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Divalproex sodium Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Divalproex sodium Vraylar Lamictal
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Divalproex sodium Vraylar (cariprazine) Lamictal (lamotrigine)
Prescription only

Divalproex may be used for the treatment of absence or partial seizures, as a preventive treatment for migraines, and to treat mania associated with bipolar disorder. Divalproex may adversely and... View more

Prescription only

Vraylar is an atypical antipsychotic that is effective for the treatment of schizophrenia and bipolar disorder. Vraylar is usually well-tolerated and less likely than some other antipsychotics to... View more

Prescription only

Lamictal is used to decrease the frequency and severity of seizures in some types of epilepsy and also to stabilize mood in bipolar disorder. Rarely, Lamictal may cause a potentially fatal rash... View more

More about Divalproex sodium More about Vraylar (cariprazine) More about Lamictal (lamotrigine)
Ratings & Reviews

Divalproex sodium has an average rating of 6.6 out of 10 from a total of 503 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 24% reported a negative effect.

Vraylar has an average rating of 5.9 out of 10 from a total of 490 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 35% reported a negative effect.

Lamictal has an average rating of 8.0 out of 10 from a total of 783 ratings on Drugs.com. 76% of reviewers reported a positive effect, while 13% reported a negative effect.

View all 503 reviews

View all 490 reviews

View all 783 reviews

Drug Class
Side Effects

See also: divalproex sodium side effects in more detail.

See also: Vraylar side effects in more detail.

See also: Lamictal side effects in more detail.
Generic Availability

Lower cost generic

No lower cost generic approved

Lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 80 each
Dosage 500 mg
Per Unit* $1.18
Cost* $94.58

View all divalproex sodium prices

Quantity 20 each
Dosage 1.5 mg
Per Unit* $51.25
Cost* $1,024.98

View all Vraylar prices

Quantity 100 tablet
Dosage 100 mg
Per Unit* $11.77
Cost* $1,177.39

View all Lamictal prices

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Dosage Forms Available
  • Oral delayed release capsule
  • Oral delayed release tablet
  • Oral tablet, extended release
  • Oral capsule
  • Oral tablet
  • Oral tablet, dispersible
Brand Names
Depakote, Depakote ER, Depakote Sprinkles

N/A

 Other lamotrigine brands include: Lamictal CD, Lamictal ODT, Lamictal XR, Subvenite
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

16 hours

504 hours

25.7 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
D
Category D Positive evidence of risk

When Treating Epilepsy And Manic Episodes Associated With Bipolar Disorder

X
Category X Not for use in pregnancy

When Treating Migraine

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 409 drugs are known to interact with divalproex sodium:

  • 23 major drug interactions (61 brand and generic names)
  • 364 moderate drug interactions (2272 brand and generic names)
  • 22 minor drug interactions (200 brand and generic names)

A total of 570 drugs are known to interact with Vraylar:

  • 93 major drug interactions (380 brand and generic names)
  • 476 moderate drug interactions (1808 brand and generic names)
  • 1 minor drug interactions (3 brand and generic names)

A total of 286 drugs are known to interact with Lamictal:

  • 9 major drug interactions (32 brand and generic names)
  • 265 moderate drug interactions (1840 brand and generic names)
  • 12 minor drug interactions (47 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of divalproex sodium such as dizziness... View more
  • Grapefruit juice can increase the blood levels of cariprazine. This may increase side effects such... View more
  • Using cariprazine together with alcohol may increase side effects such as dizziness, drowsiness... View more
  • Alcohol can increase the nervous system side effects of lamoTRIgine such as dizziness, drowsiness... View more
Disease Interactions
First Approval Date

March 10, 1983

N/A

December 27, 1994
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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