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Levomilnacipran Side Effects

In Summary

Commonly reported side effects of levomilnacipran include: erectile dysfunction, nausea, and orthostatic hypotension. Other side effects include: constipation, ejaculatory disorder, epididymitis, increased heart rate, palpitations, premature ejaculation, sinus tachycardia, tachycardia, testicular pain, urinary hesitancy, vomiting, delayed ejaculation, ejaculation failure, and hyperhidrosis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to levomilnacipran: oral capsule extended release

Along with its needed effects, levomilnacipran may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking levomilnacipran:

More common
  • Difficult urination
  • fast, pounding, or irregular heartbeat or pulse
Less common
  • Anxiety
  • arm, back, or jaw pain
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • chest tightness or heaviness
  • cloudy urine
  • confusion
  • decrease in the frequency of urination
  • difficulty in passing urine (dribbling)
  • difficulty with speaking
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drooling
  • dry mouth
  • fainting
  • headache
  • irritability
  • loss of balance control
  • muscle trembling, jerking, or stiffness
  • nausea
  • painful urination
  • pounding in the ears
  • rapid or irregular heartbeat
  • restlessness
  • shaking
  • shortness of breath
  • shuffling walk
  • slow heartbeat
  • stiffness of the limbs
  • sweating
  • trouble sleeping
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
  • unusual tiredness or weakness

Some side effects of levomilnacipran may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Difficulty having a bowel movement (stool)
  • increased sweating
  • loss in sexual ability, desire, drive, or performance
  • vomiting
Less common
  • Abdominal or stomach pain
  • bloated or full feeling
  • decreased appetite
  • dry eyes
  • dry skin
  • feeling of warmth
  • headache, severe and throbbing
  • hives or welts, itching, or rash
  • passing gas
  • red eye
  • red face, neck, arms, and occasionally, upper chest
  • sudden sweating
  • thirst
  • yawning

For Healthcare Professionals

Applies to levomilnacipran: oral capsule extended release

General

The most commonly reported side effects were nausea, erectile dysfunction, constipation, and hyperhidrosis.[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 17%)
Common (1% to 10%): Constipation, vomiting
Frequency not reported: Abdominal pain, flatulence[Ref]

Genitourinary

Common (1% to 10%): Erectile dysfunction, ejaculation disorder, testicular pain, urinary hesitation
Frequency not reported: Delayed ejaculation, ejaculation failure, epididymitis, hematuria, organic erectile dysfunction, pollakiuria, premature ejaculation, proteinuria, psychogenic erectile dysfunction, seminal vesiculitis, testicular pain, urinary retention[Ref]

Cardiovascular

Common (1% to 10%): Hot flush, hypertension, hypotension, increased blood pressure, increased heart rate, palpitations, tachycardia
Frequency not reported: Angina pectoris, chest pain, increased orthostatic blood pressure, increased orthostatic heart rate response, increased systolic/diastolic blood pressure, labile hypertension, orthostatic hypotension, postural orthostatic tachycardia syndrome, sinus tachycardia, supraventricular and ventricular extra systoles[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis, rash
Frequency not reported: Dry skin, erythematous rash, generalized rash, macular rash, maculopapular rash, pruritus, urticaria[Ref]

Metabolic

Common (1% to 10%): Decreased appetite
Frequency not reported: Hyponatremia, increased blood cholesterol, thirst[Ref]

Psychiatric

Frequency not reported: Activation of mania/hypomania, aggression, agitation, anger, bruxism, discontinuation syndrome, panic attack, suicidal thought and behaviors in adolescents and young adults, tension[Ref]

Nervous system

Frequency not reported: Extrapyramidal disorder, migraine, paresthesia, postural dizziness, seizure, serotonin syndrome, syncope[Ref]

Ocular

Frequency not reported: Angle closure glaucoma, blurred vision, conjunctival hemorrhage, dry eye[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity[Ref]

Hematologic

Frequency not reported: Abnormal bleeding[Ref]

Hepatic

Frequency not reported: Abnormal liver function test[Ref]

Respiratory

Frequency not reported: Yawning[Ref]

References

1. "Product Information. Fetzima (levomilnacipran)." Forest Pharmaceuticals, St. Louis, MO.

Some side effects of levomilnacipran may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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