Mirtazapine for Major Depressive Disorder User Reviews

• Gru...
• Taken for 1 to 6 months
• March 20, 2021

Mirtazapine "I have been on Remeron for 5 weeks. Before taking this, I had extreme anxiety. I felt like I had a steel band tightening around my midriff, heart beating like it was going to explode, shaking when I had to go out, and lack of sleep. Now, on this, I have the confidence to go out, my heart rate feels normal, and thank goodness the steel band has disappeared. I hope this has been helpful to someone out there. Good luck."

• Dav...
• Taken for 1 to 6 months
• February 13, 2023

Mirtazapine "I've taken this medication for four weeks before leaving a review. I was previously on Sertraline for four years, which helped but caused regular headaches and made sleep problems worse. Mirtazapine helped with sleep immediately after I started taking it. The first few days, I could have slept all day but soon got into a regular sleep routine. After eight to nine days, I noticed that my mood had stabilized, and within the first two weeks, I was feeling much calmer. Extreme and erratic thinking had been subdued. This may have been, in part, due to improved sleep as well as the medication itself. After three weeks, I noticed a very real difference as my 'brain fog' disappeared. This was an almost overwhelming improvement. I am 50 years old and have suffered from depression/anxiety since childhood. My education and work life have been adversely affected by a lack of concentration and 'agitated' thinking. For the first time in my life, I am able to sit at my desk and work for hours at a time."

• Ano...
• September 10, 2019

Mirtazapine "30mg every night for PTSD, panic disorder, and major depression. Dealing with childhood trauma like physical and emotional abuse, sexual assault from a young age. Mind doesn't race as much, don't have dangerous thoughts anymore. I still experience panic attacks, occasional chest tightness if I think about it, but panic attacks have significantly gone down to at least maybe once a month if not every other month. I have gained a few pounds. If you have a sensitive stomach, eating right before or after taking this medication else you'll feel bad waves of nausea. My parents hid panic disorder as a child and lied to me about it, so I started experiencing them much more often in high school. Have I honestly never felt better mentally. I can't say enough good things about this medication! Wait it out if you really think this will work for you. I had tried over 6 medications, this one works miracles, and my mental health is 70-75% better."

• Pip...
• September 25, 2019

Mirtazapine "Okay, been on this drug Remeron for depression for the longest time! Have been on so many different drugs, worked for a while, then nada, side effects, etc. My history, for 20 more years, is major depression and anxiety disorder. Partial personality disorder, it’s kicking in now, sorry. Remeron has been a Godsend to me for a long time. I, along with others, would highly recommend this."

• rub...
• Taken for 6 months to 1 year
• September 7, 2020

Mirtazapine "Mirtazapine took my depression away in as little as 5 days. It was great, now I can live. 5 months later I started having severe bouts of breathlessness. My Psych says it is not the drug, it is anxiety. I stopped the drug for three days and the symptom totally went away. I went back on it real quick cuz the depression came on fast. Doc put me on 0.5 mg clonazepam twice a day, but doesn't help the breathing. Anybody else have this breathlessness?"

• MAR...
• Taken for 6 months to 1 year
• May 21, 2025

Mirtazapine "I took this medication for 6 months. It did not help with my depression, but my depression is very drug-resistant and ended up having ECT. The medicine made me sleep constantly at first. That got better. What did not get better was the 24 hours of being hungry. I gained 100 pounds and became diabetic. I should have been taken off the medicine when the doctor saw how much weight I was gaining. Instead, I had to beg him to take me off of it, and now I have to take diabetes medicine for the rest of my life. If you are going to try this medication, I would recommend stopping it if your appetite does not get under control."

• Ger...
• Taken for less than 1 month
• October 25, 2020

Mirtazapine "I'm on week 4 of mirtazapine 30mg and still feeling anxious. I have some really good days, so I think the tablet has started working, but then the next day I can be anxious all day long, which then disheartens me. I'm wondering whether to stick with it? Any experience would be welcome."

