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Vortioxetine Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Sep 5, 2023.

Applies to vortioxetine: oral tablet.


Oral route (Tablet)

Warning: Suicidal Thoughts and BehaviorsIncreased risk of suicidal thinking and behavior in pediatric and young adult patients taking antidepressants.Closely monitor for clinical worsening and emergence of suicidal thoughts and behaviors.Vortioxetine hydrobromide is not approved for use in pediatric patients.

Serious side effects of Vortioxetine

Along with its needed effects, vortioxetine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vortioxetine:

More common

Incidence not known

Other side effects of Vortioxetine

Some side effects of vortioxetine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Incidence not known

For Healthcare Professionals

Applies to vortioxetine: oral tablet.


The most commonly reported side effects included nausea, sexual dysfunction, headache, diarrhea, and dry mouth.[Ref]


Nausea usually occurred during the first week of treatment, with up to 20% of patients reporting nausea within 1 to 2 days of starting treatment. Nausea occurred more frequently in female patients, and in patients 65 years and older.[Ref]

Very common (10% or more): Nausea (up to 42%), constipation (up to 15%)

Common (1% to 10%): Abdominal discomfort, diarrhea, dry mouth, dyspepsia, flatulence, gastroenteritis, upper abdominal pain, vomiting

Uncommon (0.1% to 1%): Abdominal distention, epigastric discomfort, gastritis, salivary hypersecretion

Frequency not reported: Gastrointestinal bleeding

Postmarketing reports: Acute pancreatitis[Ref]


Very common (10% or more): Sexual dysfunction (up to 34%)

Uncommon (0.1% to 1%): Micturition urgency, nocturia

Frequency not reported: Sexual desire, performance, and satisfaction, vaginal bleeding[Ref]

Nervous system

Very common (10% or more): Headache (up to 14.7%)

Common (1% to 10%): Dizziness, sedation, somnolence

Uncommon (0.1% to 1%): Dysgeusia, formication, lethargy, myoclonus, tremor, vertigo

Frequency not reported: Serotonin syndrome

Postmarketing reports: Seizure


Common (1% to 10%): Abnormal dreams, insomnia

Uncommon (0.1% to 1%): Bruxism, derealization, initial insomnia, middle insomnia, restlessness, sleep disorder, tension

Frequency not reported: Anger/sudden outbursts of anger, dyssomnia, mood swings, poor quality sleep, terminal insomnia, withdrawal symptoms

Postmarketing reports: Aggression, agitation, hostility, irritation[Ref]


Common (1% to 10%): Accidental overdose, asthenia, fatigue

Uncommon (0.1% to 1%): Malaise[Ref]


Common (1% to 10%): Generalized pruritus/pruritus, hyperhidrosis

Uncommon (0.1% to 1%): Flushing, night sweats, rash

Frequency not reported: Contusion, ecchymosis

Postmarketing reports: Generalized rash, urticaria[Ref]


Common (1% to 10%): Arthralgia, back pain

Frequency not reported: Bone fractures, muscle tension[Ref]


Common (1% to 10%): Decreased appetite

Uncommon (0.1% to 1%): Increased low density lipoprotein/blood cholesterol/blood triglycerides, weight gain

Frequency not reported: Hyponatremia[Ref]


Common (1% to 10%): Nasopharyngitis

Frequency not reported: Epistaxis[Ref]


Common (1% to 10%): Influenza[Ref]


Uncommon (0.1% to 1%): Chest discomfort, hypotension, increased heart rate, prolonged electrocardiogram QT

Frequency not reported: Hemorrhage[Ref]


Uncommon (0.1% to 1%): Dry eye

Rare (0.01% to 0.1%): Mydriasis[Ref]


Frequency not reported: Anaphylactic reaction, angioedema

Postmarketing reports: Anaphylaxis, hypersensitivity reactions


Postmarketing reports: Hyperprolactinemia

Frequently asked questions


1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Cerner Multum, Inc. Australian Product Information.

3. Product Information. Trintellix (vortioxetine). Takeda Pharmaceuticals America. 2017.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.