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Vortioxetine: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 28, 2023.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Vortioxetine may be used to treat depression in adults. It is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibits serotonin reuptake, although how this contributes to its antidepressant effect is unknown. Nausea is the most commonly reported side effect and it may take up to 4 weeks before the full effects of treatment are seen. It is available under the brand (trade) name Trintellix.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with vortioxetine may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with vortioxetine. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with vortioxetine include:

Serious, sometimes fatal reactions may occur in vortioxetine is taken with an MAOI, such as isocarboxazid, phenelzine, or tranylcypromine. Do not take vortioxetine with an MAOI and within 14 days of stopping an MAOI. Do not start an MAOI within 21 days of stopping vortioxetine.

Reduce the dosage of vortioxetine when it is given with strong CYP2D6 inhibitors, such as bupropion, fluoxetine, paroxetine, or quinidine. Consider increasing the dosage of vortioxetine up to a maximum of 3 times the usual dosage when taking with a strong CYP2D6 inducer, such as rifampin, carbamazepine, or phenytoin.

Note that this list is not all-inclusive and includes only common medications that may interact with vortioxetine. You should refer to the prescribing information for vortioxetine for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use vortioxetine only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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