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User Reviews for Depakote ER

Depakote ER has an average rating of 7.3 out of 10 from a total of 92 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 12% reported a negative effect.

Condition Avg. Rating Reviews Compare
Bipolar Disorder  
7.3
47 reviews 31 medications
Migraine Prevention  
7.6
22 reviews 34 medications
Epilepsy  
6.8
20 reviews 55 medications
Mania  
8.0
3 reviews 15 medications
Summary of Depakote ER reviews 7.3 92 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Depakote ER

Mood Swing Mama · Taken for less than 1 month October 9, 2019

For Bipolar Disorder: “I must start off by saying everyone is different and will react different. My condition is unofficially diagnosed. But I was told when I was a teenager I was a maniac depressive with possible hormonal imbalance. Recently I have had two major mania events. Accelerated heart rate, palpitations, headaches, dizziness, fatigue, mood swings, confusion, and memory loss to name a few. The night I took this medication I felt it kick in. I felt great and had so much mental energy I didn't have before. It has been working for me. I suggest eating when you take this medication it can make you nauseous. I haven't seen any side effects other than that. Each to their own though. Just wanted to post this to this forum to let you know if this doesn't work for you there is a medication that will work. Don't give up !”

8 / 10
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Jamie STL · Taken for less than 1 month September 9, 2015

For Bipolar Disorder: “I've been taking Depakote ER 500mg at night for 2wks now. I'm Bipolar 1. It's amazing! I've slept great! No side effects. No mood swings. I feel very balanced. I've taken many psych meds over the past 13 yrs. Finally! The right med! I say. Give it a chance if U suffer from severe Bipolar, mood swings, anxiety/panic attacks, sleep disorder...etc. This is working. People close 2 me say I'm a lot calmer now. More rational. Were as b4 I'd quickly lash out! Not now.”

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Carala · Taken for 6 months to 1 year April 4, 2018

For Bipolar Disorder: “I am very pleased so far with my experience taking Depakote. Before Depakote, I was taking seroquel for quite some time (a couple years) and although I was happy on that medicine, I was way too tired. Luckily my solution was Depakote. All I can say is I have tried medicine for 4 years now and it has been a long journey! I will always remember my first time taking Depakote. Normally I get very fearful and panic the med will make me sick. Not Depakote. Instead, I felt immediately better, happy even, and giggled. Once that wore off, I felt normal and slept an hour or two after taking it. I enjoy how I still get tired on this medication like seroquel, but it does not overwhelm my senses with sedation, and fog my memory as much. If anything, I have never been more myself! Only thing is now sometimes I laugh too much.”

10 / 10
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Toban M October 15, 2013

For Migraine Prevention: “I've also been trying different preventive medication for migraines with my doctor and so far Depakote is working the best. I started with 250mg a day for the first week, now at 500 mg a day. Before this medication, I would wake up daily with chronic head pain in the neck or behind the eyes. Now I wake up almost every morning with a clear head. I haven't seen any side effects yet at this dosage and I've even lost weight since I've been proactive with daily exercise. I started walking 2 miles daily since taking this medication. With proactive exercise and eating habits, I think anyone can keep potential side effects at bay. Previously, I was on Topamax and had to stop taking it as the nausea/head fuzz was too severe for my line of work.”

9 / 10
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Madoline December 4, 2017

For Bipolar Disorder: “I have been on generic Depakote for 12 years. Prior to it, I took lithium for 28 years. On Depakote, I lost 30 pounds; and did not have hair loss. I do get tired in the afternoon and take a nap. I feel the medication helps me live a good life. I believe I would be dead without medication that keeps me from being manic.”

9 / 10
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Stacey M April 25, 2013

For Bipolar Disorder: “I was recently hospitalized during a manic episode. I have been treated for bipolar going on 20 years ( I'm 41). I have been on Zyprexa and other medicines for anxiety. I am a rapid cycler (frequent manic episodes). I have tried all the meds from A-Z. It's been a awhile since I've tried Depakote, but it's the first thing they put me on in the hospital. It's been 15 days I think it's ok, but when I lay down I feel like weights are holding me to the bed and I seem to get disorientated as to my location in the house ( weird right??). When I get up all is fine again. If anyone has experienced this please share, it would really help. Let's face it "regular" people would freak just having this discussion. ”

8 / 10
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DebiAvi · Taken for 10 years or more April 7, 2020

For Bipolar Disorder: “I was diagnosed with Bipolar I, forty years ago. On Lithium first. Made me worse. Treated with over 30 drugs, all made me worse, before realizing Depakote ONLY was the Med for me. A doc explained to me that folks who lean towards mania should not take anti-depressants. Hindsight! Then, after years of Benzo’s PRN, I started experiencing interdose withdrawals that wrecked my entire immune system. NEVER take Benzo’s!!! Trying to get off of them almost killed me. I got down to 95 pounds. Also, coming off of them is DANGEROUS! Must be done SLOWLY under the guidance of a medical professional who is experienced with the withdrawal risks and tapering schedules. Google the CNN Lisa Ling special. Now with anything I try one new medicine at a time under close medical supervision. Then I know what it does FOR and TO me. Less is more. After years of being on various cocktails, Depakote alone is best for me.”

