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User Reviews for Prochlorperazine

Also known as: Compro

Prochlorperazine has an average rating of 2.9 out of 10 from a total of 407 ratings on Drugs.com. 18% of reviewers reported a positive experience, while 76% reported a negative experience.

Condition Avg. Rating Reviews Compare
Nausea/Vomiting  
3.1
313 reviews 159 medications
Anxiety  
2.1
84 reviews 54 medications
Psychosis  
2.3
8 reviews 18 medications
Hiccups  Off-label
5.0
1 reviews 2 medications
Migraine  Off-label
1.0
1 reviews 88 medications
Summary of Prochlorperazine reviews 2.9 407 reviews

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Prochlorperazine

Evey · Taken for less than 1 month · May 7, 2021

Compazine (prochlorperazine) for Anxiety: “I went to ER twice for migraines and both times they gave me compazine. The worst experience of my life. I felt like I was gonna tear the walls down like I just wanted to tell everyone to shut up, I couldn’t stand the noise or the talking. I couldn’t even stand my phone ringing and me having to answer, I didn’t even want to text. Now I suffer from severe anxiety and I have never felt so restless, agitated, anxious. I thought I was gonna pull my hair out. Since I drove my self to ER I had to drive myself back which I made it home but while home I wanted to just jump out of my window I took one Benedryl and it didn’t help, it just made me feel more restless I had to take Ativan and it help to the point where I was able to sleep but even in my sleep I was jittery and still a bit anxious shaking. My husband doesn’t believe me and it is hard to explain but now that I read these stories I know now I’m allergic to compazine.”

4 / 10
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Cat · Taken for less than 1 month · March 2, 2020

Compazine (prochlorperazine) for Anxiety: “I should not have been given this drug in the emergency room. As soon as it was given, an extreme heat went through me. I immediately felt panicked, like the walls were closing in. I didn't feel like I was in my body. I kept begging for a reversal. I kept saying I was allergic. My skin felt like it needed to be taken off. I heard voices in my head and couldn't stop moving. I was crying and screaming for help. This medication made me feel like it was the end of me, like everyone was trying to hurt me. This "didn't" go away in an hour. It took days. I am still scared and frightened.”

1 / 10
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Maggie · September 14, 2020

Compazine (prochlorperazine) for Anxiety: “I was seen in the ER last night for a migraine I had had for 2 days. Feeling thankful I was finally going to get some relief they gave me a dose of Benadryl and Compazine through the IV along with fluids. About 3-4 minutes later I was climbing out of the hospital bed, crying, pulling off my bp cuff and IV. I have never in my life felt like this. I work in healthcare and have never seen this either. I thought I was alone until I read everyone’s comments. Never again will I ever take this drug. The headache was gone but the aftermath was so bad I would have rather kept the headache. It’s been over 24 hours and I still feel like I can’t sleep or sit still. Worst thing ever! They tried to reverse the drug and gave me something to relax me. I don’t know when this feeling will go away or if it even will. Worst and I mean worst feeling I’ve ever had!”

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Anonymous · Taken for less than 1 month · March 18, 2021

Compazine (prochlorperazine): “Please, please if you have any type of manic disorder or are prone to have anxiety, please reconsider this drug. This was one of the scariest nights of my life when I was administered this in the ER. Within 15 minutes, I immediately felt off. My body was on fire and I couldn’t stop sweating, and then my heart was racing. I couldn’t control my anxiety. Then, my legs started having spasms and I couldn’t stay still. It felt like the world was closing in and I genuinely remember thinking I was going to die that night. I even tried to rip my own IV out. It amazes me that a medicine like this is still around. I’ve never been in a state of psychosis this badly and I encourage you to please PLEASE really reconsider this drug.”

1 / 10
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TransplantGal · December 20, 2019

Compazine (prochlorperazine) for Nausea/Vomiting: “I was hospitalized for 4 days due to infection. Well, one of the nurses asked me if I felt nauseous and I shouldve said NO because I was barely nauseous. She gave me compazine over IV, and the worse feeling of dread, terror, anxiety, heart palpitations, restlessness, and panic took control over me for a whole week. Even, after I was discharged, I had extreme panic attacks even in the middle of the night. While at the hospital, I wanted to keep running away and scream, just to get away from the overwhelming feeling of HORROR. My husband had to keep praying for me. I couldn't sleep. The final night before the medicine finally wore off was when I started hyperventilating my husband had to literally slapped my face 4 times to calm me down! Because of that one medication, I developed a phobia of taking medicines and sometimes eating new food. I had never known panic or anxiety ever before compazine. It still grips me with fear”

1 / 10
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Tiffany · Taken for less than 1 month · January 5, 2020

