Skip to Content

User Reviews for Effexor

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Filter by:

Effexor Rating Summary

User Ratings
10
   
16%(5)
9
   
13%(4)
8
   
16%(5)
7
   
10%(3)
6
   
7%(2)
5
   
10%(3)
4
   
4%(1)
3
   
4%(1)
2
   
7%(2)
1
   
22%(7)
5.8/10 Average Rating
33 Ratings with 35 User Reviews

What next? Compare all 61 medications used in the treatment of Major Depressive Disorder.

Reviews for Effexor to treat Major Depressive Disorder

Sort by:

"Horrible experience that I feel left me permanently damaged. Prescribed 37mg for panic disorder, social anxiety disorder, and major depressive disorder. Every symptom it was intended to treat got worse. I got so drowsy that I fell asleep through a 12 hour work shift as a caregiver, client had a fall and I did not wake up. I could not open my eyes no matter how badly I tried. Detoxing was worse. Unbearable body aches that made me more suicidal than I’d ever been because nothing relieved it. The brain zaps made me breakdown into a full panic attack crying every time because they were so painful and agitating. I’m 3 weeks off of it and having bizarre behaviors that I NEVER had before, even in my worst depression. I’ve had to give up my car keys from trying to drive off a cliff/into a wall suddenly with no warning and for no reason, I am unable to work because of my mental state that is NOT going back to baseline with time."

   
1.0

Jess (taken for 1 to 6 months) August 12, 2018

0 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"I was prescribed 37.5 mg of Effexor at the beginning then to 75 mg, then up to 150 mg. At that time I started having nausea. My dose was raised up to 225 mg, and there it got real bad. Strong nausea, vomit, brain zaps, anxiety so strong I could rip off my skin with my hands, stomach problems. I wasn't suicidal for a good time, until now. I thought my harsh past was the worst time of my life no. This so much worse. I was not able to see my psychiatrist so I had to deal with it alone, I lowered the dose, but I still had all these effects. Right now it's a day I'm off. I'm feeling brain zaps, fever feeling, can't do hard work, can't walk fast, difficulty eating and digesting, and anxiety. I've read some people responded well to this antidepressant, but if you are about to start taking this, don't. You either take it and it works OR it will bring you down, it's not worth it. Stay away from this, please."

   
1.0

anon23 (taken for 1 to 6 months) June 15, 2018

1 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"Within the first week of trying Effexor, I noticed it made me go to the bathroom excessively and I lost all of my sexual sensation. I did stay on it for another month+ to see if these symptoms would level out with time. They did not. So after 8 weeks, I am back to the drawing board to see if something else can work better."

   
3.0

Diane457 (taken for 1 to 6 months) April 24, 2018

1 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"I was 17 years old when I was put on effexor (a few years ago) after many medications weren't working for my major depressive disorder. First month it didn't feel like it was doing anything but I didn't think much about it, I think a lot of people aren't aware of how common this drug makes people actually try commit suicide. I was told by one of my friends to not start taking this medication because it is known to make people go over the edge but I didn't listen and in the end this medication made all my symptoms worse after being on it for 4 months. I felt VERY suicidal and felt as though I was living in a dream or in a trance. I did end up trying to commit suicide while being on this medication I suggest everyone to NOT start this medication."

   
1.0

Lilbaby March 4, 2018

0 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"I have fibromyalgia and the doctors also diagnosed major depressive disorder. After a few attempts, I was prescribed Effexor, but I was never warned of the side effects or the horrible withdrawal symptoms if you ever want to stop. Research it first, I wish I had. I could not get my prescription for 4 days once and I felt like a drug addict, throwing up, sweating, headache, chest pains. It was severe. I think dying would have been a welcome option at one point. All because I had not realized I was out of refills. Anything that severe is not safe for your body. Now, I am stuck on a medication that has made me feel worse until I can do slowly wean off that it may take a year plus because it impacts your entire body when you cut back slightly."

Purduegoddess (taken for 2 to 5 years) November 20, 2017

4 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"I have a significant loss of motivation but this is not new. Effexor has not helped this symptom."

Kjs1216 (taken for 6 months to 1 year) August 17, 2017

4 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"Makes me very fatigued. Almost zombie like. I have a hard time concentrating on anything. Hoping it just takes some time to get in my system and work correctly. If not, going to see if I can get in something different."

   
6.0

Anonymous (taken for 1 to 6 months) July 6, 2017

7 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"Effexor I have tried many drugs but found that "in my case" they are not necessary. I went for an ultrasound on my carotid vein. The doctors said the flow was in the normal range but you could see that they were narrow. I went out of country to have them widened... No more anxiety and depression....drugs are cheaper and more profitable than minor surgery. I will return for stents. "

   
8.0

Bunsdad (taken for 1 to 2 years) June 21, 2017

3 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"I've taken Duloxetine for years for major depression/osteoarthritis, but it never did much. My new psychologist wanted me to go off duloxetine and try a different A.D. **(Pro-tip - duloxetine can be titrated off of QUICKLY (within 2 weeks) if concurrent, temporary therapy of low-dose Prozac is performed at the same time. 10mg Prozac sufficient to prevent brain zaps and withdrawal syndrome from Duloxetine). I started with 75mg of Venlafaxine the first week. I didn't feel quite right, but not so bad that I felt I needed to report anything. After one week at 75mg per day, I began taking 150mg, a doubling. One day at 150mg was nearly the end of me. Immediately after it "hit" I became hostile, aggressive, suicidal, and unable to calm down."

