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Vilazodone Side Effects

In Summary

Commonly reported side effects of vilazodone include: diarrhea and nausea. Other side effects include: dizziness, insomnia, and abnormal dreams. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to vilazodone: oral tablet

As well as its needed effects, vilazodone may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking vilazodone, check with your doctor immediately:

Less common:
  • Actions that are out of control
  • anxiety
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • extra heartbeat
  • fast, irregular, pounding, or racing heartbeat or pulse
  • irritability
  • shakiness in the legs, arms, hands, or feet
  • sweating
  • talking, feeling, and acting with excitement
  • trembling or shaking of the hands or feet

Minor Side Effects

Some vilazodone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Diarrhea
  • dizziness
  • dry mouth
  • nausea
  • trouble sleeping
Less common:
  • Abdominal or stomach pain
  • abnormal dreams
  • aching or discomfort in the lower legs or sensation of crawling in the legs
  • acid or sour stomach
  • belching
  • blindness
  • bloated or full feeling
  • blurred vision
  • change in taste
  • decreased interest in sexual intercourse
  • decreased vision
  • difficulty with moving
  • drowsiness
  • dry eyes
  • excess air or gas in the stomach or intestines
  • feeling jittery
  • headache, severe and throbbing
  • heartburn
  • inability to have or keep an erection
  • increased or decreased appetite
  • increased sweating
  • indigestion
  • loss in sexual ability, desire, drive, or performance
  • loss of appetite
  • loss of taste
  • muscle pain or stiffness
  • night sweats
  • not able to have an orgasm
  • pain in the joints
  • passing gas
  • relaxed and calm
  • restlessness
  • sleepiness or unusual drowsiness
  • stomach discomfort or upset
  • unusual tiredness or weakness
  • vomiting
  • weakness
Incidence not known:
  • Eye pain

For Healthcare Professionals

Applies to vilazodone: oral kit, oral tablet


Common (1% to 10%): Insomnia, abnormal dreams, decreased libido, restlessness, abnormal orgasm
Uncommon (0.1% to 1%): Panic attack, mania
Frequency not reported: Clinical worsening and suicide risk, activation of mania/hypomania, discontinuation symptoms [dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g., paresthesia, such as electric shock sensations), anxiety, confusion, headache, lethargy, emotional lability, insomnia, hypomania, tinnitus, and seizures]
Postmarketing reports: Irritability, hallucinations, suicide attempt, suicidal ideation[Ref]

Nervous system

Common (1% to 10%): Dizziness, somnolence, paresthesia, tremor, sedation, migraine
Uncommon (0.1% to 1%): Dysgeusia, serotonin syndrome
Frequency not reported: Seizure[Ref]


Common (1% to 10%): Palpitations
Uncommon (0.1% to 1%): Ventricular extrasystoles[Ref]


Very common (10% or more): Diarrhea (28%), nausea (23%)
Common (1% to 10%): Dry mouth, vomiting, dyspepsia, flatulence, gastroenteritis[Ref]


Common (1% to 10%): Delayed ejaculation, erectile dysfunction, decreased libido, abnormal orgasm, sexual dysfunction[Ref]


Common (1% to 10%): Arthralgia[Ref]


The most commonly observed side effects were: diarrhea, nausea, vomiting, and insomnia.[Ref]


Common (1% to 10%): Hyperhidrosis, night sweats[Ref]


Frequency not reported: Abnormal Bleeding[Ref]


Common (1% to 10%): Increased appetite, decreased appetite
Frequency not reported: Hyponatremia[Ref]


Common (1% to 10%): Blurred vision, dry eye
Uncommon (0.1% to 1%): Cataracts[Ref]


Common (1% to 10%): Fatigue, feeling jittery
Uncommon (0.1% to 1%): Feeling abnormal[Ref]


Uncommon (0.1% to 1%): Pollakiuria[Ref]


1. "Product Information. Viibryd (vilazodone)." Trovis Pharmaceuticals LLC, New Haven, CT.

It is possible that some side effects of vilazodone may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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