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User Reviews for Divalproex sodium

Also known as: Depakote, Depakote ER, Depakote Sprinkles

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. Learn more about Divalproex sodium.

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Divalproex sodium Rating Summary

User Ratings
10
   
22%(43)
9
   
10%(19)
8
   
18%(36)
7
   
15%(29)
6
   
4%(7)
5
   
5%(10)
4
   
5%(9)
3
   
10%(19)
2
   
4%(7)
1
   
13%(25)
6.5/10 Average Rating
204 Ratings with 175 User Reviews

What next? Compare all 80 medications used in the treatment of Bipolar Disorder.

Reviews for Divalproex sodium to treat Bipolar Disorder

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Depakote (divalproex sodium): "I was diagnosed with depression and anxiety 35 years ago, but finally received a diagnosis on the bipolar spectrum two years ago at the age of 60. Depakote ER (2000mg at night) fixed things I didn't know were wrong and has stilled the ultradian cycling that was really my problem all along. I feel luck that the only side effects I have encountered are hair loss at first (now resolved) and occasional heartburn. It relieved most of my depressive and hypomanic symptoms within three weeks, but I just added Lamictal to help a little more with depressive symptoms. I take a complicated stack of meds to manage psych. symptoms, but Depakote is by far the most important."

   
10

sf100 (taken for 2 to 5 years) February 7, 2018

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Depakote (divalproex sodium): "I have been diagnosed as bipolar for 20 years now and just a month ago listed as bipolar 1 severe with mixed moods. This is the only medication that REALLY works to help control my manic moods. ONLY side effect for me is a little bit of shaky hands after taking for a few hours."

   
8.0

Ash11485 January 26, 2018

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Depakote (divalproex sodium): "I have been taking depakote @ 1000mg for the past year and a half. I also take risperdol @ 1mg and just added on zoloft @ 100mg as well. The only positive thing this medicine has done for me is rid me of mania. I am constantly depressed and have persistent suicidal/negative thoughts. I feel like I have been sleep walking through my life since I have been put on this medication. Also I have gained 50 pounds and am so hungry all the time. I also have zero libido. When I say zero I mean zero. I have had sex on this medication and it was the most unenjoyable experience ever. Just nothing. Next time I go to see my physiatrist I am going to ask to switch medications. This might work for some but it has not worked for me in the slightest."

   
1.0

teelar (taken for 1 to 2 years) January 20, 2018

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Depakote (divalproex sodium): "Start a few days ago this medicine. So far I'm ok, no side effect. I can sleep all night and wake up rested. All my body pain is almost gone. Calmed my mania and anxiety. Been on Lithium before but was awful with the side effect and the worry to hurt my kidneys. Hoping this medicine works for me."

   
9.0

Liz2018 (taken for less than 1 month) January 19, 2018

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Depakote (divalproex sodium): "I've taken depakote for 13 years along with citalapram. 250 mg depakote with 10 mg of citalapram. It helped with my intense excitability, my severe depression and suicidal thoughts which happened to me 2 weeks out of the month. It was so bad. After taking these meds I felt so much better like a "normal" person. I had no side effects. My symptoms were down to 3 days instead of 3 weeks which I could deal with and didn't want to kill myself anymore. I'm an bipolar and/or pmdd. They are not working for me anymore so I'm going to have to change to something else. Hope this helps someone. :)"

   
10

Yellehs (taken for 10 years or more) January 7, 2018

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Depakote ER (divalproex sodium): "I have been on generic Depakote for 12 years. Prior to it, I took lithium for 28 years. On Depakote, I lost 30 pounds; and did not have hair loss. I do get tired in the afternoon and take a nap. I feel the medication helps me live a good life. I believe I would be dead without medication that keeps me from being manic."

   
9.0

Madoline December 4, 2017

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Depakote ER (divalproex sodium): "I'm going to say this. This medication has been a lifesaver for me. I've been on it for six months now. I take it for migraines, bipolar, and seizures. No noticeable side effects except for a lot of ear popping. I am a lot calmer than what I used to be. My anxiety is still there but it isn't as bad as it was. I can actually function on this medication. My family can be around me now. I used to rapid cycle and have mixed episodes at least ten times a week. Now they're gone. It's nice to be normal for a change. No grandiose delusions. No audible delusions. I am a little bit sleepier than normal. But with a change of diet, I'm okay. No hair falling out. Just the normal hair loss when it comes to the change of weather."

   
10

J2 Gal December 1, 2017

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Depakote (divalproex sodium): "Hi I've recently got married to my partner of 6 yrs, last year he was diagnosed with bipolar he has tried all different kinds of medicine but he’s started a new one call Depakote 5-10-17 for the last 2 weeks he’s had 2 personalities Mr Nice and Mr Horrible it can changed within mins do you think I should contact his doctor or bear with it. He’s never been like this I can’t talk to him, I can’t even look at him without him asking me what my problem is. This is really out of character. He is normal downer I know when they are coming and I can take time out and after 3-4 he’s back to him normal happy self but this I not sure how much more I can cope with!! We have a 5 yr old who keeps saying will daddy get better! I’m just in desperate need for some."