   
1.0

Badkittym (taken for less than 1 month) May 12, 2017

9 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"Made me sick"

   
1.0

smiley2 (taken for less than 1 month) April 19, 2017

8 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"This drug seems to have helped. I've just gone up to 225mg. Profuse sweating and the rapid withdrawal are the worst."

   
5.0

MDewey (taken for 5 to 10 years) January 25, 2017

6 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"I have been on Effexor now for almost 6 months. I take a combined dose of 75mg and 150mg at once( 225mg) I started at 150 and was given the 75mg a few days later to help with my anxiety. The meds do make me " numb" to emotions, and it does help with my depression and anxiety. I have good and bad days. Sometimes my meds will make me sick to my stomach, I often feel dizzy and feel brain zaps, and " electrical" zaps down my arms and fingers. It often takes away my appetite, and have lost weight I often struggle with constapation too. And sometimes it makes the voices, depression and anxiety worse. Compared to other meds in the past, Effexor is better. On good days I feel better and turn from realistic view point in the world to a more positive"

   
6.0

Hannah626 (taken for 6 months to 1 year) November 27, 2016

15 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"HI , dz . I wanted to share my expirience with effexor ( flaxyne) for anxiety , panic attack disorder and depression I m a 28 old girl I have been taking effexor 75 mg for years but no result at all then my ps augmented the dose to 225mg which works greatly now with all my disorders and I m also on 100mg sulpiride which blocks perfectly black persecutive ideas and help reduce my anxiety too but here is the prblm I faced an important lack of libido and anorgasmia and a delayed period due to high dose flaxyne probably , but after months I m taking an infusion of Fenugreek seeds I m not drinking every day but at least twice in 28 days and it really helped with the side effects of effexor ."

   
7.0

Mjdalina (taken for 1 to 2 years) October 20, 2016

8 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"I had been off all meds for 10 yrs when I had a major relapse and knew it was time to medicate again. Effexor is hard to get on, lots of dizziness and exhaustion. Also if I am late taking it I feel awful. Headaches, anxiety, mood swings. Don't ever miss a dose!! I can't stress this enough. Withdrawal hits hard and fast, even within 12 hours. Sweats, chills, headache, dreams, whole body pain. HOWEVER it does help me get through the day. I have suicidal depression and clinical anxiety, so for me it is worth some struggle to stay with Effexor because it does give me relief. It calms my brain, allows me to get moving with my day, and not have the threat of my own self-destructive tendencies."

   
9.0

Anonymous (taken for 6 months to 1 year) October 7, 2016

23 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"On Pristique for two years with good results, then started getting really depressed. Doc prescribed 150 mg of Effexor for six weeks. I didn't feel any better and was having horrible nightmares and constipation. I was so disgusted so I weaned myself off over period of six weeks. I thought I was going insane, the nightmares increased and I was jumping out of bed during the night with leg cramps ,was nauseated and dizzy. When the dizziness got so bad that I fell down, I went to ER and they told me that was withdrawal symptoms and go back to doc. Now I am down to 37,5 mg a day. Nightmares not so severe but have terrible leg cramps. Hope to be off after one more week."

   
1.0

Anonymous September 19, 2016

11 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"I can't use the explicit language to describe my time with this, IMO, rat poison..Started at 37.5 ,then 75,eventually 225.Naturally, Dr's always say-"You've got to give it time to work!"..SURE DOC!..Want you to all know I'm no rookie at this, having battled depression for 23 years, and taken over 30 different meds, and certainly, THIS DRUG WAS BY FAR, THE WORSTTTTT..I refuse to believe that this drug was allowed to be given to humans.Getting on it, I became practically more dead, spending 20 hours a day in bed,, suicidal ideations one after another, crying, not eating, hopeless even more and every other negative symptom you can name associated with depression.Getting off is YOUR WORST NIGHTMARE-FOR ME?.3 ENTIRE MONTHS!=BEWARE!!"

   
1.0

hugoboy (taken for 1 to 6 months) August 5, 2016

24 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"I've been on antidepressants for 16 years. From Celexa, to Prozac, to Paxil with none ever truly taking away my depression and anxiety. I suffer from major depressive disorder, ptsd, anxiety and I'm bipolar as well. Since starting Effexor, my life has dramatically changed for the better. I'm honestly the happiest and calmest I've been since the age of 15. I started with 37.5mg 2x daily and I'm now up to max dosage. I've zero side effects and can function fully without benzodiazepines for my anxiety thanks to this medication. I HIGHLY recommend giving it a try, especially if no other antidepressants have truly made you feel 100%. It's possible to beat depression with the right medication, just keep on trying and hang in there!"

