Mirtazapine for Major Depressive Disorder User Reviews (Page 4)

• Bubzz...
• Taken for 1 to 6 months
• April 26, 2016

"I'm about 4 weeks in on 15mg slowly transitioning to 30mg. I'm a 6'2 male in my mid 30's and before i began Mirtz i was 182 pounds. Today i'm 199 pounds in just 4 weeks! One other condition this drug is used for is an appetite stimulant and i can see why as i will eat anything anyone puts in front of me. I feel like an ogre now when i eat, literally can eat 2 full meals at a time. Trying to exercise more to fight off the crazy gains. Overall i'm taking this for Major depression, anxiety and insomnia. So far so good for those 3, things are slowly getting better. The dreams from Mirtz are crazy! Every night is a new adventure. Don't feel too groggy the next day. I will post an update in a few weeks once the 30mg has a chance to kick in."

• Kel
• Taken for less than 1 month
• November 12, 2019

"So I’ve only been on this medication for a little over a week. I’m currently taking Prozac in the morning and mirtazapine at night. I was recently put on mirtazipine because my depression tends to stop my appetite and I’ve lost a ton of weight. My doctor added mirtazipine to my regimen to help me gain weight and also help with my OCD and anxiety. When I tell you I want to eat things I don’t even like.... I have cravings for seafood and I’ve never liked seafood. I’ve also felt a lot more relaxed and it helps me sleep so well. So far I feel like my spirits are up and I’m on the road to gaining weight which is a must for me."

• NAE
• August 10, 2015

"I have taken almost everything for depression and Remeron has helped the most. The first dose of 15mg knocked me out from 10pm to 4pm the next day. After 2 weeks, my depression was GONE. I have to take Celexa with it or I feel extremely anxious. Taken together, I feel...dare I say it...normal. The only negative is weight gain. I've always been skinny and unable to gain weight and have never gained weight on any other med. I've gained about 20 lbs on Remeron without even eating more and have been unable to lose weight on a low carb diet. Low carb seems to help me not gain more weight. Start a low carb diet as soon as you start Remeron to minimize weight gain!"

• Rov
• December 16, 2015

"Two great benefits are one, not being depressed or very little, and two, sleeping very well. The bad side effects are unfortunately also very extreme, eating voraciously at night, getting up in your sleep and hitting the fridge, and the other is inability to be awake and be efficient at work in the early morning hours. The later has been particularly detrimental to my career. Everybody is different, yes, but I've seen many people posting some or all of my symptoms in various webpages. My wife and son are very concerned now for almost 10 years and nobody suggesting better alternatives. While the benefits are still there, the over eating and tiredness have gotten worse every year. I feel trapped. It's either go insane or be fat and jobless."

• Hollz
• Taken for less than 1 month
• March 5, 2016

Remeron (mirtazapine) "So far, I'm very happy as my nausea, vomiting, stomach cramps and anxiety have subsided. Not much relief from depression yet on day 5, but understand it takes time. It does make my tongue numb for a bit after I take it and I've had vivid dreams every night on it."

• MDD
• Taken for 10 years or more
• October 27, 2019

"I have been taking Mirtazapine for 11 years for MDD, now at 45 mgs. As a person who cannot tolerate SSRI or SNRI antidepressant medications, this has been what keeps me functional. While it doesn't anymore, it also worked beautifully to treat my sleep disorder and extreme insomnia for the first few years. The only side effect that I personally deal with is nighttime binge eating and the resulting weight gain. Whatever. I'd rather be slightly overweight and able to function and be part of life."

• Seaso...
• Taken for 1 to 6 months
• May 25, 2018

Remeron (mirtazapine) "I took this because I was severely suicidal and depressed due to seasonal MDD. I started it because my mother was worried and I though If I went on medication it would let her relax a little. It helped me sleep and completely erased my suicidal thoughts and urges. I got a restful full night’s sleep every night. At the start the downsides were an inability to focus, feeling extremely tired during the day and having my suicidal thoughts and urges increase drastically. These only lasted like a few days then everything was okay again. The only side effect that didn’t go away was weight gain, but I’d rather be heavier and alive than skinny and dead. I only went off of it because my depression is seasonal so I don’t need it at this time of year, but I will definitely start again in the fall."

• Anonymous
• Taken for less than 1 month
• October 29, 2021

Remeron (mirtazapine) "Hi all just wanted to give an update on remeron 15 mg taken nightly. I'm diabetic type 2 and spoke to a few doctors regarding it's safety efficacy with diabetes, although most SSRI"S somehow interfere with diabetes I took the plunge and decided to still try it again cos it worked so well, could not have made a better decision, I sleep much better though using 75mg serequel and stilnox mr as well I've had a bit of brain fog in the morning but subsides at about 10 in the morning and then I'm great to go"

• Anonymous
• Taken for 6 months to 1 year
• January 17, 2020

"Amazing drug, really helped with my depression and insomnia. Takes a good 4 to 6 weeks to fully kick in and start working. The first two weeks I had terrible headaches and stomach pains but they lifted eventually. The only major side effect I've suffered from it is that I've put on 3 stone in six months while taking this medication. Even though it's the best drug I've ever taking for my major depressive disorder, I'm going to have to come off it as I can't afford to put on any more weight."