• Kil...
• Taken for less than 1 month
• March 27, 2020

"Before taking mirtazapine, I had been on sertraline for several months, with awful side effects. It turned me into an emotionless zombie. I didn't care about anything. They took me off when it triggered a hypomanic episode at 100mg. Mirtazapine compared to sertraline is night and day. This drug is wonderful. I started out at 7.5mg and had no initial side effects aside from grogginess after taking it (which went away after a few weeks) and dry mouth. Upped to 15mg after the first week. I sleep soundly (vivid sometimes crazy dreams but no nightmares) and wake up feeling energized. The 'dark cloud' of my depression started going away within the first couple of weeks. I have this newfound mental clarity... no more intrusive, negative thoughts and focusing on the horrible things of my past. I feel motivated and productive and joy in doing things again. I have not yet noticed any change in appetite or weight gain. Overall, mirtazapine has changed my life. I love living again!"

• Hun...
• Taken for 5 to 10 years
• July 16, 2019

Mirtazapine "I love Remeron! Even though it doesn't work sometimes, it definitely helps with mood, sleep, and your appetite when it does. I guess because I've taken it for so long, my body thinks it's a Skittle. But skipping a week or just taking it when needed has better results for me. Without it, I tend to lose weight every day from the effects of not eating when I'm busy. This helps me to keep my appetite and energy up until the next dosage. I hope this post and the medicine helps someone else as well. Just do not forget about the symptoms, be prepared for them, and enjoy your life on Remeron!"

• ste...
• Taken for 2 to 5 years
• July 20, 2014

Mirtazapine "I was on Remeron for about 2 years before. Helped very much with my depression. But although I often felt very sleepy near the beginning of the treatment, the massive fatigue eventually subsided to an acceptable level. 20 mins after taking it, I'm ready for bed. I can't keep my eyes open no matter what. I just restarted Remeron two days ago after more than a year being on it. As I type this, I feel fogged over, sort of sleepy, and immensely 'munchie'. As before when I took it, I'd find myself waking up several times a night going to raid the fridge and cabinets for munchie or sweet foods (and meats! definitely craved meat all the time). So again, on Remeron: eating again, sleeping some, more relaxed, less sad."

• Pre...
• Taken for 5 to 10 years
• March 24, 2023

Mirtazapine "I read about Remeron somewhere online and asked my doctor for it. I take 30 mg daily. It helps with depression and helps me sleep. Take it right before you go to sleep. If you take it earlier, you might get hungry. Because this medicine makes food indescribably delicious. Get this drug. It will help you immensely. Good luck!"

• jef...
• Taken for less than 1 month
• October 3, 2014

Mirtazapine "30 mg dosage. What to possibly expect based on my experience. Day 1: I was extremely tired. If I let my head hit the pillow, I would experience microsleep. I felt a little dizzy at times. Be careful around stairs if you suffer from vertigo. Functionality was delayed - my mind was in a cloud and it was difficult to work or concentrate on something that required deep attention. Day 2: I felt hungover. Hypersensitive to sounds, meaning that my mind would abnormally jolt to a greater sense of attention to a noise than before. The dizziness remained but at a decreased level. Day 3: Almost normal; just slightly tired."

• 81R...
• April 14, 2015

Mirtazapine "I started Remeron about 2 months ago for my severe depression and anxiety, and severe insomnia. The first night taking it, I slept the best I had in years! I didn't wake up feeling groggy, I actually felt better sleep-wise. I still felt very depressed, and that continued for a few weeks to the point I tried to commit suicide. Then I knew I needed help. They upped my Remeron to 45 mg at bedtime. I've been on 45 mg for a week, and I've noticed a big change. I feel normal again. I give Remeron a 10, it improved my life a great deal!"

