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Depakote ER User Reviews & Ratings (Page 4)

Depakote ER has an average rating of 7.3 out of 10 from a total of 98 reviews on Drugs.com. 64% of reviewers reported a positive experience, while 12% reported a negative experience.

Reviews for Depakote ER

Commonly mentioned side effects
  • Reb...
  • Taken for 10 years or more
  • October 27, 2021

For Epilepsy "72-year-old man with epilepsy diagnosed at 13. Many seizures as a young adult, but seizure-free for approximately 30 years. Take 500 mg Depakote ER twice a day and Dilantin 100 mg twice a day. My side effect has been weight gain. But the medications have been very effective in my case."

8 / 10
Was this helpful?YesNo
1 Report
  • MJR...
  • Taken for 6 months to 1 year
  • April 28, 2021

For Migraine Prevention "This has been the most helpful migraine preventative - my migraines were becoming a full-time disability, and for the first time in a long time, I’m hopeful - my doctor added 20-30 mg of Vyvanse (stimulant - a very low dose) to suppress appetite and lethargy, and it is amazing - no appetite, no weight gain, and I’m energetically working full-time. Fingers crossed it keeps working. Try the stimulant to prevent the weight gain!"

9 / 10
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1 Report
  • Lan...
  • Taken for 2 to 5 years
  • May 19, 2016

For Bipolar Disorder "I've been taking this for a few years, and I have severe headaches often, along with suffering from low back pain, which is constant on my left side, and nothing is soothing it. Laying down is excruciating, and I'm in the process of running tests. This started about 4 months ago, and I have been trying to deal with it and hope that it would eventually go away. It's becoming unbearable."

4 / 10
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9 Report
  • Jan...
  • Taken for 1 to 2 years
  • April 6, 2020

For Epilepsy "Depakote caused an increase in seizure occurrence as well as severity of the seizures. Extreme changes in sleep habits, appetite, behavioral issues, as well as severe and erratic mood changes, vomiting, and regular kidney stones."

1 / 10
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0 Report
  • Ani...
  • Taken for 5 to 10 years
  • August 24, 2013

For Bipolar Disorder "This medicine has been great for me. I do not feel any side effects. I actually lost 25 pounds... I had been on lithium for 28 years."

10 / 10
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49 Report

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  • i2a...
  • Taken for 1 to 6 months
  • April 7, 2014

For Bipolar Disorder "Caused suicidal depression."

1 / 10
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32 Report
  • liv...
  • October 13, 2014

For Bipolar Disorder "Crushed mania fast on 2000 mg/d and currently stable on this dose."

10 / 10
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27 Report
  • HED...
  • September 25, 2009

For Bipolar Disorder "Has helped to slow down my racing thoughts and helped with some of my sleeping issues."

8 / 10
Was this helpful?YesNo
33 Report
  • Syn...
  • October 9, 2009

For Bipolar Disorder "Depakote in use with Zyprexa has given me my life back. I haven't felt this 'normal' in many years."

10 / 10
Was this helpful?YesNo
30 Report
  • be2...
  • Taken for 2 to 5 years
  • June 30, 2015

For Bipolar Disorder "Very smooth mood stabilizer, no side effects. I take 1200 mg/d."

10 / 10
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20 Report
  • Lil...
  • September 8, 2009

For Mania "I have been taking Depakote ER for about 9 months. I have found it helpful for the mania. The bad side effect is that I gained about 30 pounds."

8 / 10
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19 Report
  • cri...
  • January 14, 2012

For Migraine Prevention "This has worked better than anything else I've tried. I have gained weight, though, and I still get the flashes of light and dark spots."

2 / 10
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18 Report
  • Anonymous
  • February 10, 2009

For Epilepsy "I took the medication for two years as a teenager. It stopped the seizures, but I lost all my energy and put on 40 pounds. Once I stopped Depakote, I nearly lost all the weight within 2 months."

5 / 10
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13 Report
  • Cor...
  • May 24, 2015

For Bipolar Disorder "I had a strong desire to drive off the road even with other people in the car. Otherwise, this worked well, but the desire increased the longer I was on it."

7 / 10
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18 Report
  • nic...
  • June 16, 2009

For Epilepsy "I have taken Depakote ER for a while with Lamictal. I have not had a seizure in 34 months. I do have hair loss and weight gain problems."

8 / 10
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13 Report
  • why...
  • Taken for less than 1 month
  • May 5, 2013

For Epilepsy "Severe pain all over after taking, so I had to stop."

2 / 10
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12 Report
  • Joe...
  • Taken for 2 to 5 years
  • July 3, 2019

For Epilepsy "Controls epilepsy but bad side effects: Worst was tremors, which got worse until I got off the drug. Replaced Depakote with Briviact."

2 / 10
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5 Report
  • sun...
  • November 19, 2008

For Epilepsy "Been on for 10 years. Do have breakthrough seizures every 4-5 years (tonic-clonic)."

8 / 10
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8 Report
  • Man...
  • Taken for 1 to 2 years
  • July 14, 2021

For Epilepsy "It stops my seizures, but makes my hands shake like crazy. I can't even write. I shake much more when I have extreme anxiety."

10 / 10
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1 Report
  • JB3...
  • Taken for 1 to 6 months
  • June 10, 2019

For Bipolar Disorder "Not sure if Depakote is worth it. Rather take Seroquel XR."

6 / 10
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5 Report
  • D H...
  • Taken for 10 years or more
  • January 1, 2023

For Epilepsy "Very positive experience with Depakote, now Depakote ER. Monotherapy for tonic-clonic seizures since the 1980s. No seizures since 2004. I take one 125 mg per day."

10 / 10
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0 Report
  • Anonymous
  • November 4, 2009

For Migraine Prevention "Fewer side effects than Depakote but nearly no benefit for migraines."

4 / 10
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3 Report
  • Kan...
  • Taken for less than 1 month
  • May 12, 2018

For Bipolar Disorder "Terrible. Absolute poison. I would never, ever put that toxic waste in my bloodstream again. Depakote is bad."

1 / 10
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10 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.