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Vilazodone Side Effects

Medically reviewed by Last updated on Sep 25, 2023.

Applies to vilazodone: oral tablet.


Oral route (Tablet)

Antidepressants can increase the risk of suicidal thinking and behavior in pediatric and young adult patients. Closely monitor patients of all ages for clinical worsening and for emergence of suicidal thoughts and behaviors. Vilazodone hydrochloride is not approved for use in pediatric patients.

Serious side effects of Vilazodone

Along with its needed effects, vilazodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vilazodone:

Less common

Other side effects of Vilazodone

Some side effects of vilazodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Incidence not known

For Healthcare Professionals

Applies to vilazodone: oral kit, oral tablet.


The most commonly observed side effects were: diarrhea, nausea, headache, and dry mouth.[Ref]


Very common (10% or more): Diarrhea (up to 29%), nausea (up to 24%)

Common (1% to 10%): Abdominal distension, abdominal pain, pain, dry mouth, dyspepsia, flatulence, gastroenteritis, vomiting

Frequency not reported: Abdominal discomfort, acute pancreatitis, upper abdominal pain[Ref]

Nervous system

Very common (10% or more): Headache (up to 15%)

Common (1% to 10%): Dizziness, paresthesia, sedation, somnolence, tremor

Uncommon (0.1% to 1%): Migraine, serotonin syndrome

Frequency not reported: Akathisia, paresthesia/electric shock sensation, restless legs syndrome, sensory disturbances

Postmarketing reports: Sleep paralysis[Ref]


Common (1% to 10%): Abnormal dreams, abnormal orgasm, decreased libido, insomnia, restlessness

Uncommon (0.1% to 1%): Activation of mania/hypomania, panic attack

Frequency not reported: Agitation, anorgasmia, anxiety, clinical worsening, confusion, discontinuation symptoms, dysphoric mood, emotional lability, lethargy, seizures, suicide risk

Postmarketing reports: Irritability, hallucinations, suicide attempt, suicidal ideation[Ref]


Common (1% to 10%): Increased appetite, increased weight

Frequency not reported: Hyponatremia[Ref]


Common (1% to 10%): Ejaculation disorder, erectile dysfunction[Ref]


Common (1% to 10%): Palpitations

Uncommon (0.1% to 1%): Ventricular extrasystoles[Ref]


Common (1% to 10%): Fatigue

Uncommon (0.1% to 1%): Tinnitus[Ref]


Common (1% to 10%): Arthralgia[Ref]


Uncommon (0.1% to 1%): Blurred vision, dry eye

Rare (0.01% to 0.1%): Cataracts[Ref]


Uncommon (0.1% to 1%): Hyperhidrosis, night sweats

Postmarketing reports: Drug eruption, generalized rash, rash, urticaria[Ref]


Frequency not reported: Abnormal Bleeding[Ref]

Frequently asked questions


1. Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC. 2011.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.