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Medications for Bipolar Disorder

The medications listed below are related to or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Lamictal 8.1 662 reviews for Lamictal to treat Bipolar Disorder Rx C N X
Generic name:
lamotrigine systemic
Drug class:
triazine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
lamotrigine 8.1 1081 reviews for lamotrigine to treat Bipolar Disorder Rx C N X
Generic name:
lamotrigine systemic
Brand names:
Lamictal, Lamictal ODT, Lamictal CD, Subvenite
Drug class:
triazine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Seroquel 6.8 407 reviews for Seroquel to treat Bipolar Disorder Rx C N X
Generic name:
quetiapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Vraylar 5.9 385 reviews for Vraylar to treat Bipolar Disorder Rx N X
Generic name:
cariprazine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Abilify 5.7 351 reviews for Abilify to treat Bipolar Disorder Rx C N X
Generic name:
aripiprazole systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
lithium 7.3 353 reviews for lithium to treat Bipolar Disorder Rx D N X
Generic name:
lithium systemic
Brand name:
Lithobid
Drug class:
antimanic agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Abilify Maintena 6.1 23 reviews for Abilify Maintena to treat Bipolar Disorder Rx C N X
Generic name:
aripiprazole systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Caplyta 7.0 123 reviews for Caplyta to treat Bipolar Disorder Rx N X
Generic name:
lumateperone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Latuda 6.3 668 reviews for Latuda to treat Bipolar Disorder Rx B N X
Generic name:
lurasidone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Lybalvi 8.2 12 reviews for Lybalvi to treat Bipolar Disorder Rx N X
Generic name:
olanzapine / samidorphan systemic
Drug class:
psychotherapeutic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Abilify Asimtufii 8.0 1 review for Abilify Asimtufii to treat Bipolar Disorder Rx C N X
Generic name:
aripiprazole systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
cariprazine 6.1 429 reviews for cariprazine to treat Bipolar Disorder Rx N X
Generic name:
cariprazine systemic
Brand name:
Vraylar
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
lumateperone 7.0 125 reviews for lumateperone to treat Bipolar Disorder Rx N X
Generic name:
lumateperone systemic
Brand name:
Caplyta
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
olanzapine / samidorphan 8.0 13 reviews for olanzapine / samidorphan to treat Bipolar Disorder Rx N X
Generic name:
olanzapine / samidorphan systemic
Brand name:
Lybalvi
Drug class:
psychotherapeutic combinations
For consumers:
dosage, interactions, side effects
Fanapt 5.5 2 reviews for Fanapt to treat Bipolar Disorder Rx C N X
Generic name:
iloperidone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
quetiapine 7.0 708 reviews for quetiapine to treat Bipolar Disorder Rx C N X
Generic name:
quetiapine systemic
Brand names:
Seroquel, Seroquel XR
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
gabapentin Off-label 8.5 144 reviews for gabapentin to treat Bipolar Disorder Rx C N X
Generic name:
gabapentin systemic
Drug class:
gamma-aminobutyric acid analogs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Depakote 6.2 189 reviews for Depakote to treat Bipolar Disorder Rx D N X
Generic name:
divalproex sodium systemic
Drug class:
fatty acid derivative anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
bupropion Off-label 7.2 90 reviews for bupropion to treat Bipolar Disorder Rx C N X
Generic name:
bupropion systemic
Drug class:
miscellaneous antidepressants, smoking cessation agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
clonazepam Off-label 8.8 97 reviews for clonazepam to treat Bipolar Disorder Rx D 4 X
Generic name:
clonazepam systemic
Drug class:
benzodiazepines, benzodiazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
divalproex sodium 6.5 278 reviews for divalproex sodium to treat Bipolar Disorder Rx D N X
Generic name:
divalproex sodium systemic
Brand names:
Depakote, Depakote ER
Drug class:
fatty acid derivative anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
oxcarbazepine Off-label 8.2 169 reviews for oxcarbazepine to treat Bipolar Disorder Rx C N X
Generic name:
oxcarbazepine systemic
Drug class:
dibenzazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Seroquel XR 7.3 112 reviews for Seroquel XR to treat Bipolar Disorder Rx C N X
Generic name:
quetiapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
aripiprazole 5.7 445 reviews for aripiprazole to treat Bipolar Disorder Rx C N X
Generic name:
aripiprazole systemic
Brand names:
Abilify, Abilify Maintena, Abilify Asimtufii, Abilify MyCite
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
sertraline Off-label 6.8 54 reviews for sertraline to treat Bipolar Disorder Rx C N X
Generic name:
sertraline systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Risperdal 6.3 89 reviews for Risperdal to treat Bipolar Disorder Rx C N X
Generic name:
risperidone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Geodon 5.6 241 reviews for Geodon to treat Bipolar Disorder Rx C N X
Generic name:
ziprasidone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
risperidone 6.1 183 reviews for risperidone to treat Bipolar Disorder Rx C N X
Generic name:
risperidone systemic
Brand names:
Risperdal, Risperdal Consta, Rykindo
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
topiramate Off-label 7.1 132 reviews for topiramate to treat Bipolar Disorder Rx D N X
Generic name:
topiramate systemic
Drug class:
carbonic anhydrase inhibitor anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Zyprexa 6.3 172 reviews for Zyprexa to treat Bipolar Disorder Rx C N X
Generic name:
olanzapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
olanzapine 6.4 322 reviews for olanzapine to treat Bipolar Disorder Rx C N X
