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Effexor Side Effects

Generic name: venlafaxine

Medically reviewed by Drugs.com. Last updated on Sep 23, 2024.

Note: This document provides detailed information about Effexor Side Effects associated with venlafaxine. Some dosage forms listed on this page may not apply specifically to the brand name Effexor.

Applies to venlafaxine: oral capsule extended release, oral tablet, oral tablet extended release.

Important warnings This medicine can cause some serious health issues

Oral route (capsule, extended release)

Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies.

Closely monitor all antidepressant-treated patients for clinical worsening, and emergence of suicidal thoughts and behaviors.

Venlafaxine hydrochloride is not approved for use in pediatric patients.

Oral route (tablet; tablet, extended release)

Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of Major Depressive Disorder (MDD) and other psychiatric disorders.

Anyone considering the use of venlafaxine hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need.

Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older.

Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide.

Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior.

Families and caregivers should be advised of the need for close observation and communication with the prescriber.

Venlafaxine is not approved for use in pediatric patients

Precautions

If you will be taking this medicine for a long time, it is very important that your doctor check you at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

Do not take venlafaxine (the active ingredient contained in Effexor) with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid (Marplan®), phenelzine (Nardil®)], selegiline (Eldepryl®), tranylcypromine (Parnate®)). Do not start taking venlafaxine during the 14 days after you stop a MAO inhibitor and wait 7 days after stopping venlafaxine before you start taking a MAO inhibitor. If you take them together or do not wait the proper amount of time, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body temperature, an extremely high blood pressure, or severe seizures.

Venlafaxine may cause a serious condition called serotonin syndrome if taken together with certain medicines. Do not use venlafaxine with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), linezolid (Zyvox®), lithium (Eskalith®, Lithobid®), methylene blue injection, tryptophan, St John's wort, amphetamines, or some pain or migraine medicines (eg, meperidine, methadone, rizatriptan, sumatriptan, tramadol, Demerol®, Frova®, Imitrex®, Maxalt®, Methadose®, Relpax®, Ultram®, Zomig®). Check with your doctor first before taking any other medicines with venlafaxine.

This medicine may cause some teenagers and young adults to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Some people may have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. If you or your caregiver notice any of these unwanted effects, tell your doctor right away. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.

Do not suddenly Stop taking venlafaxine without checking first with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. This will decrease the chance of side effects, including agitation, anxiety, blurred vision, confusion, diarrhea, dizziness, fast or irregular heartbeat, headache, irritability, nausea or vomiting, numbness or tingling feeling, restlessness, seizures, sweating, thoughts of hurting yourself or others, trouble sleeping, unusual dreams, or unusual drowsiness, tiredness, or weakness.

This medicine may cause hyponatremia (low sodium in the blood). This is more common in elderly patients, those who take diuretic medicines, or those who have a low amount of fluid in the body due to severe diarrhea or vomiting. Check with your doctor right away if you have a headache, trouble concentrating, memory problems, confusion, weakness, or feel unsteady when standing.

Venlafaxine may increase your risk for bleeding problems. Make sure your doctor knows if you are also using other medicines that thin the blood, including NSAIDs (eg, aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®) or warfarin (Coumadin®, Jantoven®).

Tell your doctor right away if you are having chest pain or discomfort, dry cough, fever, general feeling of tiredness or weakness, skin rash, or trouble breathing with this medicine. These might be symptoms of a serious lung problem, including interstitial lung disease and eosinophilic pneumonia.

Venlafaxine may cause some people to become drowsy or have blurred vision. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to see clearly. It is best to avoid alcohol with venlafaxine.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Check with your doctor right away if you have decreased interest in sexual intercourse, delayed or inability to have and orgasm in women, inability to have or keep an erection in men, or loss in sexual ability, desire, drive, or performance. These could be symptoms of sexual dysfunction.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Effexor

Along with its needed effects, venlafaxine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking venlafaxine:

More common side effects

  • change or problem with discharge of semen
  • decreased interest in sexual intercourse
  • inability to have or keep an erection
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • severe headache
  • sweating

Less common side effects

  • blurred vision
  • chest pain
  • delayed or inability to have an orgasm
  • fast or irregular heartbeat
  • mood or mental changes
  • ringing or buzzing in the ears
  • suicidal thoughts

Rare side effects

  • actions that are out of control
  • high fever
  • irritability
  • itching or skin rash
  • lightheadedness or fainting, especially when getting up suddenly from a sitting or lying position
  • menstrual changes
  • nervousness
  • problems with urinating or holding urine
  • seizures
  • severe muscle stiffness
  • talking, feeling, and acting with excitement that you cannot control
  • trouble breathing
  • unusually pale skin

Incidence not known

  • agitation
  • bloody, black, or tarry stools
  • bloody stool or urine
  • dark urine
  • decreased frequency or amount of urine
  • diarrhea
  • drowsiness
  • fever
  • general feeling of tiredness or weakness
  • headache
  • increased thirst
  • light-colored stools
  • muscle cramps, spasms, or pain
  • nausea or vomiting
  • nosebleeds
  • overactive reflexes
  • poor coordination
  • red or purple spots on the skin
  • restlessness
  • shivering
  • stomach pain on the upper right side
  • swelling of the face, lower legs, ankles, hands, or fingers
  • trembling or shaking that is hard to control
  • twitching
  • unusual bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • yellow eyes or skin

Other side effects of Effexor

Some side effects of venlafaxine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • abnormal dreams
  • chills
  • constipation
  • decrease in sexual desire or ability
  • diarrhea
  • dry mouth
  • heartburn
  • increased sweating
  • loss of appetite
  • nausea
  • stomach pain or gas
  • stuffy or runny nose
  • tingling, burning, or prickly sensations
  • trouble sleeping
  • vomiting
  • weight loss

Less common side effects

  • change in taste
  • muscle tension
  • yawning

Incidence not known

  • decrease in smell
  • loss of sense of smell
  • night sweats

For healthcare professionals

Applies to venlafaxine: oral capsule extended release, oral tablet, oral tablet extended release.

General adverse events

The most commonly reported side effects were nausea, headache, somnolence, and dizziness.[Ref]

Gastrointestinal

Nervous system

Psychiatric

Dermatologic

Metabolic

Other

Genitourinary

Cardiovascular

Respiratory

Ocular

Musculoskeletal

Immunologic

Hematologic

Hepatic

Renal

Hypersensitivity

Endocrine

Oncologic

See also:

References

1. (2001) "Product Information. Effexor (venlafaxine)." Wyeth-Ayerst Laboratories

2. (2002) "Product Information. Effexor XR (venlafaxine)." Wyeth-Ayerst Laboratories

3. Cerner Multum, Inc. "UK Summary of Product Characteristics."

4. Cerner Multum, Inc. "Australian Product Information."

Frequently asked questions

Further information

Effexor side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.