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Armodafinil Side Effects

Medically reviewed by Last updated on Jan 15, 2024.

Applies to armodafinil: oral tablet.

Serious side effects of Armodafinil

Along with its needed effects, armodafinil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking armodafinil:

Less common

Get emergency help immediately if any of the following symptoms of overdose occur while taking armodafinil:

Symptoms of overdose

Other side effects of Armodafinil

Some side effects of armodafinil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to armodafinil: oral tablet.


The following reactions occurred more frequently with the 250 mg/day dose compared to the 150 mg/day dose: headache, rash, depression, dry mouth, insomnia, nausea.[Ref]


Common (1% to 10%): Rash, contact dermatitis, hyperhidrosis

Frequency not reported: Serious skin reactions including Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrosis (TEN)

Postmarketing reports: Skin and mouth sores, blistering, ulceration, Drug Reaction with Eosinophilia and System Symptoms

(DRESS)/Multiorgan Hypersensitivity[Ref]

Serious rash requiring hospitalization and discontinuation of treatment has been reported in association with the use of armodafinil or modafinil (the racemic mixture of S- and R-enantiomers). Rare cases of serious or life-threatening rash, including SJS and TEN, have been reported in adults and children in worldwide post-marketing experience with

modafinil and armodafinil.[Ref]


Common (1% to 10%): Seasonal allergy

Frequency not reported: Angioedema, anaphylaxis[Ref]


Common (1% to 10%): Insomnia, anxiety, depression, agitation, depressed mood, disturbance in attention, nervousness

Frequency not reported: Irritability, suicidal ideation

Postmarketing reports: Mania, delusions, hallucinations, aggression[Ref]


Common (1% to 10%): Palpitations, increased heart rate, increased blood pressure[Ref]


Frequency not reported: Angioedema, hypersensitivity (rash, dysphagia, and bronchospasm)


Common (1% to 10%): Nausea, diarrhea, dry mouth, dyspepsia, upper abdominal pain, constipation, vomiting, loose stools

Postmarketing reports: Mouth sores (including mouth blistering and ulceration)[Ref]


Common (1% to 10%): Polyuria[Ref]


Frequency not reported: Pancytopenia[Ref]


Common (1% to 10%): Increased gamma-glutamyltransferase, increased alkaline phosphatase

Rare (less than 0.1%): Elevated AST and/or ALT[Ref]


Common (1% to 10%): Anorexia, decreased appetite,

Frequency not reported: Decreased serum uric acid[Ref]

Nervous system

Very common (10% or more): Headache (17%)

Common (1% to 10%): Dizziness, paresthesia, tremor, migraine[Ref]


Common (1% to 10%): Fatigue, influenza-like illness, pain, pyrexia, thirst[Ref]


Common (1% to 10%): Dyspnea[Ref]


1. (2007) "Product Information. Nuvigil (armodafinil)." Cephalon Inc

2. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.