Compazine (prochlorperazine) for Nausea/Vomiting: “It’s been 2 weeks and I am still feeling the terrible side effects (pacing, tremors, etc) For those of you that have posted previously, can you please provide updates on how long it took to feel like yourself again? I need some hope that this will go away. :(”

1 / 10
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Manders · Taken for less than 1 month · November 5, 2020

Compazine (prochlorperazine) for Nausea/Vomiting: “Another horror story about Compazine. I went to the ER with a migraine and neck pain that would not break. The doctor gave me their “migraine cocktail” and a few minutes later I started shaking. I struggle with anxiety and was obviously upset because of the headache, so at first I thought that was it. However, as time went on I got more and more agitated. I couldn’t sit still or stop moving my legs. I wanted to rip out my IV and leave! I even tried to disconnect it a few times. Eventually I just sat there, crying and rocking back and forth on my bed like I was going crazy. I told the doctor how I was feeling and she said it was common. She gave me some Ativan which helped after 2 or 3 hours. I’m so thankful I was able to sleep after that. What a terrifying experience. I will be putting this on my allergy list. Please check before you get a “migraine cocktail!””

1 / 10
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Bmr22 · Taken for less than 1 month · December 17, 2019

Compazine (prochlorperazine) for Anxiety: “Last week I was sent to the ER for a terrible migraine and anxiety/panic attack. They gave me tylenol, Benadryl, and Compazine as a migraine cocktail they called it. As they gave me Compazine they told me that it would cause me to have more anxiety. I have never experienced the feeling that I had after being given Compazine. I was extremely panicked and couldn’t stay still. I wanted to rip out my IV and just felt like I had to leave and go home. I told the nurse I was feeling like I had to leave and extremely panicked and restless. I couldn’t calm down and felt like I was fighting against my own body. The nurses just told me that they warned me that it would cause more anxiety. I still can’t figure out why they would give me that knowing I was already having anxiety. I will never ever take Compazine again.”

1 / 10
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Leigh · Taken for less than 1 month · June 24, 2020

Compazine (prochlorperazine) for Nausea/Vomiting: “Do not take this medicine!!! I was given compazine (stemetil) in an injection I immediately had anxiety and my heart rate went up so fast. It’s now day 3 I still have inner restlessness and severe anxiety. Symptoms of akathasia. I’m hoping to goes away soon I cannot sit still I feel tired but can’t sleep. This medicine should be banned!!!!!”

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Oxy-Alex · Taken for less than 1 month · February 10, 2020

Compazine (prochlorperazine) for Anxiety: “(Male, 24) I have severe Crohn's disease and have been around the block a few times when it comes to nausea meds. At one point while admitted in the hospital, I was given Compazine intravenously to alleviate my nausea symptoms. After about 10 minutes or so, I started to experience a SEVERE panic attack. I was convulsing, I started to rip out my hair, and I no longer could speak words. Therefore I wasn't able to properly tell the nurse what was wrong with me. The physical sensations of panic and the illogical thought process I was experiencing were so powerful, that for a moment I considered taking my own life, just to make it stop. I endured this feeling for more than 15 minutes before the night Doctor was able to arrive and properly sedate me. That was one of the most traumatizing experiences of my life.. I literally wanted my life to be over.”

1 / 10
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EGM · September 25, 2020

Compazine (prochlorperazine) for Anxiety: “I was admitted to the ER for a severe migraine. They did the usual migraine cocktail + anti nausea med (Compazine). I'd not heard of it before. Within 60 seconds my world felt like it was coming to a complete end. I felt as though I was out of my own body, trapped in my skin. I was on fire. I tore my BP cuff off. I was on all fours on the ER bed, rocking, crying, hitting the call light like my life depended on it. For what felt like hours, I waited. And my poor boyfriend watched in horror. I sobbed, I begged him to get me out of there. I remember what last shred of sanity I felt as I looked at my IV and began to mentally disassemble it, thinking how I'd get it out of me. I wanted to run. I wanted to die on the floor. Finally, the nurse came. All I gasped was 'I'm falling apart, I can't breathe. Please help!'. I was given IV Ativan. Within ~30 seconds, I felt my heart rate slowing and I didn't want to climb the walls into the ceiling. Worst experience of my life. Never AGAIN!”