• Kha...
• Taken for 6 months to 1 year
• June 10, 2019

Mirtazapine "I have MDD, anxiety disorder, panic attacks, and ASD (autism spectrum disorder). I was put on a combination of 7.5 mg Remeron and 100 mg of Pristiq. Within a few weeks, I stopped having panic attacks and I had no more depression. I am so grateful my doctor tried these drugs, it literally saved my life. Before, my life was hell, and I literally wanted to die. Now I am happy 99% of the time, and I can't remember the last time I cried. The only problem is I am constantly hungry, and I have gained 40 pounds in less than a year."

• xyz...
• September 16, 2014

Mirtazapine "I had been taking Restoril for sleep for several years. I found that my level of depression was worsening over time, and I had to take more and more to sleep. Finally, I decided that I needed to get off of Restoril. My doctor prescribed Remeron. I have been taking it for several weeks now and find that my mood has improved as well as my sleep. I am down to half of the Restoril I was taking before and hopefully may be able to discontinue it. The only downside of Remeron is that my appetite has increased, which is not good for me. Otherwise, I would have rated this as a 10."

• Sav...
• June 1, 2017

Mirtazapine "This drug saved my life. I never thought I'd say that, but due to a health issue, I have had chronic tension headaches that have now disappeared! Oh, and my depression and anxiety are gone on this. I'm able to feel blissful. I'm able to handle tough situations. I'm able to live. Give it time to work 'cause it could make your life so much better."

• Std...
• October 8, 2019

"Mirtazapine has been a godsend for insomnia. I’ve been on combinations of escitalopram and trazodone, sertraline and trazodone, then added Wellbutrin to the mix (to counteract the drowsiness/other side effects), and have been on mirtazapine 37.5 mg and a lowered dose of sertraline (was 150 mg, now 100 mg). I haven’t slept properly since I was 10 years old, and have only recently realized how important it has been to my mental and emotional health. If I’m having a horrible day full of anxiety attacks, mirtazapine can knock me out for 9-10 hours, and I wake up and can try again. It’s hell to keep experimenting with meds, but if you find a combo that gets your sleep right and crazy panic attacks down, work out every day (try martial arts/mma), cut toxic people out of your life, surround yourself with family and genuine friends, and go to therapy even if you find yourself saying the same thing every time. The meds aren’t your only solution. You can do this. Keep fighting."

• Nic...
• Taken for less than 1 month
• April 10, 2020

Mirtazapine "I've been dealing with a lot of family issues plus I suffer from MDD and GAD. Anyway, I believe I also have PTSD and I was stuck on repeat in my mind and could not stop reliving a past 'argument' I had with my family. I took 15 mg last night, and already the obsessive thoughts have diminished. I also have subconscious fears of being poisoned. Those have also diminished since yesterday. Hope it continues, I just worry about weight gain, but if my mind isn't occupied with all the rubbish, I can focus on exercise."

• Tru...
• Taken for 2 to 5 years
• February 26, 2018

Mirtazapine "Literally a lifesaver. I have been on every antidepressant known to man, and I thought they were all a joke. They never worked. I ended up in a behavioral health facility for 2 weeks because of a major depressive episode and constant thoughts of suicide. They gave me this medication, and I stuck with it. Initially, it will make you sleepy and crave food like crazy. You will also have crazy dreams. This will pass in time. I haven’t fallen into a depression in over 3 years now, which is a record. I have recently lost my job because of a different medical condition. I am on food stamps and might have to sell my home, but amazingly it's no big deal to me. Remeron and other forms of therapy have changed my whole outlook on life. If anyone has tried every medication and it hasn’t worked, give this one a try. The only downside at this point I can think of is sometimes when you want to feel down or depressed (I know it sounds weird), you are not able to."

