Perphenazine Side Effects
Medically reviewed by Drugs.com. Last updated on March 11, 2021.
For the Consumer
Applies to perphenazine: oral fixed-combination tablets, oral tablets
Increased Mortality in Geriatric Patients with Dementia-related Psychosis
- Geriatric patients with dementia-related psychosis treated with antipsychotic agents are at an increased risk of death.100 101 102 103 104 o p
- Analyses of 17 placebo-controlled trials in geriatric patients mainly receiving atypical antipsychotic agents revealed an approximate 1.6- to 1.7-fold increase in mortality compared with that in patients receiving placebo.100 101 p
- Most fatalities appeared to result from cardiovascular-related events (e.g., heart failure, sudden death) or infections (mostly pneumonia).100 101 p
- Observational studies suggest that conventional or first-generation antipsychotic agents also may increase mortality in such patients.100 101 103 104
- Antipsychotic agents, including perphenazine, are not approved for the treatment of dementia-related psychosis.100 101 p
Side effects include:
Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia, tardive dyskinesia), drowsiness, muscular weakness, dry mouth, blurred vision, weight gain, skin reactions, amenorrhea, galactorrhea.
For Healthcare Professionals
Applies to perphenazine: compounding powder, injectable solution, oral concentrate, oral tablet
Convulsive seizures occurred most frequently in patients with EEG abnormalities and/or patients with a history of convulsive seizures.
Drowsiness usually occurred within the first 1 to 2 weeks, with gradual disappearance thereafter.
NMS occurred in patients who took neuroleptic drugs, and was fatal in some cases. NMS was characterized by severe extrapyramidal dysfunction, rigidity, stupor, coma, hyperthermia, and/or autonomic disturbances.
Significant autonomic effects were infrequently reported in patients who received less than 24 mg/day.[Ref]
Frequency not reported: Extrapyramidal symptoms, opisthotonos, motor restlessness, hyperreflexia, dystonia, slurred speech, akathisia, dyskinesia, parkinsonism, ataxia, drowsiness, sedation, hypnosis, lethargy, cerebral edema, convulsive seizures, hyperactivity
Postmarketing reports: Headaches, choreiform movements of the extremities, orofacial dyskinesia, tardive dyskinesia, disturbances in consciousness, somnolence, stupor, dizziness, tremor, epileptic fits, neuroleptic malignant syndrome (NMS), severe extrapyramidal dysfunction, coma, autonomic disturbances, cerebrospinal fluid protein abnormalities[Ref]
Frequency not reported: Pallor, hypertension, change in pulse rate, circulatory collapse, postural hypotension, bradycardia, peripheral edema, shock-like condition (hypotensive effect), reversible and nonspecific ECG changes
Postmarketing reports: Tachycardia, QT prolongation, ventricular arrhythmias, ventricular tachycardia/fibrillation, edema, cardiovascular effects (related to neuroleptic malignant syndrome), hypotension, venous thromboembolism, deep vein thrombosis, cardiac arrest and Torsades de pointes[Ref]
Tachycardia occurred more commonly with sudden, marked increases in dose.[Ref]
Frequency not reported: Oculogyric crisis, myosis, mydriasis, glaucoma, photophobia, epithelial keratopathies
Frequency not reported: Exacerbation of psychotic symptoms, catatonia/catatonic-like states, paranoid reactions, nocturnal confusion, bizarre dreams, libido changes,
Frequency not reported: Anorexia, hypoglycemia, polyphagia, increased appetite
Postmarketing reports: Weight gain, hyperglycemia, increased serum cholesterol[Ref]
Frequency not reported: Throat tightness, asthma, laryngeal edema
Frequency not reported: Fever/hyperpyrexia, reversed epinephrine effect
Postmarketing reports: Fatigue, body temperature dysregulation, hyperthermia, sudden unexplained death, neonatal drug withdrawal syndrome[Ref]
Frequency not reported: Syndrome of inappropriate antidiuretic hormone (ADH) secretion, protein bound iodine (PBI) increase not attributable to an increase in thyroxine
Postmarketing reports: Hyperprolactinemia, gynecomastia (males), false positive pregnancy tests[Ref]
Frequency not reported: Liver damage/biliary stasis, infectious hepatitis
Frequency not reported: Anaphylactoid reactions[Ref]
Frequency not reported: Glycosuria[Ref]
Postmarketing reports: Urinary hesitancy/retention/incontinence, amenorrhea, erectile dysfunction, impaired ejaculation, lactation, galactorrhea, moderate breast enlargement (females), bladder paralysis, polyuria, menstruation with decreased bleeding or disturbances in the menstrual cycle[Ref]
Postmarketing reports: Antinuclear antibodies[Ref]
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. "Product Information. Trilafon (perphenazine)" Schering Corporation, Kenilworth, NJ.
More about perphenazine
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Some side effects may not be reported. You may report them to the FDA.