Divalproex sodium Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Divalproex sodium	Vraylar (cariprazine)	Caplyta (lumateperone)	Enter another drug to compare

Divalproex sodium

Vraylar (cariprazine)

Caplyta (lumateperone)

Prescription only

Divalproex may be used for the treatment of absence or partial seizures, as a preventive treatment for migraines, and to treat mania associated with bipolar disorder. Divalproex may adversely and... View more

Prescription only

Vraylar is an atypical antipsychotic that is effective for the treatment of schizophrenia and bipolar I disorder. Vraylar is usually well-tolerated and less likely than some other antipsychotics to... View more

Prescription only

Caplyta is an atypical antipsychotic that is used to treat adults with schizophrenia or depression associated with bipolar disorder. Sleepiness is the most common side effect and it should not be... View more

More about Divalproex sodium

More about Vraylar (cariprazine)

More about Caplyta (lumateperone)

Ratings & Reviews

Divalproex sodium has an average rating of 6.6 out of 10 from a total of 512 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 23% reported a negative effect.

Vraylar has an average rating of 6.1 out of 10 from a total of 530 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 32% reported a negative effect.

Caplyta has an average rating of 6.6 out of 10 from a total of 189 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 28% reported a negative effect.

View all 512 reviews

View all 530 reviews

View all 189 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Weight gain (29.9%)
Hair loss (9.8%)
Tiredness (8.2%)
Tremors (7.8%)
Depression (7.2%)
Anxiety (4.5%)
Nausea (4.5%)

View all Divalproex sodium side effects

Restlessness (16.4%)
Insomnia (14.7%)
Weight gain (12.3%)
Nausea (9.8%)
Anxiety (8.9%)
Tiredness (5.8%)
Hallucinations (5.5%)

View all Vraylar side effects

Headaches (14.8%)
Nausea (10.6%)
Dizziness (10.1%)
Dry mouth (10.1%)
Drowsiness (9.5%)
Tiredness (9.0%)
Weight gain (6.9%)

View all Caplyta side effects

Drug Class

Fatty acid derivative anticonvulsants

Atypical antipsychotics

Atypical antipsychotics

Generic Availability

Lower cost generic

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	80 each
Strength	500 mg
Per unit^*	$1.31
Cost^*	$104.54

View all Divalproex sodium prices

Quantity	20 each
Strength	1.5 mg
Per unit^*	$54.55
Cost^*	$1,090.96

View all Vraylar prices

Quantity	30 each
Strength	42 mg
Per unit^*	$61.18
Cost^*	$1,835.40

View all Caplyta prices

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Dosage Forms

Oral delayed release capsule
Oral delayed release tablet
Oral tablet, extended release

Oral capsule

Oral capsule

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

16 hours

504 hours

18 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

When Treating Epilepsy And Manic Episodes Associated With Bipolar Disorder

Category X Not for use in pregnancy

When Treating Migraine

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 426 drugs are known to interact with Divalproex sodium:

24 major drug interactions (68 brand and generic names)
379 moderate drug interactions (2514 brand and generic names)
23 minor drug interactions (203 brand and generic names)

A total of 578 drugs are known to interact with Vraylar:

94 major drug interactions (385 brand and generic names)
482 moderate drug interactions (1838 brand and generic names)
2 minor drug interactions (5 brand and generic names)

A total of 606 drugs are known to interact with Caplyta:

167 major drug interactions (620 brand and generic names)
437 moderate drug interactions (1727 brand and generic names)
2 minor drug interactions (5 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of divalproex sodium such as dizziness... View more

Grapefruit juice can increase the blood levels of cariprazine. This may increase side effects such... View more
Using cariprazine together with alcohol may increase side effects such as dizziness, drowsiness... View more

Grapefruit and grapefruit juice may increase the blood levels of lumateperone. In some cases, this... View more
Using lumateperone together with alcohol may increase side effects such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

March 10, 1983

September 17, 2015

December 20, 2019

WADA Class View classifications

N/A

More Information

Patient Resources

Divalproex sodium uses

Vraylar uses

Caplyta uses

Professional Resources

Prescribing information

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Divalproex sodium Alternatives Compared

See also:

Qulipta

Aimovig

Caplyta

Botox

Nurtec ODT

Vraylar

Abilify

Seroquel

Lamictal

Carbamazepine

Further information

Divalproex sodium Alternatives Compared

See also:

Further information

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