Raldesy Dosage
Generic name: TRAZODONE HYDROCHLORIDE 10mg in 1mL
Dosage form: oral solution
Drug class: Phenylpiperazine antidepressants
Medically reviewed by Drugs.com. Last updated on Apr 4, 2025.
2.1 Recommended Dosage
The initial dosage of RALDESY for the treatment of MDD in adults is 150 mg daily, taken orally, in divided doses. The dosage should be initiated at a low-dose and increased gradually, depending on clinical response and an tolerance. Occurrence of drowsiness may require the administration of a major portion of the daily dose at bedtime or a reduction of dosage
The dose may be increased by 50 mg daily every 3 to 4 days. The maximum recommended dosage for outpatients usually should not exceed 400 mg daily in divided doses. Inpatients (i.e., more severely depressed patients) may be given up to, but not in excess, of 600 mg daily in divided doses.
Administer RALDESY orally after a meal or light snack.
Screen for Bipolar Disorder Prior to Starting RALDESY
Prior to initiating treatment with RALDESY or another antidepressant, screen patients for a personal or family history of bipolar disorder, mania, or hypomania.
Switching to or from Monoamine Oxidase Inhibitor Antidepressant
At least 14 days must elapse between discontinuation of a monoamine oxidase inhibitor (MAOI) antidepressant and initiation of RALDESY. In addition, at least 14 days must elapse after stopping RALDESY before starting an MAOI antidepressant.
Dosage Recommendations for Concomitant Use with Strong CYP3A4 Inhibitors or Inducers
Coadministration with Strong CYP3A4 Inhibitors
Consider reducing RALDESY dose based on tolerability when RALDESY is coadministered with a strong CYP3A4 inhibitor.
Coadministration with Strong CYP3A4 Inducers
Consider increasing RALDESY dose based on therapeutic response when RALDESY is coadministered with a strong CYP3A4 inducer.
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