Brexpiprazole for Major Depressive Disorder User Reviews (Page 5)

• Hop...
• April 16, 2021

"After a sudden crisis of anxiety and paranoia, very schizophrenic-like, I was admitted through ER to a high-security psych ward. Was discharged two weeks later with several anti-psychotic meds that enabled me to go home, where I have amazing family support. Struggled for 5.5 years, trying a host of different meds, none of which helped much, and many made me feel worse. 6-7 months ago, I began Rexulti, and after the first 2 weeks on 1 mg, noticing improvement, we increased to 2 mg, and within 2 days, I got my mental and emotional game back. My family could not believe the difference. It was no placebo, as we had all but given up on meds being helpful. I have gained 10 lbs of belly fat, but the trade-off has been well worth it. I'm far from sure the benefits will last, but it's been wonderful to become functional and more at peace again, so I can continue to identify and address the deeper psychological factors underpinning my challenges here."

• LIF...
• Taken for 5 to 10 years
• July 4, 2022

"I give this medication a 1000/10. Rexulti has changed my life. I have MDD and panic disorder, and I’ve gone through bad insomnia spurts. I’ve been on it for about 5.5 years now, and I cannot explain how much it has changed my life around. I have done a lot of damage to my serotonin receptors, which has not allowed any medication that is serotonin-heavy to work. I’ve gone through trial and error with over 20 medications for my depression. My mood was never stable before Rexulti, my brain would go back and forth between super happy and sad every second. Rexulti has balanced my life entirely. I have tried going off of it to realize how much it helps me throughout my day. I’m very happy with the results!"

• MLC...
• Taken for 5 to 10 years
• August 7, 2024

"I've been on Rexulti for about 5 years. When I first started taking it with my antidepressant, I saw 70% improvement in depressive feelings, it was wonderful. And then I started gaining weight. While it does work, be prepared to gain weight (I gained at least 20 lbs). That being said, the pros of the medication were enough for me to stay on it, even with the weight gain. It works that good."

• Jan...
• Taken for 1 to 6 months
• July 14, 2022

"I was on this junk for 4.5 months and gained almost 60 lbs during that time. Before being on Rexulti, I never in my life experienced weight gain like that. It was like I was a balloon that just kept inflating bigger and bigger no matter what I did. I had to stop taking it once I hit 200 lbs because both me and my doc were afraid of how the rapid weight gain (with no signs of stopping) would affect my general health. I went on this due to major depression with suicidal ideation and self-harm, and the weight gain made all of that 100x worse. Now that it's been about 2 years off this stuff, when I try to remember my life from when I was on it, I can't. I only recall the weight gain because it was documented by my doctor and myself. I became completely withdrawn and didn't care about anything. During the time I was on this stuff, I quit my job, remained unemployed, stayed in bed all day, lost all my friends...and I didn't do anything about any of it because I was in a 24/7 haze. AVOID THIS MED."

• D2y...
• Taken for less than 1 month
• February 5, 2016

"Hesitating, began treatment tonight. I suffer PTSD, being able now, for the first time in decades, to come close to admitting how I have been living a marginal life at best. If you suffer trauma, war, hostage, abuse, neglect, torture, etc. and have been prescribed this medication, please send feedback. Thank you. I would be delighted to live some part of my life without reliving constant terror."

• Ang...
• Taken for 1 to 6 months
• July 16, 2019

"Was put on Rexulti to help with the Wellbutrin I’m on and Pristiq. I wasn’t happy to be prescribed this medication after looking at the side effects. My psychiatrist said that she will run a cholesterol panel to make sure that it’s not going up. Unfortunately, after I started taking this medication, I felt floating head (if that makes sense). I was almost falling asleep at the wheel driving around 4 p.m.-7 p.m. I should not be this tired. At this time at all. It’s never happened to me before. I stopped taking it, and I’ll be asking my doctor for a different prescription. I will be doing my research."

• gar...
• Taken for 1 to 6 months
• May 7, 2024

"I've been treatment-resistant for 12 years, ever since I had a motorcycle accident that resulted in a brain contusion. I was managing well before then. After 12 years of suffering, I was put on Rexulti. My depression is gone and I feel very motivated, which is all good. The downside is that I now have a temper that goes from 0 to 100 in a second. I'm very impatient with people and become very frustrated easily. My language has become worse than a sailor's, and my wife no longer believes that I love her. I don't want to go back to my old major depression, which would last for some time up to 2 years. I don't want to feel paralyzed again and sit around doing nothing all day. But I also don't want to hurt the people I love and sometimes wonder if I should just go back to being depressed. I'm so very confused. I find that I am fearful of certain things like going outside when it's dark or being alone for more than a few hours. I don't know what is worse."