1 / 10
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Luna · November 7, 2019

Compazine (prochlorperazine) for Anxiety: “I went to the ER last night for a migraine and other issues. I was given a Compazine cocktail. My migraine was much better. But a few minutes later while I was talking to the dr I started getting extremely panicked. Like I couldn’t be there anymore. I wanted to rip my IV out. I canceled my ultrasound test so I could get out quicker. My husband told the dr and nurse I was have extreme anxiety and they both kept shrugging it off. I just kept yelling I want to go home! I took off my blood pressure cuff. My heart monitor & I would have ripped that IV out too. I attributed it to my panic attacks I get occasionally. My husband kept saying I bet it’s the medications. Well. The new nurse comes in and knew what was wrong with me. Saying it can cause “uneasiness” in people. I am now suffering PTSD. Severe panic of ending up in the hospital for what’s wrong with me. I have been up and down all day even though my body is exhausted. I can not believe this many people have had the same experiences.”

1 / 10
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Akasurvive · Taken for less than 1 month · November 6, 2019

Compazine (prochlorperazine) for Nausea/Vomiting: “Just for the record, the reviews on this site are absolutely real. I know because it happened to me, and I’ve talked to at least a heap people over the past 2 years who have experienced its bad side effects as well. This drug causes akathisia in some which is why so many of the reviews are similar. Just because it didn’t happen to you doesn’t mean it doesn’t happen. Compazine ruined my life and I only took it ONCE. Proceed with caution.”

1 / 10
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Nbc0302 · September 4, 2020

Compazine (prochlorperazine) for Anxiety: “I went to the ER 4 days ago with what was assumed to be a horrible migraine. I’ve had them since I was 12 but had never had anything like this. When I got there the dr was very cold and dismissive when I was terrified. Long story short, she said she was going to order me to get toradol, Benadryl, and Compazine (the migraine concoction). I have had toradol before and everyone has had Benadryl so I wasn’t concerned. It took forever for me to get it and within less than I minute I felt like I was having a heart attack. I do have panic disorder but this was different, I started sweating profusely, I was nauseous, my heart rate and my blood pressure skyrocketed, I felt that I was trying to come out of my own skin and there was zero way to make it stop. I begged to have it reversed and they gave me Ativan which did not work and I refused another dose of Ativan because I was too scared to get any other medications. After days of feeling horrible I will never have this drug again”

1 / 10
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LM · November 18, 2019

Compazine (prochlorperazine) for Nausea/Vomiting: “I can promise you these negative reviews are not false. Just because it didn't happen to you, doesn't mean it didn't happen to us. This medication is horrible! It should not be used for anything. I went to the ER a few years ago and my life hasn't been the same since. The panic attacks I developed after that medication were brutal. Never had panic symptoms before that night I went to the ER. It took me a long time to recover from that medication. Do not take it!”

1 / 10
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Catleen186 · Taken for less than 1 month · July 1, 2013

Compazine (prochlorperazine) for Anxiety: “I was first given Compazine in the hospital for severe nausea associated with a migraine. I suffer from migraines, generalize anxiety, and panic attacks but I was admitted to the hospital due to the worst panic attack I've ever had. They were giving me Valium, but cautiously. When the nurse gave me Compazine for the first time, my nausea and anxiety left at the same time, and quickly too. I was able to finally rest/sleep comfortably. Even though it is prescribed for nausea, I would recommend asking your Doctor about Compazine for anxiety. It will make you sleepy, but like I said, the feeling of be comfortable in my own skin for a change is worth it.”

9 / 10
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Ashley · Taken for less than 1 month · October 28, 2020

Compazine (prochlorperazine) for Nausea/Vomiting: “I received Compazine, via IV, in hospital for vomiting. Within 20 minutes I was pulling off my clothes, my heart was racing and I was having suicidal thoughts. I was legitimately in a full blown psychotic attack, which has never happened before. Hours later I still felt jittery anxious and could not sit still. I will NEVER take this medication again. It stopped my vomiting, however; I’d rather vomit that experience psychosis. Worst experience ever. Never again.”

1 / 10
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Kate · May 9, 2019

Compazine (prochlorperazine) for Anxiety: “I wish there was the option to rate this drug a zero. Compazine is hands down THE WORST MEDICATION I have EVER had. They gave me this in the ER with tordol for a migraine after asking them please don’t try something new because I know what works and doesn’t. The Doctor didn’t care or listen and gave this to me. I will try and best explain how it made me feel: I have never been so afraid in all my life. I felt like I was going to die and my mom had to keep telling me I was ok. My heart rate shot way up and I felt like I was coming out of my skin and being buried alive all while not being able to move .I felt like I couldn’t breathe like something was suffocating me. I kept asking my mom to pray for me right then and there because I didn’t want to die but was certain I was going to. I didn’t want them to give me anything else because I was so fearful for my life. This drug should be taken off the market and banned”

1 / 10
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Robert · Taken for less than 1 month · February 3, 2020

Compazine (prochlorperazine) for Anxiety: “Just got out of the ER with my daughter. She got the "migraine cocktail" with Compazine as well. She became irritable at the hospital and just wanted to leave. They finally discharged her and she started feeling nauseous on way home. Has been vomiting for an hour now and full of anxiety. She's begging for it "to just stop." Nothing online for a counter agent. I am annoyed because my wife mentioned the drug gave her lock jaw as a child but the Dr said drug allergies/reactions are not hereditary. And he also never mentioned any side effects until we got home and called back to find out if she needed to return. It may work for some people but be wary. My family is no longer taking it. Two strikes and you are out.”