• kate
• Taken for 1 to 6 months
• April 17, 2019

"I have been on Mirtzapine for approximately 4 weeks, in those 4 weeks I have been able to sleep through the night for the first time in months, I've been able to eat healthy amounts, I've gained 7 pounds which makes me no longer underweight, and have just had generally more upwards moods. Although Mirt hasn't worked for my anxiety, after about 7+ medications mirtazapine is the first one to significantly help me sleep through the night and be able to get up in the morning and have a routine. I can't believe how this antidepressant makes me feel. If you are afraid of the weight gain, try it anyways. The ONLY negative things that have to do with this drug for me are that I get sweaty at night and have had a few nightmares, however they are very tolerable as i've never been actually scared of my nightmares. PLEASE try this medication, it may change your life as i've barely been on it a month and it's changed mine."

• hospi...
• July 15, 2021

"I am 30 year old female with no chronic health conditions. I started taking Remeron when I was hospitalized in May of 2021. due to increased frequency of panic attacks, suicidal ideation, and no appetite, I could no longer work. Tried several medications since 2010 - sertraline, paroxetine, duloxetine, citalopram, combined w lorazepam, diazepam, or clonazepam - bad side effects, depressive symptoms returned. I eventually tried lamotrigine which gave me a rash & swelling of lymph nodes. I tried lurasidone which seemed to help but too expensive to continue w/o health insurance. After 5 days in the hospital and taking Remeron, I felt stabilized in a way I didn't think was possible. I am now able to cope with day-to-day stressors, sleep well, energy to do things I used to avoid, haven't gained weight, no issues with sex drive at all. I have had none of the terrible side effects I had w/ SSRI's/anti-psychotics/benzodiazepines. This drug truly changed my life, I feel like a different person."

• notre...
• March 23, 2019

"I was given this med to deal with depression, insomnia and anxiety. The first night I took 7.5 mg and yes, I slept, and slept, too much. Was told to bump up to 15 mg, and the first day and night I felt good. Now a month later, I am more depressed than ever before, shaking, feel like I have the flu, and can't sleep more than 2 hours. Worst part is the horrendous heart palpitations, my heart literally skips beats now. I won't even talk about the 7 pounds of weight gain in a month. I wish it had worked as it seems to help some people."

• Aaron
• March 20, 2015

"Hello peeps what can I say ive suffered from major depression all my life well since was 18 I had been on numerous medications nothin seemed to work then my doctor said try these mirtazapine the low levels didnt work im on 45mg and have been for 9 years they help u sleep give u a great appetite at night basically they stop u from thinkin ur goin of ur rocker I still get highs an lows through out the day I still think im bipolar with the moodswings example jekel/hide.They really do help in so many ways but the withdrawals can be bad I get severe stomach cramps feel nauseous.also feels like ur loosing ur mind and ur anxiety levels can go up"

• Renay...
• Taken for 1 to 6 months
• May 15, 2020

Remeron (mirtazapine) "I started on this drug Remeron at 15 mg found that it worked for two weeks then the anxiety came back so I upped it to 30 and guess what same thing happened so I’m trying 37.5 I hope these meds begin to work and stay that way"

• shahana...
• Taken for 1 to 6 months
• March 30, 2015

"My life was about to end few years back due to OCD, i wished to die a couple of times, i had lost all hopes of recovery but this medicine came in my life as a miracle , i took it for 5 months and have now get rid of it . i have stopped taking it more than a year ago , and i am a completely healthy person now and enjoying a wonderful life . it does not have any special side effects except weight gain or dizziness"

• Ello...
• Taken for less than 1 month
• January 21, 2016

"Have been prescribed 15mg Mirtazapine with Lamotrigine for severe Bipolar depression/Unipolar disorder GAD. Just to say if you're taking this medication with another as I am, unwanted side effects may be greater. Restlessness in legs and arms, cold sweats, vivid nightmares/night terrors, no appetite, no mental stimulation/dullness. These unwanted side effects should weaken over time since this medication is still pretty new in my system. I wish LOTS of luck to those who are really trying to treat their depression (if you've mentally been to Hell and back). You're not alone, look at all these reviews!"

• Jay
• Taken for 6 months to 1 year
• October 23, 2021

"I've been on a bunch of antidepressants - sertraline, fluoxetine, fluoxetine + mirtazapine, venlafaxine + mirtazapine - but about 5 months ago I changed to just mirtazapine and increased the dose to 45mg and it has been amazing! I didn't really believe that any antidepressants would actually work until I went on mirtazapine. I've been hospitalised about a dozen times for psych reasons in the last two years + a couple of suicide attempts but I haven't even been to the emergency department since I've been on mirtazapine 45mg. I hear a lot of people talking about weight gain on it but I've actually lost a fair bit of weight on it because I actually want to get out of bed and go do things. I'd previously been on quetiapine and that made me hungry & caused weight gain but I haven't had that at all on mirtazapine. Love it so much, don't plan to ever stop taking it."

