Skip to main content

Vortioxetine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Vortioxetine Rexulti (brexpiprazole) Wellbutrin XL (bupropion)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Vortioxetine Rexulti (brexpiprazole) Wellbutrin XL (bupropion)
Prescription only

Vortioxetine may be used to treat depression in adults. It is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibits... View more

Prescription only

Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more

Prescription only

Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide.

More about Vortioxetine More about Rexulti (brexpiprazole) More about Wellbutrin XL (bupropion)
Ratings & Reviews

Vortioxetine has an average rating of 6.1 out of 10 from a total of 1566 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 31% reported a negative effect.

Rexulti has an average rating of 6.6 out of 10 from a total of 490 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 26% reported a negative effect.

Wellbutrin XL has an average rating of 7.5 out of 10 from a total of 492 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 16% reported a negative effect.

View all 1566 reviews

View all 490 reviews

View all 492 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Vortioxetine side effects

View all Rexulti side effects

View all Wellbutrin XL side effects
Drug Class
Generic Availability

N/A

Lower cost generic approved

Lower cost generic approved
Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.
Quantity 30 tablet
Strength 0.25 mg
Per unit* $54.27
Cost* $1,628.03

View all Rexulti prices

Quantity 30 tablet, extended release
Strength 150 mg/24 hours
Per unit* $78.44
Cost* $2,353.09

View all Wellbutrin XL prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Forms

N/A
  • Oral tablet
  • Oral tablet, extended release
Brand Names
Trintellix

N/A

 Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

66 hours

91 hours

30 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 354 drugs are known to interact with Vortioxetine:

  • 95 major drug interactions (440 brand and generic names)
  • 258 moderate drug interactions (1025 brand and generic names)
  • 1 minor drug interactions (3 brand and generic names)

A total of 600 drugs are known to interact with Rexulti:

  • 136 major drug interactions (610 brand and generic names)
  • 461 moderate drug interactions (1715 brand and generic names)
  • 3 minor drug interactions (9 brand and generic names)

A total of 559 drugs are known to interact with Wellbutrin XL:

  • 218 major drug interactions (951 brand and generic names)
  • 336 moderate drug interactions (1872 brand and generic names)
  • 5 minor drug interactions (16 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of vortioxetine such as dizziness, drowsiness... View more
  • Alcohol can increase the nervous system side effects of brexpiprazole such as dizziness... View more
  • Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more
Disease Interactions
First Approval Date

September 30, 2013

July 10, 2015

August 28, 2003
WADA Class View classifications

N/A

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Compare Drugs

To view a report comparing 3 (or more) medications, please sign in or create an account.

Create an account Sign In