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Generic Name: lurasidone (loo RAS i done)
Brand Names: Latuda

What is Latuda?

Latuda (lurasidone) is an antipsychotic medicine. It works by changing the effects of chemicals in the brain.

Latuda is used to treat schizophrenia in adults and teenagers who are at least 13 years old.

Latuda is also used to treat episodes of depression in adults with bipolar disorder (manic depression).

Important information

Latuda is not approved for use in psychotic conditions related to dementia. Lurasidone may increase the risk of death in older adults with dementia-related conditions.

Some young people have thoughts about suicide when first taking medicine to treat depression. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Before you take Latuda, tell your doctor if you have liver disease, kidney disease, heart disease, high blood pressure, heart rhythm problems, a history of heart attack or stroke, high cholesterol or triglycerides, low white blood cell (WBC) counts, seizures, diabetes, Parkinson's disease, trouble swallowing, or a history of breast cancer or suicidal thoughts.

Some medicines can interact with lurasidone and should not be used at the same time. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.

While you are taking Latuda, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking this medicine.

Latuda may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Drinking alcohol can increase certain side effects of lurasidone. Stop using this medicine and call your doctor at once if you have very stiff (rigid) muscles, high fever, sweating, confusion, fast or pounding heartbeats, feeling like you might pass out, tremors, or twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs.

Before taking this medicine

You should not use Latuda if you are allergic to lurasidone.

Some medicines can interact with lurasidone and should not be used at the same time. Your doctor may need to change your treatment plan if you use certain other medicines, including:

  • antifungal medicine such as ketoconazole or voriconazole;

  • an antibiotic such as clarithromycin or rifampin;

  • an antiviral such as ritonavir;

  • St. John's wort; or

  • seizure medicine such as carbamazepine or phenytoin.

Latuda is not approved for use in psychotic conditions related to dementia. Latuda may increase the risk of death in older adults with dementia-related conditions.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • heart disease, high blood pressure;

  • high cholesterol or triglycerides (a type of fat in the blood);

  • seizures or epilepsy;

  • liver or kidney disease;

  • low white blood cell (WBC) counts;

  • diabetes, or a family history of diabetes;

  • abnormal hormone function tests (thyroid, pituitary gland);

  • breast cancer;

  • depression or bipolar disease (unless you are taking Latuda to treat depressive episodes);

  • suicidal thoughts or actions; or

  • a stroke.

Some young people have thoughts about suicide when first taking medicine to treat depression. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Latuda, do not stop taking it without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of lurasidone on the baby.

It is not known whether lurasidone passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding.

Latuda is not approved for schizophrenia in anyone younger than 13 years old. Latuda is not approved for depression in anyone younger than 18 years old.

How should I take Latuda?

Take Latuda exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Latuda should be taken with food (at least 350 calories).

While using Latuda, you may need frequent blood tests.

It may take several weeks before your symptoms improve. Keep using the medication as directed. Call your doctor if your symptoms do not improve, or if they get worse while using Latuda.

You should not stop using Latuda suddenly. Stopping suddenly may cause other problems.

Store at room temperature away from moisture and heat.

Latuda dosing information

Usual Adult Dose for Schizophrenia:

Initial dose: 40 mg orally once a day
Maintenance dose: 40 to 160 mg orally per day
Maximum dose: 160 mg per day

Comments:
-Initial dose titration is not needed.
-This drug should be taken with food (at least 350 calories); drug exposure is expected to be significantly lower if not taken with food.

Use: For the treatment of schizophrenia.

Usual Adult Dose for Bipolar Disorder:

Initial dose: 20 mg orally once a day
Maintenance dose: 20 mg to 120 mg orally once a day
Maximum dose: 120 mg per day

Comments:
-Initial dose titration is not needed; this drug should be taken with food (at least 350 calories) drug exposure is expected to be significantly lower if not taken with food.
-Initial and maintenance doses are the same for monotherapy and for adjunctive therapy; in monotherapy studies, efficacy in the lower dose range of 20 to 60 mg per day was, on average, comparable to higher doses of 80 mg to 120 mg.
-The efficacy in the treatment of mania has not been established.

Uses:
-As monotherapy or adjunctive therapy with either lithium or valproate for the treatment of major depressive disorder associated with bipolar disorder (bipolar depression).

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Latuda?

It is easier to become dangerously overheated and dehydrated while you are taking Latuda. Drink plenty of fluids, especially in hot weather and during exercise. You may also be more sensitive to temperature extremes (hot or cold).

Grapefruit and grapefruit juice may interact with lurasidone and lead to unwanted side effects. Avoid the use of grapefruit products while taking Latuda.

Latuda may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol. Dangerous side effects could occur.

Latuda side effects

Get emergency medical help if you have signs of an allergic reaction to Latuda: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

High doses or long-term use of Latuda can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. The longer you take this medicine, the more likely you are to develop a serious movement disorder. The risk of this side effect is higher in women and older adults.

Call your doctor at once if you have:

  • irregular menstrual periods, breast or vaginal changes, nipple discharge;

  • dizziness, fainting, fast or slow heartbeats;

  • trouble swallowing;

  • seizure (convulsions);

  • blood cell disorders - sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, swollen gums, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;

  • high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss; or

  • severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common Latuda side effects may include:

  • weight gain;

  • drowsiness;

  • nausea, vomiting;

  • feeling restless or being unable to sit still; or

  • tremors, muscle stiffness, problems with muscle movement.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Latuda?

Taking Latuda with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Many drugs can interact with lurasidone. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially medicines to treat:

  • depression or psychotic episodes;

  • sleep problems (insomnia);

  • high blood pressure or a heart rhythm disorder;

  • swelling or inflammation;

  • seizures; or

  • Parkinson's disease.

This list is not complete and many other drugs can interact with lurasidone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

  • Your pharmacist can provide more information about Latuda.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Latuda only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Cerner Multum, Inc. Version: 5.03.

Date modified: March 02, 2017
Last reviewed: February 13, 2017

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