   
10

StacyAnna (taken for 1 to 2 years) July 9, 2016

40 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"It took 3 years to figure out that it was the Effexor that was causing my constipation. I was given MORE prescriptions to counter-act, but that just didn't work-actually moved me to beyond the other end of the spectrum. After forgetting a dose and experiencing the withdrawal symptoms, I immediately wanted to get off, but because I really didn't have any other options, I just continued on. I have tried many other different medications to help cope with depression and anxiety-Effexor seemed to work on the brain, but what it did to my guts is far worse. Multiple imaging, ER visits, unnecessary surgery and even a trip to the Mayo Clinic to figure out why I couldn't poop. To me, Effexor is POISON"

   
2.0

dgd84 May 5, 2016

15 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"I wish somebody had told me how addictive this drug is before I started taking it. Had I known how bad the withdrawal symptoms were, I probably would never have gone on it. (Although that might be a good thing, as I need(ed) to be on it.) It has definitely helped. The worst thing is HAVING to take it...literally. It's a full-out physical addiction. If we go somewhere and it doesn't get packed, I'm in trouble. It's NOT something to be taken for short-term or seasonally. Other than the withdrawals the main side effect is sweating. I shower every morning and by mid-afternoon I have to put Kleenexes or some sort of absorbing pad in my arm pits! In the past 17 years, I've also been on Paxil, Celexa, Prozac, Lexapro, and one other."

   
4.0

Depression for 17+ years February 22, 2016

24 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"I'm currently on venlafaxine, 300mg/day, and have been on it for 6 months now. This stuff works beautifully for me. I had/have MDD, GAD, SAD, and took Paxil for 10 years, which worked quite well until 8 months ago. I was scared of switching because of the fact that not all anti-depressants work for everyone, and I was terrified of fully reverting back to my suicidal, petrified old self. My psychiatrist was able to convince me after a couple months to go for it. On the venlafaxine I feel calm, HAPPY, able to concentrate, mildly euphoric, and better than I did in my early days of taking Paxil. This stuff is hit or miss for different people, but don't be scared to try it if you haven't. And give it time to work."

   
10

Mike001 (taken for 6 months to 1 year) December 10, 2015

49 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"I stopped taking this medicine briefly, for around 5 days, due to the "speed effect" and had to go right back on it, due to brain zaps!! I was (and still am) only taking 75 mg daily (once in the am). I take 1 mg of Xanax daily, but if I take it AFTER the Effexor, it won't work. I decided to switch it around and take it BEFORE the antidepressant and it works a LITTLE better, but not much. I used to take it early in the afternoon and was up all night. Now as long as I take it before 1 pm, I sleep fine. I've been taking it since January of 2014 and have noticed me being much calmer, still anxious at times, but much better before prescribed to me! It DOES cause, weight loss, drowsiness and fatigue if I take it while lying down."

   
5.0

Costillo December 7, 2015

14 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"Don't take it. Your emotions become dull and feel fake. Even your laughter feels fake. Your sleep becomes horrible. You overeat because you don't care anymore. The first week you feel like you're on meth. It feels great. Then it wears away and you become a dull and empty mess with memory problems and no motivation to do anything including getting off of the medicine. It's easier just to take it. I'm in my second week of withdrawal. I would just take 8-10 beads when I would get dizzy and it would go away. ez-pz. My depression did come back even worse. Maybe it's my minds way of telling me I'm not doing anything to make my life better. Maybe I should change my life instead of taking a pill, especially this pill."

   
2.0

AnotherDanApparently (taken for 6 months to 1 year) October 25, 2015

14 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"I took Effexor for many years. I believe I was becoming resistant to it because it wasn't addressing my depression anymore. I tapered off as slowly as possible and I can safely say it is the worst withdrawal I have ever had in my life. Nausea, dizziness, sickly feeling, huge brain zaps, lethargy, headaches. It was horrible. I am so glad to be off of it. My new medication, wellbutrin and lexapro are much better in controlling my chronic major depression. I will never be off drugs, but I would never take this drug again."

   
5.0

Tinteardrop (taken for 5 to 10 years) September 22, 2015

24 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"17 years ago I had a breakdown with anxiety and depression - tried aropax and it was hell on earth. Changed to efexor, it started working after 3 weeks. I've been on it for 17 years or so on various doses between 150 and 375 and it's been amazing. I worry about health side effects but it's been a life saver, no longer a wreck but can cope."

Meeee12345 September 19, 2015

34 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

"Increase dose more slowly than the doctor says. I was convinced I was actually in hell for a week after increasing my dose for one single day. It helps my situation, but it ruins my memory, kills motivation, kills desire or will to do anything. A cool and crisp morning loses that good feeling and your sleep sucks causing you to be tired all day. I would recommend to take a dose only on days you feel awful. Maybe 15mg. I regret taking this every day. The withdrawal is worse than alcohol, tobacco and other SSRIs combined."

   
8.0

DanMedicineReview August 19, 2015

20 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Page 1 2 Next

Learn more about Major Depressive Disorder

Micromedex® Care Notes

Symptoms and treatments

Hide