Olanzapine for Major Depressive Disorder User Reviews

• Doc
• May 17, 2020

"This olanzapine is the worst drug ever made. Makes you lose all your emotion and decreases your IQ. Increases anxiety and depression and increases restlessness that does not go away after going off the drug. Completely messes up your GI system with terrible constipation, zero energy, inability to cry, decreases communication and you lose the ability to have any type of sex life. Big pharma should be ashamed to have this available. I would give it a zero if I could."

• SNewMe
• Taken for less than 1 month
• October 1, 2015

Zyprexa (olanzapine) "I am 5'3" tall and weigh 94lbs. I was prescribed several different antidepressants over a span of ten years along with Klonopin 1mg tid and Remeron 45mgs at bedtime for anxiety. I finally decided to see a Psychiatrist and she put me on 2.5mg of Zyprexa at bedtime. Just one dose and I was a completely different person! I woke up rested, smiling, happy, energized and a sense of well being again! This drug was like night and day for me! I am now on day 5 and I just keep feeling better! I am doing things I never dreamed I would and was able to get the job I've always wanted! For me, Zyprexa has truly changed my life and I hope it helps others the way it has helped me! The only side effect I've had is increased appetite (which I needed). :)"

• Jillpp
• Taken for 1 to 6 months
• January 3, 2024

Zyprexa (olanzapine) "Hello, I was put on Zyprexa 12.5 mg this past summer when I was hospitalized. Along with Nortriptyline, it saved my life. I was constantly anxious and suicidal. Zyprexa does increase your appetite, but if you count calories, avoid binging, and take Metformin 500 mg twice daily, you don’t have to gain weight. I also exercise daily. Zyprexa worked on everything: Anxiety, depression, and insomnia. It’s mildly sedating, but won’t knock you out like Seroquel will. These meds are a tricky business, and I wish all of you well. Hang in there if you’re suffering."

• DPDR...
• Taken for less than 1 month
• October 19, 2015

Zyprexa (olanzapine) "Zyprexa has been a life-saver. I was literally to the brink of suicide because of my Major Depression, Generalized Anxiety, slight Bipolar II, OCD, PTSD, and Depersonalization/Derealization. I have been on it for about a week and I feel complete difference already. No more night terrors, no more worry about the littlest things, no more feeling anxious around people, and no more not feeling like my bad self again. I feel the best I've felt in 2 years cause of this! All my symptoms have gone away with little sode effects, despite the weight gain and a lethargy an hour after taking it. I take at night, 5 mgs, I may start taking 2.5 mgs in the morning to help the morning edge off. I heard allot about the diabetes, hope it doesn't happen to me."

• annou...
• Taken for 1 to 6 months
• January 17, 2023

Zyprexa (olanzapine) "This medication is so annoying. I was on a low mg and didn’t feel a difference at all but when it finally got upped just by .5 I felt SO irritable. Also gained massive weight on it and i barely ate. I have horrible eating habits as it is to where I eat maybe twice at max a day but I gained 45 lbs on this medication in the span of not even two months. I was on 5 mg."

• Jenee
• Taken for 1 to 6 months
• August 29, 2020

Zyprexa (olanzapine) "I've been trying different meds for anxiety for years. I have debilitating anxiety and depression. Zyprexa started out great, my head cleared of the perpetual fog and I was able to function. Two weeks later I started becoming a zombie and my hair started falling out. It's been a month now, I'm now on Seroquel, gaining weight and my hair is still falling out by the hand full. I simply don't know what to do."

• Steve...
• Taken for less than 1 month
• April 21, 2015

Zyprexa (olanzapine) "For the amount of calmness I got from this drug, I was still physically alert and able. That's more than can say for most antipsychotics. It helped me sleep, and the following day my anxieties were lessened. I also found weird glimmers of hope in things, that had to be my depression lifting. It's a miracle to me. However, I gained 20 pounds in one month, and the doctor saw that as a reason to get me off the drug. Food had this crazy magnetism about it; it quickly became the most valuable thing on the planet, and I was having cravings for food unlike anything I've ever craved. If you can take the drug without binge eating, congratulations, because it works. Still, most people on this are overweight."

• zipper
• Taken for less than 1 month
• October 8, 2022

"I took 2.5mg took me out of the most severe depression I have experienced when SSRIs did not work. I do not feel completely back to normal but at least it helps me function a little instead of being a vegetable."

