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Tiagabine Dosage

Applies to the following strength(s): 4 mg ; 12 mg ; 16 mg ; 2 mg ; 20 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Seizures

For use in the treatment of partial seizures:

Initial Dose: 4 mg orally once a day. A typical dosage titration regimen is described below for patients concurrently receiving enzyme inducing antiepileptic drugs (EIAEDs) such as phenytoin, carbamazepine, and barbiturates. Patients not concurrently receiving EIAEDs may need slower and more cautious titration regimen than that shown below.

After the first week of therapy, the total daily dose may be increased to 8 mg/day in two divided doses for the second week.

After two weeks, the total daily dose may be increased to 12 mg/day in three divided doses for the third week.

After three weeks, the total daily dose may be increased to 16 mg/day in two to four divided doses for the fourth week.

After four weeks, the total daily dose may be increased from 20 to 24 mg/day in two to four divided doses for the fifth week.

After five weeks, the total daily dose may be increased from 24 to 32 mg/day in two to four divided doses for the sixth week.

The usual maintenance dose ranges from 32 to 56 mg/day in two to four divided doses.

Usual Pediatric Dose for Seizures

Less than 12 years: No dosing guidelines established.

Greater than or equal to 12 years: For use in the treatment of partial seizures:

Initial Dose: 4 mg orally once a day. A typical dosage titration regimen is described below for patients concurrently receiving enzyme inducing antiepileptic drugs (EIAEDs) such as phenytoin, carbamazepine, and barbiturates. Patients not concurrently receiving EIAEDs may need slower and more cautious titration regimen than that shown below.

After the first week of therapy, the total daily dose may be increased to 8 mg/day in two divided doses for the second week.

After two weeks, the total daily dose may be increased to 12 mg/day in three divided doses for the third week.

After three weeks, the total daily dose may be increased to 16 mg/day in two to four divided doses for the fourth week.

After four weeks, the total daily dose may be increased from 20 to 24 mg/day in two to four divided doses for the fifth week.

After five weeks, the total daily dose may be increased from 24 to 32 mg/day in two to four divided doses for the sixth week.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Patients with hepatic dysfunction may need a slower and more cautious titration regimen.

Dose Adjustments

Dosing guidelines for tiagabine have been established only for use as an adjunctive treatment for partial seizures and not for any other indication. The current dosing guidelines for tiagabine have been established primarily for patients with partial epilepsy who are taking hepatic enzyme-inducing anticonvulsant drugs. Patients who are not taking enzyme-inducing drugs would have systemic exposure to tiagabine that is higher than expected. Thus, these patients require lower doses of tiagabine and may require a slower titration rate.

Dialysis

Data not available

Other Comments

Tiagabine should be administered with food.

Modification of concomitant antiepileptic drugs is not necessary, unless it is indicated clinically.

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