Olanzapine (Oral)
Generic name: olanzapine [ oh-LAN-za-peen ]
Brand names: ZyPREXA, ZyPREXA Zydis
Drug class: Atypical antipsychotics
Medically reviewed by Drugs.com. Last updated on Jan 20, 2024.
Risk of death is increased in elderly patients with dementia-related psychosis treated with antipsychotic drugs. Although the causes of death in clinical trials were varied, most of the deaths appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. Observational studies suggest that antipsychotic drugs may increase mortality. It is unclear from these studies to what extent the mortality findings may be attributed to the antipsychotic drug as opposed to patient characteristics. Olanzapine is not approved for the treatment of patients with dementia-related psychosis .
Uses for olanzapine
Olanzapine is used to treat schizophrenia. It may also be used alone or with other medicines (eg, lithium or valproate) to treat mania or mixed episodes that is part of bipolar disorder (manic-depressive illness). Olanzapine may also be used together with fluoxetine to treat depression that is a part of bipolar disorder, and depression in patients who received other antidepressants that did not work well. This medicine should not be used to treat behavioral problems in older adult patients who have dementia or Alzheimer's disease.
This medicine is available only with your doctor's prescription.
Before using olanzapine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of olanzapine in children. However, safety and efficacy of olanzapine alone in children younger than 13 years of age and olanzapine and fluoxetine combination in children younger than 10 years of age have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of olanzapine in the elderly. However, elderly patients are more likely to have dementia or age-related liver, kidney, or heart problems, which may require caution or an adjustment in the dose for patients receiving olanzapine.
Breast Feeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Bepridil
- Bromopride
- Cisapride
- Dronedarone
- Levoketoconazole
- Levomethadyl
- Metoclopramide
- Pimozide
- Piperaquine
- Potassium Citrate
- Saquinavir
- Sparfloxacin
- Terfenadine
- Thioridazine
- Ziprasidone
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abametapir
- Acepromazine
- Adagrasib
- Alfentanil
- Alfuzosin
- Alprazolam
- Amantadine
- Amiodarone
- Amisulpride
- Amitriptyline
- Amobarbital
- Anagrelide
- Anileridine
- Apalutamide
- Apomorphine
- Apomorphine Hydrochloride
- Aripiprazole
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Asenapine
- Astemizole
- Atazanavir
- Azithromycin
- Baclofen
- Bedaquiline
- Benperidol
- Benzhydrocodone
- Bromazepam
- Bromocriptine Mesylate
- Buprenorphine
- Bupropion
- Buserelin
- Buspirone
- Butabarbital
- Butorphanol
- Cabergoline
- Calcium Oxybate
- Cannabidiol
- Cannabis
- Capmatinib
- Carbamazepine
- Carbinoxamine
- Carisoprodol
- Carphenazine
- Ceritinib
- Cetirizine
- Chloral Hydrate
- Chlordiazepoxide
- Chloroquine
- Chlorpromazine
- Chlorzoxazone
- Ciprofloxacin
- Citalopram
- Clarithromycin
- Clobazam
- Clofazimine
- Clomipramine
- Clonazepam
- Clorazepate
- Clothiapine
- Clozapine
- Cobicistat
- Codeine
- Crizotinib
- Cyclobenzaprine
- Dabrafenib
- Daridorexant
- Dasatinib
- Degarelix
- Delamanid
- Desipramine
- Deslorelin
- Deutetrabenazine
- Dexmedetomidine
- Diacetylmorphine
- Diazepam
- Dichloralphenazone
- Difenoxin
- Dihydrocodeine
- Diphenhydramine
- Diphenoxylate
- Disopyramide
- Dofetilide
- Dolasetron
- Domperidone
- Donepezil
- Doxepin
- Doxylamine
- Droperidol
- Ebastine
- Efavirenz
- Encorafenib
- Enflurane
- Enoxacin
- Entrectinib
- Enzalutamide
- Eribulin
- Erythromycin
- Escitalopram
- Esketamine
- Estazolam
- Eszopiclone
- Ethchlorvynol
- Ethopropazine
- Ethylmorphine
- Etrasimod
- Famotidine
- Felbamate
- Fenoldopam Mesylate
- Fentanyl
- Fexinidazole
- Fingolimod