Life15hard (taken for less than 1 month) October 14, 2017

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Depakote ER (divalproex sodium): "I take non generic Depakote ER 1750 mg?? Haldol 4 mg, and propranolol 20 mg. I have some hair loss, insomnia, and shakiness. I believe the medicine is finally working after 17 years of trying every bipolar medication with Depakote ER. I lose my patience and get angry at customer service representatives sometimes. I lose my patience and get mildly angry at my husband but it appears to be under control. The insomnia at times gets really bad and I wind up calling lifenet to cope. I will be trying melatonin 3mg to see if this helps. I want to try 1500 mg of Depakote ER to see if my insomnia improves also."

   
7.0

chew chew (taken for 10 years or more) October 14, 2017

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Depakote (divalproex sodium): "It made my bi polar disorder worse, I had bad ringing in my ears also my heart rate increased. But it wasn't worse then when my hallucinations got so much worse then they already are."

   
9.0

Babi Girl95 October 2, 2017

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"Was prescribed for moderate to severe depression and anxiety. Was never put on mood stabilizers before was never diagnosed or had bipolar or manic disorders. It was a new doc so I thought it was a new approach and went along with it. After lithium threw me deeper into my depression my doc tried the depakote. It definitely helped bring me out of my lithium fog but after 4 to 6 months I gained 10 lb and found myself in and out of depression. I ultimately had to leave this doc as he didn't want to try anything else and recommended ECT! That was hard to hear and he was completely blowing me off. I also had tried to reach out to my therapist someone I was seeing 2x a week for 8 months and she never got back to me. I'm now on an antidepressant and waiting..."

   
2.0

Jilld1314 (taken for 1 to 6 months) October 1, 2017

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"I can't rate it yet but I gave it a 5 because it's been about 5 days. I've noticed a calm relax feeling. Normally after I exercise, I still have energy. Since I've started to take it, I've noticed a good calm relax tired feeling. Not a drowsy tired, which is good. Also, I'm noticing an attitude switch for the good. As for weight gain, nothing yet and I hope it stays that way. I'm eating much better and exercising more to balance just in case. I definitely feel a change for the good. Hopefully this is a fix until I can do it off medicine. If not, it is what it is. I'll keep an open mind. Let me know if anyone has anything different."

   
5.0

Joseph Robinson Jr September 18, 2017

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Depakote (divalproex sodium): "Love this medication, after 2-3 years of severe long lasting manic episodes finally decided to take meds full time. Hardly any side effects, very hungry, simply eat normally and you wont put weight on, the medication doesn't make you fat, eating does. Occasionally very tired and my stomach from time to time gets a little funny, just take with lots of water and food. Very calm, can concentrate, no racing thoughts, level, basically gave me my life back, works well at 750 even though I'm 80kgs, Dr upped me to 1000mg but felt too sedated so dropped back down. I move to 1000mg if I feel like I'm starting to drift a little for a few weeks then move back. However, this is the 7th med I have tried, all others have failed, never write one med off"

   
9.0

qwertyazsxdc (taken for 5 to 10 years) August 26, 2017

13 users found this comment helpful.
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Depakote ER (divalproex sodium): "I started Depakote ER 2000mg at bedtime about a year ago after decades of ineffective treatment for depression and anxiety. Depakote proved that I was misdiagnosed: it quickly alleviated my psych. symptoms and allowed me to reduce Xanax XR dose by half and eliminate PRN Xanax. I haven't experienced the weight loss side effect, but did lose a lot of hair at first. The hair seems to be thickening up now. I would give it 10 stars except for the hair loss."

   
9.0

LAGuy (taken for 1 to 2 years) August 14, 2017

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"So weird everyone complains of weight gain. This drug (divaproex sodium) makes me lose weight to the point it's actually a bit alarming. Appetite completely gone. I've stopped and started 3-5 times as I never take anything more than a year without stopping. Every time I take it like this week for example I started at 151 pounds 5"7 female. I don't work out or exercise ever and have dropped 12 pounds in 3 days. It actually usually gets so bad I have to go talk to my doctor about my weight loss. I can stomach food but it comes out in liquid form within 15 mins and clears my system. This drug is a major weight loss drug from me. I know everytime I start it it's a given I will be losing 10 pounds minimum. Good for mood."

Anonymous (taken for less than 1 month) May 19, 2017

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"After two valiant attempts to get past the adverse effects, I'm finished with Depakote. The first attempt lasted a week; as it can exaggerate the effects of other meds, I became so drowsy I couldn't drive. For the second attempt, it wasn't combined with any other medication and lasted 3 weeks. I felt continually agitated and anxious, began to quickly gain weight, had terrible gas and was going to the bathroom 4-5 times a day. Additionally, my hair began to fall out so quickly, even my husband noticed (and he's NOT very observant!). The most disturbing symptom was the frequent presence of pronounced, irregular heart beats and at least one near-syncopal episode. All this in just 21 days- thanks but no thanks!"