• and...
• March 2, 2016

"I started the starter pack and my depression med a week ago, just upped my dosage to the 1 mg. I'm taking it in conjunction with 20 mg of Celexa. I've had MDD for about 10 years and nothing has worked. My mood is elevated and I don't have the bouts of crying right now, BUT I'm tired. It has me super nauseous. I have very weird dreams. It fights my insomnia, allowing me to sleep for at least 7 hours, but during the day I'm so lethargic I don't want to move. When I try to get up and move around, I'm super dizzy. I don't know if I will continue with this medication. I don't know how long this feeling will last or if it will last indefinitely while on the medication."

• Her...
• Taken for less than 1 month
• August 29, 2018

"I have had daily depression since 1983. I’ve literally tried over 30 meds over the years, maybe way more. Currently, I take 250 mg of Effexor, 60 mg of Adderall, 4 mg of Lorazepam, and Ambien. It has kept me alive, but I can barely earn a living for my family (I am the sole provider for a family of 6). My motivation and drive are nonexistent. I started Rexulti 3 days ago at 0.5 mg, and I already see a difference. It’s too early to really endorse the drug, but I wanted to share my early reaction. I’ll check in again if the website allows."

• Eff...
• Taken for less than 1 month
• February 10, 2019

"This medication helped a lot when I took it as a sample, but when my pharmacy called to tell me even with my insurance, the cost would be over $700.00 for a month’s supply, it obviously wasn’t an option for me anymore. Who can afford that?!?"

• Vic...
• Taken for less than 1 month
• January 3, 2020

"I had panic attacks and suicidal ideation, so I was prescribed Rexulti with my antidepressants. I had a panic attack flying, which never happened before, both to and from the location. I had a panic attack after a movie. I had a panic attack at night in bed. I have never had suicidal thoughts before, luckily, but there have been four clear incidences where I've had thoughts. I've been on it for four weeks."

• Har...
• April 27, 2017

"I have been on Rexulti for a little over 2 months. I started on 0.5 mg the first week and moved up to 1.0 mg the second week. I am taking it as an add-on to my Lexapro 40 mg for MDD. My depression was almost immediately better, but by the second week, my anxiety was HORRIBLE!! I began getting sores in my mouth from the constant movement of my tongue. It's uncontrollable, as is the eye blinking. I stay tired from my body being tense 24/7. My Dr. took my dosage down to 0.5 mg and increased my Ativan, but I'm still not doing any better. I'm fixing to stop it completely. I pray that the issues with my tongue and eyes will go away once I stop taking it."

• REX...
• August 19, 2016

"Yeah, I have bad MDD with anxiety and PTSD. At first, I was on 10 mg Lexapro with 0.5 mg Clonopin. I told my doc that I wasn't feeling any better. Now I'm on 20 mg Lexapro, 1 mg Rexulti, and 0.5 mg Clonopin. I'm noticing good changes. To balance the weight and restlessness, I decided to get up early and do a quick workout, and I substituted any junk food for apples, oranges, bananas, and raw carrots for protein - roasted chicken, cottage cheese, bagels... you can add what you like. I do have some vivid dreams, restlessness, headaches, blurry vision, and numbness/tingling in my right arm. The doc says it should go away."

• Ell...
• Taken for less than 1 month
• October 3, 2016

"I have been diagnosed over the years, in turn, as having (1) atypical anxiety; (2) PTSD; (3) bipolar 2; (4) MDD. I have been on many drugs over the years and most recently, Zoloft (stopped due to severe insomnia); Cymbalta (stopped due to sexual side effects); Latuda (stopped due to insomnia) and most recently, Rexulti. My mood and depression have greatly improved over the course of a week being on this drug, but the insomnia it engenders is very difficult. I wake every 2 hours and have to really work, with relaxation tapes, to get back to sleep, or I occasionally take 0.5 mg Klonopin. I have an extremely demanding work life and the lack of sleep is a big issue. If it resolves, I will say I'm very satisfied with this drug."

• Van...
• Taken for less than 1 month
• September 3, 2018

"The doctor said it would work fast if it’s going to work. I finally feel like my old self, before all the stress and trauma I had years ago, which I believe triggered my condition. Abilify worked before, but it’s too expensive. I never thought I’d have my concentration and memory and happiness back! But it’s here!"

• JR3...
• Taken for 1 to 6 months
• November 1, 2018

"I've seen a couple of other posts saying the same thing I have experienced. Rexulti worked wonderfully for 3 months, then it just stopped working, and I'm back to my old depression/anxiety self. I was so happy those 3 months, and I thought I was 'done'-problems solved! The doctor has increased the dosage, but I don't feel anything. Like some of you, I am very disappointed that my great summer free from anxiety and depression has ended."