1 / 10
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Lolo · Taken for less than 1 month · March 23, 2020

For Nausea/Vomiting: “This medication worked wonders for me. I took 10mg for massive migraine and nausea. After 5 days with the worse headache and nausea, this brought relief within 20 minutes. For me, my experience was amazing and saved me a trip to the ER during all of this COVID-19 madness.”

10 / 10
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Anonymous · Taken for less than 1 month · January 6, 2019

Compazine (prochlorperazine) for Anxiety: “I went in for severe migraine. They never told me the side affects. After 15 mins of it I thought I was going to jump out of my skin. I was nervous scared. I had to call my mom crying to come get me out of there. I took my blood pressure cuff of and kept walking to the bathroom and just trying to pace. I had no idea it was the medicine until before I left. I asked what was wrong with me. They told me it was normal affects from this drug. For 24 hours I had to take 2 Benadryl every 4 hours to keep me knocked out because my heart was racing soooo hard and thought something was going to happen to me. It’s been 36 hours and I still have anxiety. This stuff should not be given to anyone. It’s HORRRRRRIBLE!”

6 / 10
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Anonymous · October 18, 2020

Compazine (prochlorperazine) for Psychosis: “Was seen in the ER for a terrible migraine, I have been seen in this ER a few times for really bad migraines and I've always been given Toradol/ phenergin which had always worked. Well this time my doctor says screw what works and gave me some "migraine cocktail" with compazine and benadryl...about 2 minutes later I was absolutely losing my mind! I felt like my skin was crawling off my body! I couldn't sit still I just wanted to be out of my skin! I had ripped my blood pressure cuff and oxygen off and was punching the wall and jumping up and down! I've never acted like this before and have never ever ever had anything like this happen! I seriously would have run out into traffic if it meant that I would not feel like this anymore! Finally a nurse comes in and gives me ativan whch alleviates my psychosis”

1 / 10
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Dani · Taken for less than 1 month · July 16, 2019

For Nausea/Vomiting: “I’m so surprised reading all the reviews of this drug! One evening I opened my eyes, and the room was just SPINNING - I was terrified and couldn’t even get up or walk. My roommates had to help me to the doctor where I was diagnosed with vestibular neuritis with vertigo. The doctor wanted to prescribe me regular gravol but I insisted I needed something more, I was so horribly sick. He prescribed me 5mg of prochlorazine and I found it helps to prevent vertigo attacks as well as really helps manage them. I have panic disorder, chronic anxiety & depression and I haven’t experienced any of these side effects! I find it actually relaxes me and takes care of the nausea and dizziness quick. Maybe I’m just psychotic and meant to be on this med! Haha”

8 / 10
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lxs124 · March 19, 2021

Compazine (prochlorperazine) for Nausea/Vomiting: “I went to the Urgent Care for an especially debilitating migraine and was given some medication through an IV. Almost immediately I felt like ripping out my IV jumping off the TOP of the building!! Finally the nurse came in and kinda chuckled at my sobbing hysterical state saying that, "Some patients have this kind of reaction to Compazine but you can be glad it's all done." But for awhile after I kept going to the restroom thinking if I just did a "normal thing" like peeing I would suddenly feel "normal again" but I continued to feel panicked. I got Benadryl through an IV and I fell asleep. When I woke up I was FRANTIC to get out of there. I still had a bad headache and felt so panicky but had to get out of there because I was so afraid. I learned that reaction is called a PANIC ATTACK and have had several more since then. I still get migraines too but know to never again accept treatment at all similar to this nightmare drug.”

1 / 10
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NuseNoName · Taken for less than 1 month · July 17, 2020

For Anxiety: “So.. I suffer real bad with anxiety. And I mean real bad. The smallest change/bad thought can set off horrific nausea and vomiting at any given moment. (I’m a Prison nurse so this doesn’t work well in my favour at all). The only thing that worked for me was “ prochlorperazine 3mg buccal tablets” prescribed by my GP. I CANNOT EXPRESS WHAT A BREATH OF FRESH AIR THESE ARE!!! My anxiety can last days/weeks at a time causing massive weight loss. Within an hour of taking these, my nausea vomiting and any anxious thoughts are gone. These may not work for everyone, but for me at 27 years old, I’ve finally found my medication!!!”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.