   
2.0

Undun (taken for less than 1 month) May 12, 2017

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Depakote (divalproex sodium): "Best med I've been on for Bipolar I. After 10 years on Lamictal as monotherapy, with continued mania and depression. I was hospitalized and switched to Depakote. I'm sad my doctors didn't try getting rid of the Lamictal sooner. I take 500mg (delayed-release) twice a day and, along with 80mg of Latuda, I haven't felt this stable or anxiety-free since I can remember. I'm not dulled out, back to my normal, serene self. Depakote is known to work wonders for mania, and I can attest to this effect being noticeable right away. I have gained a few pounds but I'm too happy with how calm, collected, and lucid I feel to think about letting Depakote go. No other side effects, and I don't find it highly sedating -- guess I'm one of the lucky ones."

   
10

FuckLamictal (taken for 1 to 6 months) April 15, 2017

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Depakote (divalproex sodium): "Depakote was a nightmare. Besides having acute, non-stop stomach pain with chronic diahrrea, my hair started falling out in clumps. Good thing I have thick hair or I could have been bald at the end of this drug. I don't recommend this to anyone. It was like taking poison."

   
1.0

Velveteen Rabbit (taken for 1 to 6 months) March 1, 2017

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"Only my depressions cause me problems, for which Epival (Divalproex Sodium) was entirely useless, even after a few months. Lithium and especially Lamotrigine proved much better options for me."

   
1.0

Canada345 (taken for 1 to 6 months) February 19, 2017

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"I have struggled silently with impulses to self-destruct/self-injure for many years. Various things would trigger episodes, frustrating conversations. Some temptations were very strong, and sometimes I quickly self-injured. I let people think I was suicidal, and therapists were geared to interpret that way, but it wasn't that; it was overwhelming impulses to hurt myself, which I couldn't explain and felt humiliated about. Then I got to a very good psychiatrist, who put me on Divalproex extended-release pills, which I take at night. While I am groggy in the morning, and feel tired in the afternoon, and sometimes require a nap. Recently, I've been triggered, but the impulse to hurt myself was much less. The drug was to slow things down."

   
8.0

Secret struggler February 19, 2017

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"The generic Depakote immediately and effectively controlled my mania, and smoothed out my moods. In combination, I take two anti-depressants, Wellbutrin and Lexapro (both generic). This 3-prong regimen is very effective for me in controlling my bipolar disporder."

   
9.0

Tektonik66 (taken for 1 to 2 years) January 18, 2017

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"I just took my first dose & am hopeful yet apprehensive. Hoping to see what others are experiencing."

   
6.0

Neu (taken for less than 1 month) January 12, 2017

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Depakote (divalproex sodium): "I have been through so many medications it's ridiculous... most of them didn't work AND caused severe side effects. The last one I was on before Depakote was lamotrigine (which really is better for bipolar II, from what I understand). I tend to run very manic (and don't have a thyroid anymore - cancer), so my doc and I decided this would probably be my best option. None of the new drugs worked on me. Depakote has been amazing. I can think a lot more clearly and I'm still me - just a lot more toned down. I've had no negative side effects except a slight tremor, but I'm also on xanax for severe anxiety, so its only noticeable when it's time for that. No weight gain, either. In fact, my appetite decreased. I haven't gained or lost, really."

   
10

espresso_dreams (taken for 1 to 2 years) December 27, 2016

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"It has worked well for me I was taking I can't even remember what that made me sleepy all the time and I did feel like a zombie. My doctor kept Zolof 100mg along with Depakote 500mg due to my panic attacks. After about a year we tried taking Zolof off but Depakote alone did not work for me. The combination did help my life a lot, more focused, I feel like I can organize my thoughts, get things done, follow through on plans... it changed my life for the better. The constant hunger and putting on weigh are a sadly too true for me, but given the improvement in the quality of life it gave me I find it a small price to pay. Also now that I am more focused I find it easier to actually get to the gym to work on loosing those 14 pounds."

   
8.0

hypomania (taken for 1 to 2 years) December 21, 2016

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Depakote (divalproex sodium): "Didn't realize how great it was till it was gone. After 4 years of failed cocktails until I found Depekote with Zoloft. I was on it for 3-5 months @1250mg and had Excessive Weight gain, insatiable hunger,,,BUT Worth it! I was productive, positive, stabilzed, making plans and following thru. Then Liver enzymes high @ 6 mo. and abruptly taken off ... Horrible move by panicked Doctor. On my third medicine since and all bad results. Any opinions on Depokote retry while protecting my liver with Milk Thistle & Turmeric? My last blood work was best its ever been. I have no faith in my Dr and am seeking a new."

   
8.0

Karyn 44ys Single Female (taken for 1 to 6 months) December 9, 2016

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