• Redfi...
• Taken for 1 to 6 months
• May 28, 2021

"Twelve weeks in with using Mirtazapine for Clinical Depression, or MDD. My disorder started in January 2020. I am now taking 15mg at night and sleep 8/9 hours. I had a couple of vivid dreams in the beginning but, no longer. I wake up energized. I run high energy so my anxiety is still present but not as severe. I’m able to supplement .25mg/day of Clonazapam, taken PRN. Hoping I will need this less and less given more time. Also, I’m trying to regain some weight, but it seems I’ve levelled for now. I eat a healthy whole food plant based diet so calories are low. Also, I eat smaller portions than I used to. I will have to remain on Mirtazapine indefinitely and I’m good with that if it continues to help me have better days and nights."

• Deus...
• May 10, 2020

"I've been on Mirtazapine 45mg about 30 years. For the first 20 years, every thing went as expected, in that it mitagated my MDD and I consistently slept through the night. Then, about 10 years ago, I got my first bottle of "blanks", pills that I feel do not contain the drug, or only a minute amount. Such bottles started coming my way with increasing frequency, until it reached the point where I switched to the name brand Remeron, even though I would be forced to use the soltabs and they would cost slightly more than $5 a pill. You don't sleep, at least not so it does you much good, The last box were a mix of inert and at most 10% of the drug specified. I could tell by the taste of the first sol tab. Mirtazipine is QUITE bitter. This was as sweet as the sol tab sample the company reps hand out to doctors so they'll be able to tell patients that its all right. I am on the third week of withdrawal and have been only able to snatch a couple of hours a night."

• JS81
• Taken for less than 1 month
• July 19, 2019

"I was prescribed Mirtazapine by my VA Physician and took it yesterday evening for the first time. I slept for about 12 hours and woke up feeling awful. I felt lethargic and not myself. I was very irritable and felt like I was oocupying someone else's body. I know it sounds strange, but that's the best I can describe it. The worst part was waking up at 1 am after a terrifying dream that demons were attacking me. I seldom I have dreams like that, but it scared the poop out of me. I also heard my phone alert me that I had an email from a co-worker, but when I woke back up there was no email whatsoever. Am I losing my mind?"

• Jimbo
• Taken for 1 to 6 months
• April 1, 2021

"After more than 30 years of major depression and severe anxiety, I finally stumbled upon Remeron during my last stay in the psych ward, and it has been a game changer. I had been taking 200 mg amitriptyline per day and now am on 30-45 mg mirtazapine. (I'm a big guy and unfortunately getting bigger.) I'm also (previously) a long-term, professional alcoholic and have not touched a drop or even thought about it since my first dose of Remeron some months ago. I'm convinced that this medication has saved my life and would encourage anyone at the end of his or her rope to try it. Better yet, don't wait until crunch time and instead consider it as a second-line treatment if SSRIs or SNRIs don't work for you."

• Not
• Taken for 6 months to 1 year
• December 2, 2020

Remeron (mirtazapine) "I took Remeron for 6 months, it did wonders for my depression and anxiety during the first weeks, I started with the 15mg dose, but as time passed, the effect started to disappear, I increased my dose to 30, the same thing happened, the effect disappeared, now I am taking 45mg, and the effect is not at all the same as I felt in the first weeks, unfortunately this medicine is not a long-term medicine, I am thinking of changing"

• Emmy3...
• June 3, 2016

"Seemed to help the depression but the tiredness left me unable to function. I was on this for a year and was unemployed for most of it, this meant it didn't matter than I found it impossible to wake up before lunch time. No matter how early I took the pill (6pm) I would be sound asleep 20 minutes later and could easily sleep 15-16 hours on these. I recently got a job and could not wake up enough to function at work. I had to stop taking them and now I can easily wake at 7am and last the entire day at work. I would consider these more of a sedative than an antidepressant."

• fattyb
• October 18, 2016

"9 months ago I was prescribed this in combination with venlafaxine to treat major depressive disorder, anxiety and complex ptsd. Initially I did not notice any side effects but about 3 months in I suddenly gained so much weight that none of my clothes fit. It seemed to almost happen overnight and whilst I was struggling with the fact that I had NOTHING to wear, I started to get hot flushes, pee my pants without realising and sweat like a sauna at random moments, esp in my groin area. Lovely. Add to that - memory loss, freaky (exhausting) dreams, fingernails that split if you look at them and trembling hands .....what do you get? A fat sweaty smelly trembly LUMP who is now too depressed and anxious to even go out the front door. I quit."

• M J
• Taken for 1 to 6 months
• October 25, 2020

"This is the first review I have submitted. I’m doing so to save someone from the bad experience I had from this drug, mirtazapine. Was prescribed this to help with anxiety, depression and sleep. The first night I slept quite well, but things became steadily worse after that. It gave me a sort of sleep paralysis where I would wake up but not able to move my body. Also have me tremors, restless legs and pains in my joints. The doctor suggested to increase the dose, which made things worse still. So after 6 weeks of hell, I came off it and switched medications. It took another few months for the withdrawal effects to stop (muscle twitches etc...). It may be perfect for some, but this was not a good match for me."