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Aripiprazole Dosage

Medically reviewed by Drugs.com. Last updated on Jul 10, 2023.

Applies to the following strengths: 5 mg; 10 mg; 15 mg; 20 mg; 30 mg; 2 mg; 1 mg/mL; 9.75 mg/1.3 mL; 300 mg; 400 mg; 720 mg/2.4 mL; 960 mg/3.2 mL; 441 mg/1.6 mL; 662 mg/2.4 mL; 882 mg/3.2 mL; 1064 mg/3.9 mL; 675 mg/2.4 mL

Usual Adult Dose for Schizophrenia

ORAL FORMULATIONS:
Aripiprazole Immediate-Release (IR):


PARENTERAL FORMULATIONS:
Aripiprazole Extended-Release IM Suspension:

Aripiprazole Lauroxil Extended-Release IM Suspension:

Re-initiation of treatment: 675 mg IM ONCE plus 30 mg of aripiprazole IR orally ONCE

Comments:

Use: Treatment of schizophrenia

Usual Adult Dose for Bipolar Disorder

ORAL FORMULATIONS:
Aripiprazole IR:
Monotherapy:


Adjunctive Therapy with Lithium or Valproate:

PARENTERAL FORMULATIONS:
Aripiprazole Extended-Release IM Suspension:

Comments:

Uses:

Usual Adult Dose for Agitated State

PARENTERAL FORMULATIONS:
Aripiprazole IR Injection:


Comments:

Use: Treatment of agitation associated with schizophrenia or bipolar mania

Usual Adult Dose for Depression

ORAL FORMULATIONS:
Aripiprazole IR:


Comments:

Use: Adjunctive treatment of major depressive disorder

Usual Pediatric Dose for Schizophrenia

ORAL FORMULATIONS:
Aripiprazole IR:
13 to 17 years:


Comments:

Use: Treatment of schizophrenia

Usual Pediatric Dose for Bipolar Disorder

ORAL FORMULATIONS:
Aripiprazole IR:
10 to 17 years:
Monotherapy OR Adjunctive Therapy with Lithium or Valproate:


Comments:

Use: Acute treatment of manic and mixed episodes associated with bipolar I disorder

Usual Pediatric Dose for Autism

ORAL FORMULATIONS:
Aripiprazole IR:
6 to 17 years:


Comments:

Use: Treatment of irritability associated with autistic disorder (including aggression, deliberate self-injurious behavior, temper tantrums, and quickly changing moods)

Usual Pediatric Dose for Tourette's Syndrome

ORAL FORMULATIONS:
Aripiprazole IR:
6 to 18 years:
Less than 50 kg:


50 kg or more:

Comments:

Use: Treatment of Tourette's disorder

Renal Dose Adjustments

Mild to severe renal dysfunction (glomerular filtration rate [GFR] 15 to 90 mL/min): No adjustment recommended.

Liver Dose Adjustments

Mild to severe liver dysfunction (Child-Pugh score 5 to 15): No adjustment recommended.

Dose Adjustments

ORAL FORMULATIONS:
Aripiprazole IR Formulation Substitutions:


CYP450 Dose Adjustments:

IMPORTANT NOTES:

PARENTERAL FORMULATIONS:

Aripiprazole Extended-Release IM Suspension:

MISSED DOSES:
Second or Third dose:

Fourth or Subsequent Doses:

CYP450 DOSE ADJUSTMENTS:
For patients receiving 400 mg IM once monthly:
For patients receiving 300 mg IM once monthly:

IMPORTANT NOTES:

Aripiprazole Lauroxil Extended-Release IM Suspension:
EARLY DOSING: This drug should not be given earlier than 14 days after the previous injection.
Dosing interval:

MISSED DOSES:
Monthly 441 mg dose:

Monthly 662 mg dose:

Monthly OR every 6 weeks 882 mg dose:

Every 2 months 1064 mg dose:

CYP450 DOSE ADJUSTMENTS:

IMPORTANT NOTES:

Switching from Other Antipsychotics:

Precautions

US BOXED WARNINGS:
INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS:


SUICIDAL THOUGHTS AND BEHAVIORS WITH ANTIDEPRESSANT DRUGS:
Recommendations:

CONTRAINDICATIONS:

Safety and efficacy of aripiprazole IR have not been established:

Safety and efficacy of extended-release IM aripiprazole have not been established in patients younger than 18 years.

Safety and efficacy of aripiprazole IR tablets with sensors have not been established in children.

Safety and efficacy of extended-release aripiprazole lauroxil have not been established in patients younger than 18 years and older than 65 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
Oral Formulations:


Immediate-Release IM formulation:

Extended-Release IM Injectable Suspensions: To be administered by a health care professional using the appropriate enclosed safety needles.

Aripiprazole Extended-Release Injectable Suspension:

Aripiprazole lauroxil Extended-Release IM Suspension:

Storage requirements:
Aripiprazole lauroxil Extended-Release IM Suspension: Store pre-filled syringes at 20C to 25C (68F to 77F), with excursions permitted between 15C and 30C (59F and 86F).

Reconstitution/preparation techniques: The manufacturer product information should be consulted.

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.