• Worth...
• Taken for less than 1 month
• December 10, 2015

"A lifetime of propensity to depression, then A MIRACLE 24 hours after my first 2.5 dose of Olanzapine combined with 100mg of Sertraline (been on that for years). I have my life back! Yes, there are a few side effects but they are in the main handleable/controllable and certainly better than the desire to die. The last 5 years of excruciating fear, shaking, crying, not showering/dressing. Staring at television all day, taking sleeping pills to keep me out of the world and avoid suicide. Name an anti-depressant and there's an 80% chance I've been on it! 6 weeks in private hospital this summer. Within a week of release I was back to the couch and my blanket. God bless my new GP for prescribing this!!"

• Reall...
• Taken for 2 to 5 years
• February 22, 2020

Zyprexa (olanzapine) "I started taking zyprexa when I was hospitalized for suicide. It worked, I felt less suicidal because I felt more dull. Zyprexa is a medication meant for short time use and many people end up on it for years and years. It acts a sexual suppressant though, which I didn’t notice until I was off of it and suddenly felt more easily turned on. It is very hard to get off it and has some side effects; it took me 1 yr to taper it down and when I finally got off of it I am now having terrible issues sleeping."

• Zzzach
• Taken for 1 to 6 months
• May 29, 2017

Zyprexa (olanzapine) "Avoid this like the plague! I have had irreversible damage to my metabolic system because of this medication including my thyroid. Evidence came out after the medications release that they hid these symptoms to get a quick release. Gained 30lbs in 2 months on this. I weaned off 10 years ago and am still dealing with the ramifications of this drug. Not worth it."

• LDiddy
• Taken for 1 to 2 years
• September 21, 2023

Zyprexa (olanzapine) "This medication saved me. I am off it now, but I had been on it for a little over a year. It straightened my brain out, pulled me out of a nervous breakdown, and did NOT aggravate joint and muscle pain - which Abilify and Seroquel gave me. It balanced me and enabled me to live a full life. It made me sleepy, so I took it at night. The only bad thing about this drug for me was the weight gain. It made me so damn hungry. I gained 60 lbs and it won't come off. My doctor ended up taking me off it due to that, but otherwise it's an incredible medicine and it does its job. So grateful for it. Also, what helped me out of a nervous breakdown was therapy, medicine, journaling, and getting outside often. Slowly I've been able to recoup and let go of each crutch. There is hope and you can do this!"

• Hira
• Taken for 1 to 2 years
• April 25, 2022

"It's magical for me... 200% work olanzapine was the most powerful drug for anxiety or insomnia and get you down for easy sleep as well. It's been long I'm using olanzapine and it's completely changed my personality. However it's no matter for negative impact like weight gain but it’s ok. Thank you who made this drug for mood stability. I'm so happy always and thinking more more right for everyday life"

• JOH
• Taken for less than 1 month
• February 20, 2021

Zyprexa (olanzapine) "Do NOT take this medicine. It caused my dad to get diabetes, and I took it not knowing that it was the same medication and gave me a terrible reaction. I had to be rushed to the hospital. I couldn’t walk because I was so out of it. I started talking funny, I couldn’t focus, much less keep myself awake most of the time. This medicine is for schizophrenia patients NOT bipolar. This medication has lawsuits on it continually because of it causing so many issues"

• Kareb...
• Taken for less than 1 month
• November 5, 2019

Zyprexa (olanzapine) "So I don't know if I'm alone here, but Zyprexa gave me very strange, borderline psychotic symptoms. I started having thoughts of tripping people or pushing them, complete strangers, btw...these thoughts came out of nowhere. I took it for about a month and had to stop taking it out of fear that it would get worse. I told my doc about this and he said it wasn't a typical reaction but I know what I felt..."

• Jim
• August 22, 2022

"I have had major depressive disorder pretty much all of my life. I am a 66-year-old male been married 43 years four children successful career but I have battled depression all my life. I had a recent bout and it was a strong one I began about 3 months ago. I tried increasing doses of trintellix Wellbutrin and other things that did not work. I was put on Fluoxetine 20 then 40 milligrams and that started to help but it just was not enough. My doctor upped my dosage to 60mg and it was just too much caused measure anxiety and I had to bounce back to the 40 mg. About a week ago I was put on 5 mg of olanzapine. Sounds too good to be true but in only one week I feel as normal as I have felt in a long long time. They say just like most medicines it takes 4 to 6 weeks to reach optimal efficacy. But I also read where some people do see Improvement in less than a week and I was one of those fortunate ones. Olanzapine is working like a miracle for me please don't be afraid to give it a try. Good luck"

• Nico
• Taken for less than 1 month
• June 4, 2021

"I’ve suffered from severe depression and anxiety for such a long time. I am only 22 years old but I have tried several antidepressants already. I was put on Escitalopram 20 mg but it seemed it wasn’t doing enough for my condition. My doc suggested me to take 2.5 mg of Olanzapine alongside with my antidepressant. I felt a relief from the first days. It was pretty unbelievable for me. My obsessive thoughts were not so violent and frequent anymore, I could laugh, make jokes, be present, do sports, cook etc. I felt the desire to go out and do things, which was a pretty big step for me. I am so thankful for this drug. I really hope it will get even better and better."