8 / 10
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J2 Gal December 1, 2017

For Bipolar Disorder: “I'm going to say this. This medication has been a lifesaver for me. I've been on it for six months now. I take it for migraines, bipolar, and seizures. No noticeable side effects except for a lot of ear popping. I am a lot calmer than what I used to be. My anxiety is still there but it isn't as bad as it was. I can actually function on this medication. My family can be around me now. I used to rapid cycle and have mixed episodes at least ten times a week. Now they're gone. It's nice to be normal for a change. No grandiose delusions. No audible delusions. I am a little bit sleepier than normal. But with a change of diet, I'm okay. No hair falling out. Just the normal hair loss when it comes to the change of weather.”

10 / 10
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SF100 · Taken for 2 to 5 years October 2, 2018

For Bipolar Disorder: “I am a guy who underwent 30 yrs of treatment for anxiety/depression until I was finally correctly diagnosed with BP2 and ADHD. Depakote ER 2000mg at night is my mainstay med. My default mixed states are well-controlled by Depakote. Xanax works as a rescue med at far lower doses than I took before Depakote. Early hair loss (now resolved), no weight gain. I take 20mg Dexedrine daily for ADHD; Depakote doesn't let it trigger hypomania. Ketamine infusions & nose spray cover the depressive side.”

10 / 10
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X21389 · Taken for 1 to 6 months April 20, 2014

For Bipolar Disorder: “Had to take it in conjunction with Seroquel for it to work. Currently on 1g of Depakote ER per day and 50mg of Seroquel per night. With the two mood stabilizers, I am able to take 20mg of Dexedrine ER for my ADHD to focus on work/school without spinning myself into a hypomanic episode. Keep experimenting, until you find what works. I know it can be discouraging, but you'll get there eventually.”

7 / 10
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dave · Taken for 5 to 10 years July 20, 2019

For Bipolar Disorder: “have been taking Depakote 1500 mg for 2 years, find it calms me down, when anxiety is overwhelming. It is worth side effects of weight gain, and hair loss. I keep taking regular dose and don't play around dosage. ”

8 / 10
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Kirdar · Taken for 5 to 10 years March 2, 2013

For Bipolar Disorder: “Depakote ER is the only medicine I can take for my bi-polar. I have side effects to every medicine I've been on for bi-polar. I can't take the generic. It really bothers my stomach. It doesn't do much for depression. Anything I take for depression makes me manic. I have been on almost medications on the market. I have to learn to live with depression and work my hardest to accept it. I've been living with bi-polar for 38 years. I wish that the brand name wasn't so expensive. It's very hard for me to afford but it must come before food if necessary.”

9 / 10
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Cowboy 61 June 22, 2014

For Migraine Prevention: “I have only been taking Depakote ER 500 mg for 10 days now, or maybe I should say nights. I take it at bed time, & was supposed to start taking it twice a day after a week but the upset stomach, the shakes, (or extra nervousness), no sign of relief of my migraines, & I haven't been able to sleep at night either.. I'm going to tell my Dr. that I just can't take it any more.”

1 / 10
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Susyg · Taken for 6 months to 1 year April 27, 2016

For Bipolar Disorder: “Honestly this medicine has saved my life! I went from having multiple long lasting episodes of mania to none. Ya i still get the thoughts but im relaxed and able to make conscious choices now that im on it. The only negative side affect is the hair loss but its temporary, but so worth it. Nothing is better than feeling like you are in control of yourself, and this medicine does this for you dont be scared to ask your doctor about it!”

10 / 10
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Anonymous April 11, 2012

For Migraine Prevention: “I had used this medication for more than 15 years, before it stopped preventing my chronic migraine headaches. I was taking it up to 2000 mg per: night daily and didn't have any side effects of it since the very beginning of taking it (in lower dose, of course) and even when took max dose as described. Had a very easy adjusting to it, also and no unpleasanties whatsoever.”

10 / 10
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Eli Kaito · Taken for 1 to 6 months January 19, 2013

For Bipolar Disorder: “It did help a bit, but you really have to watch out for side effects. I recommend starting a mood journal if you haven't already while taking this medicine. It made me very violent without realizing it.”

5 / 10
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ZeeZee23 April 9, 2011

For Bipolar Disorder: “I was put on Depakote ER and Celexa for depression and anxiety. My mood and depression were helped and it knocked out my migraine headaches completely. I experienced so many horrible side effects though. I gained 50 pounds in the six months I was on this, I lost my hair, I developed tremors that have not completely subsided, I had horrible stomach problems, heartburn, it made me extremely lethargic, libido was gone. This was just my experience with Depakote and if it weren't for all of the side effects I would have stayed on this medication. Hope this helps.”

