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Armodafinil Dosage

Applies to the following strength(s): 50 mg150 mg250 mg200 mg

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Narcolepsy

150 to 250 mg orally once a day in the morning

Comments:
-In obstructive sleep apnea (OSA), doses up to 250 mg/day have been well-tolerated but there is no consistent evidence of additional benefit beyond the 150 mg/day dose.
-In OSA, this drug is not a treatment for the underlying obstruction.
-In cases where continuous positive airway pressure (CPAP) is the treatment of choice for excessive sleepiness, a maximal effort to treat with CPAP for an adequate period of time should be made prior to initiating this drug.

Use: Treatment to improve wakefulness in patients with excessive sleepiness associated with OSA and narcolepsy.

Usual Adult Dose for Obstructive Sleep Apnea/Hypopnea Syndrome

150 to 250 mg orally once a day in the morning

Comments:
-In obstructive sleep apnea (OSA), doses up to 250 mg/day have been well-tolerated but there is no consistent evidence of additional benefit beyond the 150 mg/day dose.
-In OSA, this drug is not a treatment for the underlying obstruction.
-In cases where continuous positive airway pressure (CPAP) is the treatment of choice for excessive sleepiness, a maximal effort to treat with CPAP for an adequate period of time should be made prior to initiating this drug.

Use: Treatment to improve wakefulness in patients with excessive sleepiness associated with OSA and narcolepsy.

Usual Adult Dose for Shift Work Sleep Disorder

150 mg orally once a day approximately 1 hour prior to the start of the work shift

Use: Treatment to improve wakefulness in patients with excessive sleepiness associated with shift work disorder.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

-Mild to moderate hepatic impairment: Data not available.
-Severe hepatic impairment: A reduced dose is recommended; however, no specific guidelines have been suggested in the manufacturer product information. Use with caution.

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV

Dialysis

Data not available

Other Comments

Administration Advice:
-This drug can be taken with or without food.

General:
-Following is data about modafinil that may apply to this drug since they have similar pharmacologic properties: Although wake-promoting actions of modafinil are akin to sympathomimetic agents including amphetamine and methylphenidate, the effects of modafinil are dissimilar to amphetamine in that its effects are not antagonized by the dopamine receptor antagonist haloperidol and the locomotor activity it induces are not blocked by the dopamine synthesis inhibitor alpha-methyl-p-tyrosine.
-Modafinil-induced wakefulness can be attenuated by the alpha1-adrenergic receptor antagonist prazosin; however, modafinil is inactive in other in-vitro assay systems known to be responsive to alpha-adrenergic agonists such as the rat vas deferens preparation.

Monitoring:
-Cardiovascular: Heart rate, blood pressure
-General: Degree of sleepiness/drowsiness; signs of misuse or abuse

Patient Advice:
-Talk to your healthcare provider about alternative birth control options if you use a hormonal birth control method such as birth control pills, shots, implants, patches, vaginal rings, and intrauterine devices (IUDs). Women who use hormonal birth control methods may have a higher chance of getting pregnant while taking this drug and for 1 month after stopping treatment.
-If you become pregnant during treatment, talk to your healthcare provider about the pregnancy registry for this drug.
-Avoid driving and doing activities such as operating machinery while taking this drug until your degree of sleepiness/wakefulness has been assessed by your healthcare provider.
-Avoid drinking alcohol while taking this drug.
-This drug may help with sleepiness, but it is not a replacement for getting enough sleep.
-Stop taking this drug and contact your healthcare provider right away if you experience a rash or any allergic reaction, depression, anxiety, or signs of psychosis or mania.
-This drug has the potential to be abused and cause dependence; tell your healthcare provider if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

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