• Kay...
• Taken for 6 months to 1 year
• July 7, 2018

Mirtazapine "I love love love Remeron. I have been severely depressed for more than a decade. I was on bupropion before, but then had a seizure on it and could no longer continue. I had not taken any helpful medication for years after that. I told my doctor my problems and with the things that I was looking to have alleviated, he recommended Remeron. I have had extreme appetite suppression for a long time as well due to my depression, and I needed a medication to increase my appetite. I was having trouble sleeping due to overthinking at night. I had a lot of ideation. Remeron helped me with all of these symptoms. It helps me eat like a normal person would. It is quite sedative, so it helps with sleep, which is super important for depression, to get enough. And it helped overall with mood. A good one!"

• Cou...
• Taken for 1 to 6 months
• August 23, 2023

"I was prescribed mirtazapine for major depressive disorder, sleep, and ARFID. When I started on 15 mg, I didn't really notice any major side effects other than being a little tired when I woke up if I took the med too late at night. It also doesn't knock me out when I take it. I can still do what I need to do, but when I lay down to go to sleep I go right to sleep and I sleep hard. I've noticed a huge difference in my anxiety and depression. I still have bad days, and I haven't noticed any change in my appetite, and I just upped my dose last night from 15 to 30. Still no side effects. If you're anything like me, don't scare yourself reading horror stories. Like a lot of people have said before, everyone is different when it comes to medication. I also feel like a lot of people read into too much, and some of their symptoms are the anxiety of taking the medicine itself (I do the same thing). If you're reading this, just try it. If it doesn't work, you can always try something else."

• Joh...
• Taken for less than 1 month
• April 24, 2025

"Age 40. Gender: Male. Diag: Depression, anxiety, anger, irritability, OCD. Dose: 30 mg. Pros: -Higher libido (I always had good libido, but now it's at a puberty level. 'Getting there' only takes about 20 seconds now with my beautiful girlfriend, soon to be wife). -Erections are super firm. I used to need Viagra or Cialis to stay firm. -Better social skills and talking to strangers (Finally. Never could before). -Repetitive noises that used to bother me no longer bother me. -Less irritable, less angry, more happy. Better chemistry with my girlfriend, with no arguments (as we used to argue a lot). Cons: -Food cravings (Often times double portions. But it doesn't bother my weight as I exercise regularly.)"

• 123...
• Taken for 1 to 6 months
• May 24, 2020

Mirtazapine "I gained 25 lbs in 6 weeks on Remeron. I was 125 lbs when I started the medication and now I’m bordering on overweight. Luckily, when I stopped the medication, the weight gain stopped. It helped slightly with my chronic migraines and did not make me sleepy. I feel it did improve my quality of sleep somewhat, but not enough to continue gaining weight at that rate. I did exercise and watch what I ate, but it just made me too hungry. It had no effect on my depression, unfortunately, and I feel much worse about myself after gaining all that weight. Ketamine therapy has been the only antidepressant to work for me yet."

• Amb...
• Taken for 1 to 2 years
• October 5, 2020

"I've been on mirtazapine for just over a year now, and it has done wonders for my mental health. I have struggled with anxiety and depression since my early teens, and this has worked wonders. I definitely noticed an increase in my appetite, so I have gained a bit of weight, but it's worth the mental stability. I'm on 30 mg a day, I started on 15 mg, but this wasn't a high enough dose. The only thing I'd note is that going off this cold turkey is a terrible idea. I missed a week because of a mistake on my doctor's behalf, and the withdrawals were terrible. I had the sweats, couldn't sleep, barely ate, and my depressed and anxious thoughts came back really strongly. Luckily, after three days of being back on it, I'm starting to feel better. Overall, I'm so happy this medication has worked for me and brought back a quality of life I'd been missing for years."

• Ano...
• Taken for 1 to 6 months
• December 29, 2015

Mirtazapine "Having failed most SSRIs, Remeron was a real surprise. It calmed me, helped me sleep, helped me focus, but most importantly had almost no side effects. My appetite went crazy the first week but mellowed out afterwards. I get pretty drowsy about an hour after taking it, so I only take it at bedtime. I had to drop from 45 mg to 30 mg due to it amping me up rather than sedating. Works fine, no tolerance type effects unlike Z-drugs."