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Fluoxetine / Olanzapine Dosage

Medically reviewed by Drugs.com. Last updated on Mar 20, 2023.

Applies to the following strengths: 25 mg-3 mg; 25 mg-6 mg; 25 mg-12 mg; 50 mg-6 mg; 50 mg-12 mg

Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Depression

Initial Dose: Fluoxetine 25 mg-olanzapine 6 mg orally once a day
Maintenance dose: Adjust as clinically necessary to within a range of:

Maximum dose: Fluoxetine 50 mg-olanzapine 12 mg orally once a day
Duration: It is generally accepted that treatment-resistant depression and Bipolar I disorder, including the depressive episodes associated with Bipolar I disorder, are chronic illnesses requiring chronic treatment.

Comments:

Use: Acute treatment of treatment-resistant depression and depressive episodes associated with Bipolar I Disorder

Usual Adult Dose for Bipolar Disorder

Initial Dose: Fluoxetine 25 mg-olanzapine 6 mg orally once a day
Maintenance dose: Adjust as clinically necessary to within a range of:

Maximum dose: Fluoxetine 50 mg-olanzapine 12 mg orally once a day
Duration: It is generally accepted that treatment-resistant depression and Bipolar I disorder, including the depressive episodes associated with Bipolar I disorder, are chronic illnesses requiring chronic treatment.

Comments:

Use: Acute treatment of treatment-resistant depression and depressive episodes associated with Bipolar I Disorder

Usual Geriatric Dose for Depression

Initial Dose: Fluoxetine 25 mg-olanzapine 3 mg to fluoxetine 25 mg-olanzapine 6 mg orally once a day
Maintenance dose: Adjust with caution as clinically necessary to within a range of:

Maximum dose: Fluoxetine 50 mg-olanzapine 12 mg orally once a day
Duration: It is generally accepted that treatment-resistant depression and Bipolar I disorder, including the depressive episodes associated with Bipolar I disorder, are chronic illnesses requiring chronic treatment.

Comments:

Use: Acute treatment of treatment-resistant depression and depressive episodes associated with Bipolar I Disorder

Usual Geriatric Dose for Bipolar Disorder

Initial Dose: Fluoxetine 25 mg-olanzapine 3 mg to fluoxetine 25 mg-olanzapine 6 mg orally once a day
Maintenance dose: Adjust with caution as clinically necessary to within a range of:

Maximum dose: Fluoxetine 50 mg-olanzapine 12 mg orally once a day
Duration: It is generally accepted that treatment-resistant depression and Bipolar I disorder, including the depressive episodes associated with Bipolar I disorder, are chronic illnesses requiring chronic treatment.

Comments:

Use: Acute treatment of treatment-resistant depression and depressive episodes associated with Bipolar I Disorder

Usual Pediatric Dose for Depression

10 to 17 years of age:
Initial Dose: Fluoxetine 25 mg-olanzapine 3 mg orally once a day
Maintenance dose: Adjust as clinically necessary to within a range of:

Maximum dose: Fluoxetine 50 mg-olanzapine 12 mg orally per day
Duration: It is generally accepted that Bipolar I disorder, including the depressive episodes associated with Bipolar I disorder, is a chronic illness requiring chronic treatment.

Comment: The safety of doses above fluoxetine 50 mg and olanzapine 12 mg per day has not been evaluated in pediatric clinical studies

Use: Acute treatment of depressive episodes associated with Bipolar I Disorder

Usual Pediatric Dose for Bipolar Disorder

10 to 17 years of age:
Initial Dose: Fluoxetine 25 mg-olanzapine 3 mg orally once a day
Maintenance dose: Adjust as clinically necessary to within a range of:

Maximum dose: Fluoxetine 50 mg-olanzapine 12 mg orally per day
Duration: It is generally accepted that Bipolar I disorder, including the depressive episodes associated with Bipolar I disorder, is a chronic illness requiring chronic treatment.

Comment: The safety of doses above fluoxetine 50 mg and olanzapine 12 mg per day has not been evaluated in pediatric clinical studies

Use: Acute treatment of depressive episodes associated with Bipolar I Disorder

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Liver dysfunction:
Initial dose: Fluoxetine 25 mg-olanzapine 3 mg to fluoxetine 25 mg-olanzapine 6 mg orally once a day

Dose Adjustments

An initial dose of fluoxetine 25 mg-olanzapine 3 mg to fluoxetine 25 mg-olanzapine 6 mg orally once a day should be considered in patients:


Comments:

Switching from:
MAOI to fluoxetine-olanzapine therapy: At least 14 days should elapse
Fluoxetine-olanzapine to MAOI therapy: At least 5 weeks should elapse

Treatment withdrawal:

Precautions

US BOXED WARNINGS:
SUICIDAL THOUGHTS AND BEHAVIORS:


INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS:

Safety and efficacy have not been established in patients younger than 10 years for the treatment of Bipolar I depression.

Consult WARNINGS section for additional precautions.

Dialysis

Hemodialysis: No adjustment recommended
Peritoneal dialysis: Data not available

Other Comments

Administration advice:


General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.