Lurasidone Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 2, 2024.

Applies to lurasidone: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.

Lurasidone is not approved for the treatment of patients with dementia-related psychosis.

An increased risk of suicidal thoughts and behavior was found in pediatric and young adult patients taking antidepressants.

Monitor for clinical worsening and emergence of suicidal thoughts and behaviors.

Serious side effects of lurasidone

Along with its needed effects, lurasidone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lurasidone:

More common side effects

• absence of or decrease in body movement
• difficulty with swallowing
• drooling
• inability to sit still
• incremental or ratchet-like movement of the muscle
• loss of balance control
• mask-like face
• muscle discomfort
• muscle trembling, jerking, or stiffness
• need to keep moving
• restlessness
• rigid or stiff muscles
• shakiness in the legs, arms, hands, or feet
• shuffling walk
• slow movements
• slow reflexes
• slurred speech
• stiffness of the arms and legs
• tic-like (jerky) movements of the head, face, mouth, and neck
• trembling or shaking of the hands or feet
• twisting movements of the body
• uncontrolled movements, especially of the face, neck, and back

Less common side effects

• arm, back, or jaw pain
• blurred vision
• burning while urinating
• changes in patterns and rhythms of speech
• chest pain or discomfort
• chills
• cold sweats
• confusion
• difficult or painful urination
• difficulty opening the mouth
• difficulty with breathing
• dizziness
• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
• fast, pounding, or irregular heartbeat or pulse
• fixed position of the eye
• headache
• high fever
• inability to move the eyes
• inability to speak
• increased blinking or spasms of the eyelid
• increased sweating
• lockjaw
• loss of bladder control
• muscle spasm, especially of the neck and back
• nervousness
• pale skin
• pounding in the ears
• seizures
• severe muscle stiffness
• severe or sudden headache
• slow or fast heartbeat
• slurred speech
• sticking out of the tongue
• sweating
• temporary blindness
• tiredness
• trouble with breathing, speaking, or swallowing
• troubled breathing with exertion
• uncontrolled twisting movements of the neck, trunk, arms, or legs
• unusual bleeding or bruising
• unusual facial expressions
• unusual tiredness or weakness
• unusually pale skin
• weakness in the arm or leg on one side of the body, sudden and severe

Rare side effects

• black, tarry stools
• bloody urine
• breast pain or swelling
• cough
• dark-colored urine
• decreased frequency or amount of urine
• fever
• increased thirst
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• loss of appetite
• lower back or side pain
• muscle cramp, pain, or stiffness
• nausea
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• swelling of the face, fingers, or lower legs
• swollen glands
• vomiting
• weight gain

Incidence not known

• decreased urine output
• hives or welts, itching, skin rash
• loss of consciousness
• redness of the skin
• swelling of the throat or tongue
• tightness in the chest

Other side effects of lurasidone

Some side effects of lurasidone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• anxiety
• belching
• drowsiness
• dry mouth
• heartburn
• hyperventilation
• indigestion
• irritability
• relaxed and calm feeling
• sleepiness or unusual drowsiness
• stomach discomfort, upset, or pain
• trouble sleeping
• unusually deep sleep
• unusually long duration of sleep

Less common side effects

• abnormal dreams
• back pain
• blurred vision
• burning feeling in the chest or stomach
• decreased appetite
• diarrhea
• feeling of constant movement of self or surroundings
• indigestion
• sensation of spinning
• sweating
• tenderness in the stomach area
• watering of mouth and drooling

Rare side effects

• decreased interest in sexual intercourse
• inability to have or keep an erection
• loss in sexual ability, desire, drive, or performance
• unexpected or excess milk flow from the breasts

For healthcare professionals

Applies to lurasidone: oral tablet.

General adverse events

The most commonly reported adverse events included somnolence, akathisia, extrapyramidal symptoms, and nausea.^[Ref]

Metabolic

• Common (1% to 10%): Decreased appetite, increased appetite, increased weight
• Uncommon (0.1% to 1%): Hyponatremia, increase in blood sugar levels/blood glucose increased^[Ref]

In uncontrolled, long-term schizophrenia trials, this drug was associated with a mean increase in glucose from baseline of 1.8 mg/dL at 24 weeks, 0.8 mg/dL at 36 weeks, and 2.3 mg/dL at 52 weeks. Similar results were observed in bipolar depression studies. The proportion of patients with a 7% or greater increase in body weight was 4.8% (compared with 3.3% for placebo). Pooled data from short-term trials showed a mean weight gain of 0.43 kg in treated patients (compared with -0.2 kg in placebo).^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (up to 17.4%), dyspepsia (up to 11%)
• Common (1% to 10%): Abdominal pain, diarrhea, dry mouth, salivary hypersecretion, stomach discomfort, upper abdominal pain, vomiting
• Uncommon (0.1% to 1%): Dysphagia, flatulence, gastritis
• Frequency not reported: Difficulty swallowing, tongue protrusion, tongue spasm, tongue swelling^[Ref]