- Flecainide
- Flibanserin
- Fluconazole
- Flunitrazepam
- Fluoxetine
- Fluphenazine
- Flurazepam
- Fluspirilene
- Fluvoxamine
- Formoterol
- Foscarnet
- Fosphenytoin
- Fospropofol
- Fostemsavir
- Gabapentin
- Gabapentin Enacarbil
- Galantamine
- Gatifloxacin
- Gemifloxacin
- Gepirone
- Glasdegib
- Glucagon
- Glycopyrrolate
- Glycopyrronium Tosylate
- Gonadorelin
- Goserelin
- Granisetron
- Halazepam
- Halofantrine
- Haloperidol
- Halothane
- Hexobarbital
- Histrelin
- Hydrocodone
- Hydromorphone
- Hydroquinidine
- Hydroxychloroquine
- Hydroxyzine
- Ibutilide
- Iloperidone
- Imipramine
- Inotuzumab Ozogamicin
- Isoflurane
- Itraconazole
- Ivabradine
- Ivosidenib
- Ketamine
- Ketazolam
- Ketobemidone
- Ketoconazole
- Lacosamide
- Lapatinib
- Lefamulin
- Lemborexant
- Lenvatinib
- Leuprolide
- Levocetirizine
- Levodopa
- Levofloxacin
- Levorphanol
- Lithium
- Lofexidine
- Loxapine
- Lumacaftor
- Lumefantrine
- Macimorelin
- Magnesium Oxybate
- Meclizine
- Mefloquine
- Melperone
- Meperidine
- Mephobarbital
- Meprobamate
- Meptazinol
- Mesoridazine
- Metaxalone
- Methacholine
- Methadone
- Methdilazine
- Methocarbamol
- Methohexital
- Methotrimeprazine
- Methylene Blue
- Metronidazole
- Mifepristone
- Mirtazapine
- Mitotane
- Mizolastine
- Mobocertinib
- Molindone
- Moricizine
- Morphine
- Morphine Sulfate Liposome
- Moxifloxacin
- Nafarelin
- Nalbuphine
- Nelfinavir
- Nicomorphine
- Nilotinib
- Nitrazepam
- Nitrous Oxide
- Norfloxacin
- Octreotide
- Ofloxacin
- Omeprazole
- Ondansetron
- Opium
- Opium Alkaloids
- Orphenadrine
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxazepam
- Oxycodone
- Oxymorphone
- Ozanimod
- Pacritinib
- Paliperidone
- Panobinostat
- Papaveretum
- Papaverine
- Paregoric
- Paroxetine
- Pasireotide
- Pazopanib
- Pentamidine
- Pentazocine
- Pentobarbital
- Perampanel
- Perazine
- Periciazine
- Perphenazine
- Phenobarbital
- Phenytoin
- Pimavanserin
- Pipamperone
- Piperacetazine
- Pipotiazine
- Piritramide
- Pitolisant
- Pixantrone
- Ponesimod
- Posaconazole
- Potassium Oxybate
- Pramipexole Dihydrochloride
- Prazepam
- Pregabalin
- Primidone
- Probucol
- Procainamide
- Prochlorperazine
- Promazine
- Promethazine
- Propafenone
- Propofol
- Protriptyline
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Quizartinib
- Ramelteon
- Ranolazine
- Relugolix
- Remifentanil
- Remimazolam
- Remoxipride
- Revefenacin
- Ribociclib
- Rifampin
- Risperidone
- Ritonavir
- Ropeginterferon Alfa-2b-njft
- Ropinirole Hydrochloride
- Rotigotine
- Scopolamine
- Secobarbital
- Secretin Human
- Selpercatinib
- Sertindole
- Sertraline
- Sevoflurane
- Siponimod
- Sodium Oxybate
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- Solifenacin
- Sorafenib
- Sotalol
- St John's Wort
- Sufentanil
- Sulpiride
- Sultopride
- Sunitinib
- Suvorexant
- Tacrolimus
- Tamoxifen
- Tapentadol
- Telaprevir
- Telavancin
- Telithromycin
- Temazepam
- Tetrabenazine
- Thiethylperazine
- Thiopental
- Thiopropazate
- Tilidine
- Tiotropium
- Tizanidine
- Tolonium Chloride
- Tolterodine
- Topiramate
- Toremifene
- Tramadol
- Trazodone
- Triazolam
- Triclabendazole
- Trifluoperazine
- Trifluperidol
- Triflupromazine
- Trimeprazine
- Trimipramine
- Triptorelin
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Vilanterol
- Vinflunine
- Voclosporin
- Voriconazole
- Vorinostat
- Zaleplon
- Zolpidem
- Zopiclone
- Zotepine
- Zuclopenthixol
- Zuranolone
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Amprenavir
- Betel Nut
- Fosamprenavir
- Valproic Acid
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
- Ethanol
- Tobacco
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Blood vessel disease or circulation problems or
- Dehydration or
- Heart attack or stroke, history of or
- Heart disease or
- Heart failure or
- Heart rhythm problems or
- Hypotension (low blood pressure) or
- Hypovolemia (low blood volume)—May cause side effects to become worse.
- Breast cancer, prolactin-dependent or
- Glaucoma, narrow-angle or
- Hyperlipidemia (high cholesterol or fat in the blood) or
- Hyperprolactinemia (high prolactin in the blood) or
- Liver disease or
- Paralytic ileus (severe intestinal problem), or history of or
- Prostatic hypertrophy (enlarged prostate), or history of or
- Seizures, history of or
- Urinary retention (problems with passing urine), or history of—Use with caution. This medicine may make these conditions worse.
- Diabetes or
- Hyperglycemia (high blood sugar)—Use with caution. This medicine may raise blood sugar levels.
- Phenylketonuria (PKU, a genetic disease of metabolism)—The orally disintegrating tablet (Zyprexa® Zydis®) contains phenylalanine, which can make this condition worse.
Proper use of olanzapine
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the medication guide if you do not have one.
If you are using the orally disintegrating tablet (Zyprexa® Zydis®), make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Do not push the tablet through the foil. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, swallow or take a sip of water.
You may take this medicine with or without food.
Tell your doctor if you smoke tobacco. You might need a different amount of this medicine if you smoke.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage forms (orally disintegrating tablets, regular tablets):
- For treatment of schizophrenia:
- Adults—At first, 5 to 10 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
- Children 13 to 17 years of age—At first, 2.5 or 5 mg once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
- Children younger than 13 years of age—Use and dose must be determined by your doctor.
- For treatment of mania or mixed episodes with bipolar disorder (olanzapine alone):
- Adults—At first, 10 to 15 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
- Children 13 to 17 years of age—At first, 2.5 or 5 mg once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
- Children younger than 13 years of age—Use and dose must be determined by your doctor.
- For treatment of mania or mixed episodes with bipolar disorder (olanzapine with lithium or valproate):
- Adults—At first, 10 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
- Children—Use and dose must be determined by your doctor.
- For treatment of depression with bipolar disorder (olanzapine with fluoxetine):
- Adults—At first, 5 milligrams (mg) of olanzapine and 20 mg of fluoxetine once a day in the evening. Your doctor may adjust your dose as needed. However the dose is usually not more than 18 mg of olanzapine and 75 mg of fluoxetine per day.
- Children 10 to 17 years of age—At first, 2.5 milligrams (mg) of olanzapine and 20 mg of fluoxetine once a day in the evening. Your doctor may adjust your dose as needed. However the dose is usually not more than 12 mg of olanzapine and 50 mg of fluoxetine per day.
- Children younger than 10 years of age—Use and dose must be determined by your doctor.
- For treatment resistant depression (olanzapine with fluoxetine):
- Adults—At first, 5 milligrams (mg) of olanzapine and 20 mg of fluoxetine once a day in the evening. Your doctor may adjust your dose as needed. However the dose is usually not more than 18 mg of olanzapine and 75 mg of fluoxetine per day.
- Children—Use and dose must be determined by your doctor.
- For treatment of schizophrenia:
Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Related/similar drugs
Vraylar, sertraline, trazodone, hydroxyzine, quetiapine, ondansetron, lamotrigine, Lexapro, citalopram, lorazepam
Precautions while using olanzapine
It is very important that your doctor check your or your child's progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Olanzapine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these unwanted effects, tell your doctor right away.
This medicine may cause a condition called drug reaction with eosinophilia and systemic symptoms (DRESS). Call your doctor right away if you have a rash, red, swollen skin, fever, chills, cough, trouble breathing, swollen glands, or unusual bleeding, bruising, or weakness after using this medicine.
This medicine may increase the amount of sugar in your blood. Check with your doctor right away if you have increased thirst or increased urination. If you or your child have diabetes, you may notice a change in the results of your urine or blood sugar tests. If you have any questions, check with your doctor.
This medicine may increase your cholesterol and fats in the blood. If this condition occurs, your doctor may give you or your child some medicines that can lower the amount of cholesterol and fats in the blood.
This medicine may increase your weight. Your doctor may need to check your or your child's weight on a regular basis while you are using this medicine.
