Depakote ER Interactions
There are 424 drugs known to interact with Depakote ER (divalproex sodium), along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 24 are major, 377 are moderate, and 23 are minor.
- View all 424 medications that may interact with Depakote ER
- View Depakote ER alcohol/food interactions (1)
- View Depakote ER disease interactions (8)
Most frequently checked interactions
View interaction reports for Depakote ER (divalproex sodium) and the medicines listed below.
- Abilify (aripiprazole)
- Adderall (amphetamine / dextroamphetamine)
- albuterol
- Ambien (zolpidem)
- Ativan (lorazepam)
- atorvastatin
- clonazepam
- Cymbalta (duloxetine)
- gabapentin
- hydroxyzine
- ibuprofen
- Klonopin (clonazepam)
- Lamictal (lamotrigine)
- levothyroxine
- Lexapro (escitalopram)
- lisinopril
- lorazepam
- Lyrica (pregabalin)
- melatonin
- metformin
- omeprazole
- propranolol
- Prozac (fluoxetine)
- Seroquel (quetiapine)
- Synthroid (levothyroxine)
- Topamax (topiramate)
- trazodone
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zoloft (sertraline)
Depakote ER alcohol/food interactions
There is 1 alcohol/food interaction with Depakote ER (divalproex sodium).
Depakote ER disease interactions
There are 8 disease interactions with Depakote ER (divalproex sodium) which include:
- depression
- liver disease
- urea cycle disorders
- suicidal tendency
- HIV/CMV
- thrombocytopenia
- thyroid function tests
- urine ketone test
Report options
More about Depakote ER (divalproex sodium)
- Depakote ER consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (98)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Generic availability
- Drug class: fatty acid derivative anticonvulsants
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