• Kathush
• June 30, 2022

Zyprexa (olanzapine) "I was put on this medicine Zyprexa @ 5 mg. a day. I took it at night before bed. I slept hard on this med and woke up feeling better after about 6 days on it. My mental health was better but I gained too much weight and was worried about my cholesterol levels. Pdoc decided to start the taper and now I'm falling back into that deep depression yet again. Now what?"

• satyam
• February 17, 2018

"To say olanzapine is either good or bad is too simplistic. When times were rough (and they were very rough indeed!) this drug did help me to carry on living. However, as I recovered, at some stage I felt the awful side-effects were not worth continuing it. Incredible weight gain (6 stone in total) was just one of them. It also dumbed me down a lot, I wasn't as alert anymore, had problems concentrating - but I slept like a log. Came off this drug completely about 2 months ago and I feel a lot better for it! Feels like I'm me again. People have commented on how I smile and laugh a lot more. I have much more energy and don't need a nap in the afternoon anymore. Overall, I feel this drug can be helpful in the short term, but, at least for me, it's not a long-term option!"

• tonio
• Taken for less than 1 month
• July 7, 2016

Zyprexa (olanzapine) "this drug didnt do shit to me. it actually made me feeling worse. my doctor doesnt want to take me off it. ive been taking it for 3 weeks for anxiety and hasnt done anything. plus i have put on 7 kilos. my dosage is 7.5 mg."

• Beth
• Taken for 2 to 5 years
• September 24, 2021

Zyprexa (olanzapine) "I had an episode of major depressive disorder and was given this med. I weighed 154 and have never had a weight problem. Within about 6-8 months I gained 60 pounds! It increases your appetite but also slows your metabolism by a lot. At the higher doses I had stomach issues like diarrhea daily. I had bad nausea 90% of every day and lived on ginger. We’ve been lowering it now very slowly for a few months and I completely stopped it 2 weeks ago. The side effects are terrible. I’ve missed so much work as I’ve had horrible migraines, weakness, shakiness, etc…. This is a horrible medication!!!"

• Town
• Taken for 1 to 6 months
• October 7, 2018

"Been on 2.5mg for 5 months due to anxiety and agitation. It’s helped no doubt. Sleep is rock solid, 8 hours every night and zero weight gain. I train 5 days a week rotating cardio and weight training. I also take 45 mg mirtazapine for depression. Hopefully there is no poop out with this drug. My Pdoc and plan to come off when I have healed enough."

• sano
• Taken for less than 1 month
• August 16, 2019

"On olanazpine I felt like I had been labotomized. I felt sad and unmotivated as usual but I could not bring my self to cry or express any pent up feelings. I could not cry at all no matter how hard I tried, it freaked me out."

• Happy...
• Taken for 1 to 6 months
• December 13, 2017

Zyprexa (olanzapine) "Wow this medication has helped me tremendously lower my anxiety and actually enjoy going out and the intrusive thoughts have not disappeared totally but I am able to shrug them off. I was taking 2.5mg in the morning and 2.5 at night but successfully decreased by half for day and night.CBT has helped as well. I am not a doctor but if your debating on if you should take it I would. The weight gain is a side effect but I have managed by limiting to 3 meals a day and not having any sweets in the house. Take note I am also on Cipralex and Lamotrigine so the cocktail of meds is helping alot"

• Kat
• Taken for 1 to 6 months
• July 11, 2016

"My depression was so bad my anxiety became horrible and also developed scary thoughts . I tried a few different pills and each one after 3 days I had to stop them due to Bad side effects I was then put on zyprexa 2.5mg and did not expect much from them but I was surprised ! First day I did not feel any different but by day 3 I felt a little better and started day 4 broke my pill record ! I'm on day 7 now and feel a lot better ! I feel like me again I still have some anxiety but it's bearable :) and the bad thoughts seem to get blocked out when starting :) . still no bad side effects I have had a few dizzy moments when bending over and getting up to fast but it passes fast :) I'm glad I started this pill wish it was the first one I tried !!"