Check with your doctor right away if you have difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, seizures, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).
This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you or your child have lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.
Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.
This medicine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor immediately if you or your child think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
Olanzapine may cause drowsiness, trouble with thinking, trouble with controlling body movements, or trouble with your vision, which may lead to falls, fractures or other injuries. Make sure you know how you react to this medicine before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well.
This medicine may add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicines for allergies or colds, sedatives, tranquilizers, or sleeping medicines, prescription pain medicines or narcotics, medicines for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any CNS depressants while you are taking this medicine.
This medicine may make it more difficult for your body to cool down. It might reduce how much you sweat. Your body could get too hot if you do not sweat enough. If your body gets too hot, you might feel dizzy, weak, tired, or confused. You might vomit or have an upset stomach. Do not get too hot while you are exercising. Avoid places that are very hot. Call your doctor if you are too hot and can not cool down.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines) and herbal or vitamin supplements.
Side Effects of olanzapine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- blurred vision
- change in vision
- change in walking and balance
- clumsiness or unsteadiness
- difficulty with speaking
- difficulty with swallowing
- drooling
- impaired vision
- inability to sit still
- loss of balance control
- mask-like face
- muscle trembling, jerking, or stiffness
- need to keep moving
- rapid weight gain
- restlessness
- shuffling walk
- slowed movements
- slurred speech
- stiffness of the arms and legs
- tic-like (jerky) movements of the head, face, mouth, and neck
- tingling of the hands or feet
- trembling or shaking of the fingers, hands, feet, legs, or arms
- twisting movements of the body
- uncontrolled movements, especially of the face, neck, and back
- unusual weight gain or loss
Less common
- Bladder pain
- bloody or cloudy urine
- bruising
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain
- difficult or labored breathing
- difficult, burning, or painful urination
- dizziness
- excessive muscle tone
- frequent urge to urinate
- headache
- inability to move the eyes
- increased blinking or spasms of the eyelid
- itching of the vagina or genital area
- lack of coordination
- large, flat, blue, or purplish patches in the skin
- loss of bladder control
- loss of memory
- lower back or side pain
- muscle tension or tightness
- nervousness
- pain during sexual intercourse
- pounding in the ears
- problems with memory
- rhythmic movement of the muscles
- slow, fast, pounding, or irregular heartbeat or pulse
- speaking is less clear than usual
- sticking out the tongue
- thick, white vaginal discharge with no odor or with a mild odor
- tightness in the chest
- twitching
- uncontrolled twisting movements of the neck, trunk, arms, or legs
- unusual or incomplete body or facial movements
- weakness of the arms and legs
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Acid or sour stomach
- back pain
- belching
- change in personality
- difficulty having a bowel movement (stool)
- discouragement
- feeling sad or empty
- fever
- heartburn
- increased appetite
- increased cough
- indigestion
- lack of appetite
- lack or loss of strength
- loss of interest or pleasure
- runny nose
- sneezing
- stomach discomfort, upset, or pain
- stuffy nose
- thirst
- trouble sleeping
- trouble with concentrating
- watering of the mouth
Less common
- Blemishes on the skin
- body aches or pain
- chills
- cold sweats
- congestion
- cough
- dry skin
- dryness or soreness of the throat
- false or unusual sense of well-being
- heavy menstrual bleeding (periods)
- hoarseness
- joint pain
- lack of feeling or emotion
- leg cramps
- pain in the arms or legs
- pimples
- sweating
- tender, swollen glands in the neck
- uncaring feelings
- voice change
- vomiting
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Commonly used brand name(s)
In the U.S.
- ZyPREXA
- ZyPREXA Zydis
Available Dosage Forms:
- Tablet, Disintegrating
- Tablet
Therapeutic Class: Antipsychotic
Chemical Class: Thienobenzodiazepine
More about olanzapine
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (1,072)
- Drug images
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: atypical antipsychotics
- Breastfeeding
Patient resources
- Olanzapine drug information
- Olanzapine injection
- Olanzapine (Intramuscular) (Advanced Reading)
- Olanzapine Orally Disintegrating Tablets
- Olanzapine Extended-Release Injection
Other brands
Zyprexa, Zyprexa Relprevv, Zyprexa Intramuscular
Professional resources
- Olanzapine monograph
- Olanzapine Injection (FDA)
- Olanzapine Orally Disintegrating Tablets (FDA)
- Olanzapine Tablets (FDA)
Other brands
Related treatment guides
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.