• Nic...
• Taken for 6 months to 1 year
• March 2, 2019

"Extremely effective with no side effects other than one: I have gained thirty pounds! Really raises appetite, and weight seems harder to get off than if I wasn't on the drug. But this is the first winter I have not experienced depression since I hit puberty. I am 29. I highly recommend this drug."

• JMa...
• Taken for 2 to 5 years
• March 13, 2021

"I had taken Rexulti for about 2 years. Now, even a year after stopping, I have uncontrollable compulsive behaviors, tardive dyskinesia, and respiratory dyskinesia. While I was taking it, it seemed to help when my antidepressant wore off each afternoon. Then my wife started to notice weird facial movements, and some aspects of my normal life were going out of control. Breathing problems followed, and it’s been a downhill slide and battle ever since. This medication should not be allowed to be prescribed, in my opinion."

• dog...
• Taken for less than 1 month
• October 8, 2018

"I am 23 years old and have struggled with PTSD, BP, and MDD for more than half my life. This has caused problems off and on with impotence and libido, amongst other things. At 16, I was diagnosed with bipolar II by a psychiatrist. I never gave meds a chance because I thought 'only crazy people take meds.' This past year, I have stuck with 400 mg Lamictal, and it has balanced me for the most part. Not too long ago, I had a fight with my S/O and had a dangerous impulse decision. My psychiatrist now put me on Rexulti 2 weeks ago, and it has already changed my daily life. I have rediscovered my confidence, and my patient partner doesn't have to be so patient when it comes to the bedroom. I give this drug a 10/10. But what works for me might not work for you. But heed this... I feel better than I did before."

• Gus...
• Taken for less than 1 month
• January 4, 2023

"I was hopeless and suicidal. I said to myself that if this medication didn't work, I would end my life. Two days after taking it, I felt less hopeless, and after a full week, it saved my life. I am pretty smart, have an IQ of 143, and I have Asperger's. Rexulti saved my life; I can now do everything I want. I've started to see my friends again. Rexulti changed my life. I used to be a person who didn't even shower, but now I shower every day."

• Eri...
• April 20, 2023

"Awful medication. I’m coming off of it. I’m on day 3 of not taking it, and I don’t feel any different. It really wasn’t helping me anyway. I was still sad, emotional, and depressed, and felt like my life was out of control. I could cry at the drop of a hat. To add to everything, I have gained at least 10 lbs or more quickly, which certainly doesn’t help the situation. I feel like I gained all the weight in my face and stomach. It’s absolutely awful. I read one other review where she said she felt like a “big fat blob” and super bloated. That’s where I am. This medicine definitely increases my appetite and makes me crave sweets. If you don’t care about possibly gaining 10 to 20 lbs, I say go ahead and give it a go. Not worth it to me at all. I wish I had never started this awful medication."

• Spa...
• Taken for less than 1 month
• October 16, 2019

"I was delighted to get some samples of Rexulti from my Dr. because I was having akathisia. Well, after taking one dose, my vision became very blurry (it's taken over 24 hrs. to get to the point of being able to easily use my computer), I've felt 'stoned' for the past 24 hrs. and probably had a seizure. I have an underlying seizure disorder but only get them once every 4-6 months. So I read the drug insert and all the suggested side effects and don't want to take another dose. It did snuff out a period of akathisia, but I can barely remember the past 24 hrs. and don't feel anything at all (good or bad mood)."

• Mel...
• September 5, 2017

"This drug has been a major miracle drug for my 18-year-old son with autism spectrum disorder (ASD). He had been experiencing what I believe was a major depressive disorder for over 3 years. He stopped doing the things he once loved, he was angry, oppositional, anxious, OCD, and stopped eating-he went from 169 lbs to 108 lbs. I believe he wanted to die. We treated his autoimmune disorder with something called intravenous immunoglobulin (IVIG) and started on 0.5 mg of Rexulti about 4 months ago. Every one of his symptoms is almost completely gone. I attribute a lot of the improvements to this drug. He is doing all of the things he once loved and more. Simply amazing!!"

• MsC...
• Taken for 1 to 6 months
• June 22, 2018

"For two months, this drug was a miracle. I have coped for years with debilitating fibromyalgia and depression. Suddenly, I had my life back!! I was up early in the morning and active all day... something I haven’t been for 10 years. My thinking was no longer foggy, and I was motivated to accomplish all sorts of things. I enjoyed joining friends for activities and lived life fully. Then it just stopped working. I can even remember the time and place it happened. Truly sad - I had so hoped this would be “it” for me."

• Lis...
• Taken for 1 to 6 months
• July 3, 2024

"Rexulti 1 mg/day is working well for me as an adjunct to Zoloft and Wellbutrin. It has helped stabilize my depression and mood swings and seems to take the edge off when dealing with stressors. I was able to receive this medication at no cost after my daughter went to the Rexulti website and found coupons!"