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Vilazodone Side Effects

Medically reviewed by Last updated on May 19, 2020.

In Summary

Commonly reported side effects of vilazodone include: diarrhea and nausea. Other side effects include: dizziness, insomnia, and abnormal dreams. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to vilazodone: oral tablet


Oral route (Tablet)

Antidepressants can increase the risk of suicidal thinking and behavior in pediatric and young adult patients. Closely monitor patients of all ages for clinical worsening and for emergence of suicidal thoughts and behaviors. Vilazodone hydrochloride is not approved for use in pediatric patients.

Side effects requiring immediate medical attention

Along with its needed effects, vilazodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vilazodone:

Less common

  • Actions that are out of control
  • anxiety
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • extra heartbeat
  • fast, irregular, pounding, or racing heartbeat or pulse
  • irritability
  • shakiness in the legs, arms, hands, or feet
  • sweating
  • talking, feeling, and acting with excitement
  • trembling or shaking of the hands or feet

Side effects not requiring immediate medical attention

Some side effects of vilazodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

  • Abdominal or stomach pain
  • abnormal dreams
  • aching or discomfort in the lower legs or sensation of crawling in the legs
  • acid or sour stomach
  • belching
  • blindness
  • bloated or full feeling
  • blurred vision
  • change in taste
  • decreased interest in sexual intercourse
  • decreased vision
  • difficulty with moving
  • drowsiness
  • dry eyes
  • excess air or gas in the stomach or intestines
  • feeling jittery
  • headache, severe and throbbing
  • heartburn
  • inability to have or keep an erection
  • increased or decreased appetite
  • increased sweating
  • indigestion
  • loss in sexual ability, desire, drive, or performance
  • loss of appetite
  • loss of taste
  • muscle pain or stiffness
  • night sweats
  • not able to have an orgasm
  • pain in the joints
  • passing gas
  • relaxed and calm
  • restlessness
  • sleepiness or unusual drowsiness
  • stomach discomfort or upset
  • unusual tiredness or weakness
  • vomiting
  • weakness

Incidence not known

For Healthcare Professionals

Applies to vilazodone: oral kit, oral tablet


The most commonly observed side effects were: diarrhea, nausea, headache, and dry mouth.[Ref]


Very common (10% or more): Diarrhea (up to 29%), nausea (up to 24%)

Common (1% to 10%): Abdominal distension, abdominal pain, pain, dry mouth, dyspepsia, flatulence, gastroenteritis, vomiting

Frequency not reported: Abdominal discomfort, acute pancreatitis, upper abdominal pain[Ref]

Nervous system

Very common (10% or more): Headache (up to 15%)

Common (1% to 10%): Dizziness, paresthesia, sedation, somnolence, tremor

Uncommon (0.1% to 1%): Migraine, serotonin syndrome

Frequency not reported: Akathisia, paresthesia/electric shock sensation, restless legs syndrome, sensory disturbances

Postmarketing reports: Sleep paralysis[Ref]


Common (1% to 10%): Abnormal dreams, abnormal orgasm, decreased libido, insomnia, restlessness

Uncommon (0.1% to 1%): Activation of mania/hypomania, panic attack

Frequency not reported: Agitation, anorgasmia, anxiety, clinical worsening, confusion, discontinuation symptoms, dysphoric mood, emotional lability, lethargy, seizures, suicide risk

Postmarketing reports: Irritability, hallucinations, suicide attempt, suicidal ideation[Ref]


Common (1% to 10%): Increased appetite, increased weight

Frequency not reported: Hyponatremia[Ref]


Common (1% to 10%): Ejaculation disorder, erectile dysfunction[Ref]


Common (1% to 10%): Palpitations

Uncommon (0.1% to 1%): Ventricular extrasystoles[Ref]


Common (1% to 10%): Fatigue

Uncommon (0.1% to 1%): Tinnitus[Ref]


Common (1% to 10%): Arthralgia[Ref]


Uncommon (0.1% to 1%): Blurred vision, dry eye

Rare (0.01% to 0.1%): Cataracts[Ref]


Uncommon (0.1% to 1%): Hyperhidrosis, night sweats

Postmarketing reports: Drug eruption, generalized rash, rash, urticaria[Ref]


Frequency not reported: Abnormal Bleeding[Ref]


1. "Product Information. Viibryd (vilazodone)." Trovis Pharmaceuticals LLC, New Haven, CT.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.