Generic name:
olanzapine systemic
Brand name:
Zyprexa
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
venlafaxine Off-label 6.7 77 reviews for venlafaxine to treat Bipolar Disorder Rx C N X
Generic name:
venlafaxine systemic
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Depakote ER 7.4 49 reviews for Depakote ER to treat Bipolar Disorder Rx D N X
Generic name:
divalproex sodium systemic
Drug class:
fatty acid derivative anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
duloxetine Off-label 6.8 51 reviews for duloxetine to treat Bipolar Disorder Rx C N X
Generic name:
duloxetine systemic
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
citalopram Off-label 8.5 14 reviews for citalopram to treat Bipolar Disorder Rx C N X
Generic name:
citalopram systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
escitalopram Off-label 6.4 61 reviews for escitalopram to treat Bipolar Disorder Rx C N X
Generic name:
escitalopram systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Saphris 7.3 231 reviews for Saphris to treat Bipolar Disorder Rx C N X
Generic name:
asenapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
carbamazepine 7.1 109 reviews for carbamazepine to treat Bipolar Disorder Rx D N X
Generic name:
carbamazepine systemic
Brand name:
Equetro
Drug class:
dibenzazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
ziprasidone 5.8 299 reviews for ziprasidone to treat Bipolar Disorder Rx C N X
Generic name:
ziprasidone systemic
Brand name:
Geodon
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
clonidine Off-label 7.3 9 reviews for clonidine to treat Bipolar Disorder Rx C N X
Generic name:
clonidine systemic
Drug class:
antiadrenergic agents, centrally acting
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
lurasidone 6.3 720 reviews for lurasidone to treat Bipolar Disorder Rx B N X
Generic name:
lurasidone systemic
Brand name:
Latuda
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Lamictal ODT 9.0 3 reviews for Lamictal ODT to treat Bipolar Disorder Rx C N X
Generic name:
lamotrigine systemic
Drug class:
triazine anticonvulsants
For consumers:
dosage, interactions, side effects
armodafinil Off-label 9.3 15 reviews for armodafinil to treat Bipolar Disorder Rx C 4
Generic name:
armodafinil systemic
Drug class:
CNS stimulants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Symbyax 7.7 38 reviews for Symbyax to treat Bipolar Disorder Rx C N X
Generic name:
fluoxetine / olanzapine systemic
Drug class:
psychotherapeutic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
valproic acid 5.8 28 reviews for valproic acid to treat Bipolar Disorder Rx D N X
Generic name:
valproic acid systemic
Drug class:
fatty acid derivative anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
asenapine 7.2 252 reviews for asenapine to treat Bipolar Disorder Rx C N X
Generic name:
asenapine systemic
Brand name:
Saphris
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
desvenlafaxine Off-label 7.2 21 reviews for desvenlafaxine to treat Bipolar Disorder Rx C N X
Generic name:
desvenlafaxine systemic
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
fluoxetine / olanzapine 7.5 48 reviews for fluoxetine / olanzapine to treat Bipolar Disorder Rx C N X
Generic name:
fluoxetine / olanzapine systemic
Brand name:
Symbyax
Drug class:
psychotherapeutic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Lamictal CD 2.0 1 review for Lamictal CD to treat Bipolar Disorder Rx C N X
Generic name:
lamotrigine systemic
Drug class:
triazine anticonvulsants
For consumers:
dosage, interactions, side effects
levetiracetam Off-label 6.6 8 reviews for levetiracetam to treat Bipolar Disorder Rx C N X
Generic name:
levetiracetam systemic
Drug class:
pyrrolidine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Lithobid 6.7 15 reviews for Lithobid to treat Bipolar Disorder Rx D N X
Generic name:
lithium systemic
Drug class:
antimanic agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
tiagabine Off-label 10 3 reviews for tiagabine to treat Bipolar Disorder Rx C N X
Generic name:
tiagabine systemic
Drug class:
gamma-aminobutyric acid reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Abilify MyCite Rate Add review Rx C N X
Generic name:
aripiprazole systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Equetro 6.0 5 reviews for Equetro to treat Bipolar Disorder Rx D N X
Generic name:
carbamazepine systemic
Drug class:
dibenzazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
iloperidone 8.9 12 reviews for iloperidone to treat Bipolar Disorder Rx C N X
Generic name:
iloperidone systemic
Brand name:
Fanapt
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
paliperidone Off-label 4.8 58 reviews for paliperidone to treat Bipolar Disorder Rx C N X
Generic name:
paliperidone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
perphenazine Off-label 7.2 13 reviews for perphenazine to treat Bipolar Disorder Rx N N X
Generic name:
perphenazine systemic
Drug class:
phenothiazine antiemetics, phenothiazine antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Risperdal Consta 2.5 4 reviews for Risperdal Consta to treat Bipolar Disorder Rx C N X
Generic name:
risperidone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Subvenite Rate Add review Rx C N X
Generic name:
lamotrigine systemic
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Rykindo Rate Add review Rx C N X
Generic name:
risperidone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
verapamil Off-label 8.0 1 review for verapamil to treat Bipolar Disorder Rx C N X
Generic name:
verapamil systemic
Drug class:
calcium channel blockers, group IV antiarrhythmics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes

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Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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