1 / 10
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CharlotteRosa May 21, 2013

For Migraine Prevention: “Medication was very effective at controlling silent migraines but long term use (more than 10 years) has resulted in a 60 pound weight gain, hair loss and shakiness. Recently have felt very fatigued and confused. ”

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whollottamanicactivityhere October 24, 2011

For Bipolar Disorder: “I've been on DEpakote ER for about 7 years and regularly for 5 years before. I am a rapid cycler I think. Currently prescribed 2000mg/day (1000 in the morning and 1000 in the evening). I notice weight gain (though could be due to less nightly manic behavior and age), some upset stomach at times, overall, I think it stabilizes me. Caffeine does make me feel more alive when on ER. Otherwise feel quite lethargic, apathetic, less motivated. I tend to feel more like I am depressed when taking this medicine. Will look into combination of Anti-depressive. ”

6 / 10
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PamelaCosta February 5, 2014

For Migraine Prevention: “After being on Depakote Er for 8 months, it was really effective in reducing the migraines. As side effects, I never gained one single pound, but the hair loss was just unbearable. I lost half of all my hair. I had to stop taking it, unfortunately. I have always had headaches, since I was a child. Before Depakote, I stayed one month having headaches every single day, had to stay in bed, couldn't even walk, and I felt like I reached the lowest point in my life, I wouldn't be able to live with the pain anymore, I had no life. After 2 weeks on Depakote er 500mg I started getting better. I was having only 8/10 per month. Now I'm on topiramate for 2 weeks, the hair is still falling a lot and the migraines are back, almost everyday.”

8 / 10
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SFLDiver September 8, 2009

For Migraine Prevention: “I have been taking Depakote ER for approximately 4 weeks now with good results. Prior to this medication, I was experiencing frequent dull pressure type headaches, some lasting several days, and occasional short duration sharp migraines. Since using Depakote ER, I have had no migraines and only a couple of very mild and short duration pressure headaches. I realize it's only been a short amount of time on this medication, but the relief has been quite noticeable for me. I have also not experienced any sudden weight gain side effects, however, just prior to starting this medication, I commenced a health eating regimen, which has actually caused me to lose several pounds, and which may be contributing to my weight situation.”

9 / 10
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seanhanamom February 6, 2012

For Migraine Prevention: “My 12 year old son has been having migraines for 2 years now. At first it was only once every few months. However, it progressed to once or twice a week - with vision aura and speech disturbance. I took him to a Pediatric Neurologist and he said it was likely from puberty. He prescribed 500 mg of Depakote ER. It seemed to start working right away. It has been almost 2 months now and he has only had one migraine now in almost 2 months. Far better than before. He hasn't had any of the noticeable side effects - hair loss, weight gain. He takes it before bedtime. It is hard to get him up in the morning but don't know if that is from the medicine or from going to bed too late!”

9 / 10
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SariahMc December 13, 2014

For Bipolar Disorder: “I have been on Depakote ER for 4 months. My dosage is 1500mg a day. I went untreated for many years (18yrs) because I didn't have health care and failure to accept something was wrong even though I was a lot off the wall. After 3 weeks of Depakote my moods were pretty even and stable. I also felt a little numb, I missed my highs, but it was better than being psychotic one minute and crying in another. But at the 4 month mark my hair has started falling out in clumps, that was my only side effect. So I'm now transitioning to lithium. Fingers crossed.”

9 / 10
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blessed5# March 11, 2016

For Bipolar Disorder: “Have been taking this med since 1992 w/ some breaks here and there. I too have been on, what would seem, every med for Bipolar diagnosis. I take 1750mg and also take 400mg of Lamictal (another mood stabilizer which seems to help with the depression) My only issue had been weight gain which remains a problem. 10 years stable, after being hospitalized for 8 months due to manic episode and psychotic break (was only taking Topamax at that time). Would highly recommend.”

9 / 10
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Blaise · Taken for 5 to 10 years March 28, 2020

For Bipolar Disorder: “Wonder drug for me, although I only use it as a rescue med if I get an inkling of mania. I don’t take it all the time because I gain weight and the hair loss is devastating. The upside is that it gives me curly hair (which also hides some of the hair loss). I lose about 50% of my hair volume. The curls slowly relax once I stop taking it. I still had waves two years after I stopped taking it full time. It’s the oddest thing. In addition to adding it as a rescue med, My doctor and I have carefully put together a drug cocktail that works for me. Effexor XR, Risperdal and bupropion. I don’t feel over medicated and it took years to get the formula right. Never stop trying new meds if you aren’t getting good results.”

9 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.