Nervous system

• Very common (10% or more): Somnolence (up to 26%), akathisia (up to 22%), extrapyramidal disorder/symptoms (up to 22%), parkinsonism (up to 17%)
• Common (1% to 10%): Dizziness, dyskinesia, dystonia/acute dystonia, tardive dyskinesia
• Uncommon (0.1% to 1%): Cerebrovascular accident/adverse reactions, dysarthria, gait disturbance, lethargy, syncope, vertigo
• Rare (less than 0.1%): Neuroleptic malignant syndrome, seizure
• Frequency not reported: Abnormal glabellar reflex, bradykinesia, cogwheel rigidity, convulsion, drooling, hyperkinesia, hypersomnia, hypersomnolence, hypokinesia, motor impairment, oromandibular dystonia, sedation, stroke, tremor^[Ref]

Akathisia and extrapyramidal symptoms were dose-related.^[Ref]

Psychiatric

• Very common (10% or more): Insomnia (up to 11%)
• Common (1% to 10%): Abnormal dreams, agitation, anxiety, psychomotor hyperactivity, restlessness
• Uncommon (0.1% to 1%): Activation of mania/hypomania, catatonia, nightmare, panic attack, sleep disorder
• Rare (less than 0.1%): Suicidal behavior/ideation
• Frequency not reported: Cognitive impairment, psychomotor retardation^[Ref]

Hematologic

• Uncommon (0.1% to 1%): Anemia
• Rare (less than 0.1%): Eosinophilia
• Frequency not reported: Agranulocytosis, leukopenia, neutropenia^[Ref]

Cardiovascular

• Common (1% to 10%): Hypertension, tachycardia
• Uncommon (0.1% to 1%): Angina pectoris, atrioventricular (AV) block first degree, bradycardia, hot flush, hypotension, increased blood pressure, orthostatic hypotension
• Frequency not reported: Deep vein thrombosis, venous thromboembolism^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain, increased blood creatinine phosphokinase, musculoskeletal stiffness
• Uncommon (0.1% to 1%): Joint stiffness, myalgia, neck pain
• Rare (less than 0.1%): Rhabdomyolysis
• Frequency not reported: Muscle rigidity, muscle spasms, neck muscle spasm, torticollis, trismus^[Ref]

Dermatologic

• Common (1% to 10%): Rash, pruritus
• Uncommon (0.1% to 1%): Hyperhidrosis
• Frequency not reported: , Stevens-Johnson syndrome, urticaria
• Postmarketing reports: Bullous dermatitis, maculopapular rash, pustular rash, severe cutaneous reactions, skin eruption, skin exfoliation^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection
• Uncommon (0.1% to 1%): Amenorrhea, dysmenorrhea, dysuria, erectile dysfunction
• Rare (less than 0.1%): Breast enlargement, breast pain, galactorrhea^[Ref]

Renal

• Common (1% to 10%): Elevated serum creatinine/increased creatinine phosphokinase
• Rare (less than 0.1%): Renal failure^[Ref]

Endocrine

• Uncommon (0.1% to 1%): Elevated prolactin levels/blood prolactin increased
• Frequency not reported: Hyperprolactinemia^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Alanine aminotransferase increased^[Ref]

Hypersensitivity

• Common (1% to 10%): Hypersensitivity
• Rare (less than 0.1%): Angioedema
• Frequency not reported: Allergic rhinitis^[Ref]

Immunologic

• Very common (10% or more): Viral infection (up to 11%)
• Common (1% to 10%): Influenza^[Ref]

Ocular

• Common (1% to 10%): Blurred vision
• Frequency not reported: Oculogyric crisis^[Ref]

Other

• Common (1% to 10%): Fatigue
• Rare (less than 0.1%): Sudden death
• Frequency not reported: Body temperature dysregulation, falls, neonatal drug withdrawal syndrome^[Ref]

Respiratory

• Common (1% to 10%): Nasopharyngitis, oropharyngeal pain, rhinitis
• Frequency not reported: Difficulty breathing, nasal congestion, rhinorrhea, pulmonary embolism, throat tightness, upper respiratory tract infection
• Postmarketing reports: Dyspnea, throat swelling^[Ref]

Frequently asked questions

• Can you stop taking Latuda immediately?
• Does Latuda make you sleepy?
• Is Latuda a mood stabilizer or an antipsychotic?
• How fast does Latuda work?
• Does Latuda cause weight gain?
• Can Latuda be cut in half or split?
• Is Latuda a controlled substance?
• What drugs cause tardive dyskinesia?

Further information

Lurasidone side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer