Generic Name: levomilnacipran (LEE voe mil NA si pran)
Brand Name: Fetzima
What is levomilnacipran?
Levomilnacipran is used to treat major depressive disorder.
Levomilnacipran may also be used for purposes not listed in this medication guide.
You should not use levomilnacipran if you have untreated or uncontrolled narrow-angle glaucoma.
Do not use levomilnacipran within 7 days before or 14 days after you have taken an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
Levomilnacipran is not approved for use by anyone younger than 18 years old.
Before taking this medicine
Do not use levomilnacipran within 7 days before or 14 days after you have taken an MAO inhibitor. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.
You should not use levomilnacipran if you are allergic to levomilnacipran or milnacipran (Savella), or if you have untreated or uncontrolled narrow-angle glaucoma.
To make sure levomilnacipran is safe for you, tell your doctor if you have ever had:
heart disease, high blood pressure, heart rhythm disorder;
a bleeding or blood clotting disorder such as hemophilia;
bipolar disorder (manic depression);
low levels of sodium in your blood;
bladder obstruction or other urination problems;
if you drink large amounts of alcohol; or
if you take a diuretic ("water pill") or use migraine headache medicine.
Some medicines can interact with levomilnacipran and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
It is not known whether levomilnacipran will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
It is not known whether levomilnacipran passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Do not give this medicine to anyone younger than 18 years old without the advice of a doctor. Levomilnacipran is not approved for use in children.
How should I take levomilnacipran?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
You may take levomilnacipran with or without food.
Do not crush, chew, break, or open a levomilnacipran capsule. Swallow it whole.
Your blood pressure and heart rate will need to be checked often.
Do not stop using levomilnacipran suddenly, or you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking levomilnacipran?
Avoid drinking alcohol. It may raise your blood levels of levomilnacipran.
Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with levomilnacipran may cause you to bruise or bleed easily.
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Levomilnacipran side effects
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
painful or difficult urination;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
pounding heartbeats or fluttering in your chest; or
low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, muscle cramps, loss of coordination, feeling unsteady, fainting, shallow breathing.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Older adults may be more sensitive to the side effects of this medication.
Common side effects may include:
nausea, vomiting, constipation;
fast heart rate; or
decreased sex drive, impotence, or difficulty having an orgasm.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Levomilnacipran dosing information
Usual Adult Dose for Depression:
Initial dose: 20 mg orally once a day for 2 days, then increase to 40 mg orally once a day
Maintenance dose: 40 to 120 mg orally once a day
Maximum dose: 120 mg/day
-The dose may be increased in increments of 40 mg at intervals of 2 or more days based on tolerability and efficacy.
-Efficacy was established in trials lasting 5 weeks.
Use: Treatment of Major Depressive Disorder (MDD)
What other drugs will affect levomilnacipran?
Taking levomilnacipran with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic medication, muscle relaxer, or medicine for anxiety, depression, or seizures.
Tell your doctor about all your current medicines and any you start or stop using, especially:
any other antidepressant;
tryptophan (sometimes called L-tryptophan);
a diuretic or "water pill";
This list is not complete. Other drugs may interact with levomilnacipran, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 2.01.
More about levomilnacipran
- Levomilnacipran Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 158 Reviews
- Drug class: serotonin-norepinephrine reuptake inhibitors
Other brands: Fetzima