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Tiagabine Dosage

Applies to the following strength(s): 4 mg ; 12 mg ; 16 mg ; 2 mg ; 20 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Epilepsy

Patients receiving enzyme-inducing AED regimens:
-Initial dose: 4 mg orally once a day; modification of concomitant antiepilepsy drugs is not necessary, unless clinically indicated
-Titration: The total daily dose may be increased by 4 to 8 mg at weekly intervals until clinical response is achieved or, up to 56 mg/day; the total daily dose should be given in divided doses 2 to 4 times a day
-Maximum dose: 56 mg/day (in 2 to 4 divided doses)

Patients not receiving enzyme-inducing AED regimens:
-The estimated plasma concentrations of this drug in non-induced patients is twice that of patients receiving enzyme-inducing AEDs. Lower doses are required and slower titration may be necessary.

Comments:
-This drug should be taken with food.
-Do not use a loading dose.
-Rapid escalation and/or large dose increments should not be used.
-If a scheduled dose is missed, the patient should not make up for the missed dose by increasing the next dose; if several doses are missed, retitration may be required.
-Dosage adjustment may be needed whenever a change in the patient enzyme-inducing status occurs as a result of the addition, discontinuation, or dose change of the enzyme-inducing agent.

Use: For use as adjunctive therapy in the treatment of partial seizures

Usual Adult Dose for Seizures

Patients receiving enzyme-inducing AED regimens:
-Initial dose: 4 mg orally once a day; modification of concomitant antiepilepsy drugs is not necessary, unless clinically indicated
-Titration: The total daily dose may be increased by 4 to 8 mg at weekly intervals until clinical response is achieved or, up to 56 mg/day; the total daily dose should be given in divided doses 2 to 4 times a day
-Maximum dose: 56 mg/day (in 2 to 4 divided doses)

Patients not receiving enzyme-inducing AED regimens:
-The estimated plasma concentrations of this drug in non-induced patients is twice that of patients receiving enzyme-inducing AEDs. Lower doses are required and slower titration may be necessary.

Comments:
-This drug should be taken with food.
-Do not use a loading dose.
-Rapid escalation and/or large dose increments should not be used.
-If a scheduled dose is missed, the patient should not make up for the missed dose by increasing the next dose; if several doses are missed, retitration may be required.
-Dosage adjustment may be needed whenever a change in the patient enzyme-inducing status occurs as a result of the addition, discontinuation, or dose change of the enzyme-inducing agent.

Use: For use as adjunctive therapy in the treatment of partial seizures

Usual Pediatric Dose for Epilepsy

Less than 12 years: No dosing guidelines established.

Patients 12 years or older receiving enzyme-inducing AED regimens:
-Initial dose: 4 mg orally once a day; modification of concomitant antiepilepsy drugs is not necessary, unless clinically indicated
-Titration: The total daily dose may be increased by 4 mg at the beginning of Week 2; thereafter, the total daily dose may be increased by 4 to 8 mg at weekly intervals until clinical response is achieved or up to 32 mg/day (in divided doses 2 to 4 times a day); doses above 32 mg/day have been tolerated in a small number of adolescent patients for a relatively short duration

Patients 12 years or older not receiving enzyme-inducing AED regimens:
-The estimated plasma concentrations of this drug in non-induced patients is twice that of patients receiving enzyme-inducing AEDs. Lower doses are required and slower titration may be necessary.

Comments:
-This drug should be taken with food.
-Do not use a loading dose.
-Rapid escalation and/or large dose increments of should not be used.
-If a scheduled dose is missed, the patient should not make up for the missed dose by increasing the next dose; if several doses are missed, retitration may be required.
-Dosage adjustment may be needed whenever a change in the patient enzyme-inducing status occurs as a result of the addition, discontinuation, or dose change of the enzyme-inducing agent.

Use: For use as adjunctive therapy in children 12 years and older in the treatment of partial seizures

Usual Pediatric Dose for Seizures

Less than 12 years: No dosing guidelines established.

Patients 12 years or older receiving enzyme-inducing AED regimens:
-Initial dose: 4 mg orally once a day; modification of concomitant antiepilepsy drugs is not necessary, unless clinically indicated
-Titration: The total daily dose may be increased by 4 mg at the beginning of Week 2; thereafter, the total daily dose may be increased by 4 to 8 mg at weekly intervals until clinical response is achieved or up to 32 mg/day (in divided doses 2 to 4 times a day); doses above 32 mg/day have been tolerated in a small number of adolescent patients for a relatively short duration

Patients 12 years or older not receiving enzyme-inducing AED regimens:
-The estimated plasma concentrations of this drug in non-induced patients is twice that of patients receiving enzyme-inducing AEDs. Lower doses are required and slower titration may be necessary.

Comments:
-This drug should be taken with food.
-Do not use a loading dose.
-Rapid escalation and/or large dose increments of should not be used.
-If a scheduled dose is missed, the patient should not make up for the missed dose by increasing the next dose; if several doses are missed, retitration may be required.
-Dosage adjustment may be needed whenever a change in the patient enzyme-inducing status occurs as a result of the addition, discontinuation, or dose change of the enzyme-inducing agent.

Use: For use as adjunctive therapy in children 12 years and older in the treatment of partial seizures

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Reduce the dose and/or prolong the dose interval.

Dose Adjustments

-Consider dosage adjustment when a change in enzyme-inducing status occurs due to the addition, discontinuation, or dose change of the enzyme-inducing agent.
-If multiple doses are missed, evaluate if retitration is clinically indicated.

Dialysis

Data not available

Other Comments

Administration advice:
-This drug should be taken with food.
-Modification of concomitant antiepileptic drugs is not necessary, unless it is indicated clinically.

Patient advice:
-Patients should be informed of the availability of a Medication Guide, and they should be instructed to read it prior to taking this drug.

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