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Tiagabine Side Effects

For the Consumer

Applies to tiagabine: oral capsule, oral tablet

As well as its needed effects, tiagabine may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking tiagabine, check with your doctor or nurse as soon as possible:

More common:
  • Blue or purple spots on skin
  • difficulty in concentrating or paying attention
Less common:
  • Burning, numbness, or tingling sensations
  • clumsiness or unsteadiness
  • confusion
  • itching
  • mental depression
  • speech or language problems
Rare
  • Agitation
  • bloody or cloudy urine
  • burning, pain, or difficulty in urinating
  • frequent urge to urinate
  • generalized weakness
  • hostility
  • memory problems
  • quick to react or overreact emotionally
  • rash
  • uncontrolled back-and-forth and/or rolling eye movements
  • walking in unusual manner
Symptoms of overdose:
  • Agitation (severe)
  • clumsiness or unsteadiness (severe)
  • coma
  • confusion (severe)
  • drowsiness (severe)
  • increase in seizures
  • mental depression
  • severe muscle twitching or jerking
  • sluggishness
  • speech problems (severe)
  • weakness

Minor Side Effects

Some tiagabine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Chills
  • diarrhea
  • dizziness
  • drowsiness
  • fever
  • headache
  • muscle aches or pain
  • nervousness
  • sore throat
  • tremor
  • unusual tiredness or weakness
  • vomiting
Less common:
  • Abdominal pain
  • flushing
  • impaired vision
  • increased appetite
  • increased cough
  • mouth ulcers
  • muscle weakness
  • nausea
  • pain
  • trouble in sleeping

For Healthcare Professionals

Applies to tiagabine: oral tablet

Dermatologic

Very common (10% or more): Common (1% to 10%): Rash, pruritus
Uncommon (0.1% to 1%): Dermatitis bullous dermatitis, bruising
Frequency not reported: Vesiculobullous rash, exfoliative dermatitis[Ref]

Cardiovascular

Common (1% to 10%): Vasodilation[Ref]

Gastrointestinal

Very common (10% or more): Nausea (11%)
Common (1% to 10%): Abdominal pain, diarrhea, vomiting, increased appetite, mouth ulceration[Ref]

Hepatic

Very rare (less than 0.01%): Abnormal hepatic function (elevated SGPT, GGT)[Ref]

Musculoskeletal

Common (1% to 10%): Myasthenia, muscle twitching[Ref]

Immunologic

Very common (10% or more): Infection (15%)
Common (1% to 10%): Influenza syndrome[Ref]

Nervous system

Very common (10% or more): Dizziness (27%), asthenia (20%), somnolence (18%), nervousness (10%), tremor
Common (1% to 10%): Ataxia, paresthesia, abnormal gait, nystagmus, speech disorder
Uncommon (0.1% to 1%): Nonconvulsive status epilepticus
Frequency not reported: Encephalopathy[Ref]

Ocular

Very common (10% or more): Blurred vision, visual field defects
Common (1% to 10%): Amblyopia, diplopia[Ref]

Respiratory

Common (1% to 10%): Pharyngitis, cough, rhinitis[Ref]

Psychiatric

Common (1% to 10%): Difficulty with concentration/attention, insomnia, confusion, memory loss, depressed mood, emotional liability, hostility/aggression, agitation
Uncommon (0.1% to 1%): Depression, psychosis
Rare (0.01% to 0.1%): Hallucinations, delusion[Ref]

Other

Very common (10% or more): Accidental injury (17%)
Common (1% to 10%): Pain (unspecified), fatigue[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Tiagabine Hydrochloride (tiaGABine (tiagabine))." Teva Pharmaceuticals USA, North Wales, PA.

3. Cerner Multum, Inc. "Australian Product Information." O 0

It is possible that some side effects of tiagabine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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