexpiprazole) "I took rexulti for 5 months. I gained 20lbs even doing weight watchers. I stopped taking it because it was not working anyways. I hate antipsycotic drugs. I have struggled with my weight for years and they do nothing but add to the problem. I would rather learn to deal with my depression then take anymore drugs at this point in my life. I just wanna know how your suppose to feel good while gaining weight. I don't understand that concept at all. For people who need these types of medications that fine. But, after trying this drug and struggling with my weight I am totally finished with all antipsycotic medications but this is just me. I would not recommend this to anyone who has weight issues weather you feel good or not."

2 / 10
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Birdy · Taken for 1 to 6 months · June 6, 2019

Rexulti (brexpiprazole) "Rexulti is great as in treating my major depression, anxiety and PTSD. However, I am coming off it because I have been suffering from many side effects that I can't cope. I sleep 15-18 hours a day when I am on 1mg only and then I am 50% awake for the rest of the day, too sleepy to do anything. So here is a list of the side effects that I am experiencing: 1. Blurred vision 2. Hypertension 3. High cholesterol 4. Fatigue 5. Oversleeping No weight gain for me because I only get a chance to eat dinner due to oversleeping."

8 / 10
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Yeek · Taken for less than 1 month · December 4, 2015

Rexulti (brexpiprazole) "I have been on this medicine for two weeks now an have already notice a difference. I have been able to sleep all night, not cry as much. My outlook on life is starting to look better. I take this along with Wellbutrin. *****Please make this affordable for everyone*****"

8 / 10
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Sbano · April 24, 2019

Rexulti (brexpiprazole) "I was given Rexulti as an adjunct and it pulled me out of a dark hole pretty quickly (about 3 days). Dose of 1mg worked for about 6 months, relapse, went up to 2 mg then 3 mg— anxiety off the charts. Found the dosage of 1mg plus 0.5 mg (two prescriptions— cutting the higher dosages didn’t change the med on a molecular level) most effective. Great for a long time. It was also so much better than abilify (abilify gave me horrible nightmares). Fast forward to 1.5 years later— gained over 60 lbs (can’t lose anything either, even eating healthy foods— hunger unmanageable). So the weight gain is just as bad as Abilify. I am 2 weeks into tapering from 1.5 to 1 mg and have severe insomnia, body aches, joint pain, general sadness, lack of patience and interest in usual activities. Dr. won’t do a faster tapering. I want this med out of my body ASAP. I’m done. Great short term solution for depression, crappy for the long term. Get the manufacturer coupon."

7 / 10
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Lori · Taken for 2 to 5 years · August 9, 2019

Rexulti (brexpiprazole) "Began taking Rexulti May 2016 for MDD. At that time I weighed 160lb. This was a miracle drug for me. I had energy, obsessive thoughts and worries went away and a felt like a new person. Now, 3 years later I weigh 220lb and am miserable. I never changed my eating habits. Felt starved all the time. I'm stopping this medication. Now I'm at risk for Heart Attack, Stroke, Diabetes. So, yes Rexulti works but at a serious cost."

8 / 10
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Jojo · Taken for less than 1 month · September 10, 2016

Rexulti (brexpiprazole) "2 weeks in, my experience The good: Clear focus Appetite suppression Increased libido Calm demeanor Lower anxiety Able to get out of the house and interact with people The bad, but have subsided Dizzy Nauseous Insomnia, now i take it around 2pm vs before bed Drug is always unavailable when doc refills . Expensive without insurance Better than wellbutrin, Lexapro and abilify. So far so good"

10 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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