Skip to main content

Compro (rectal)

Generic name: prochlorperazine (rectal) [ pro-klor-PER-a-zeen ]
Brand name: Compro
Drug classes: Phenothiazine antiemetics, Phenothiazine antipsychotics

Medically reviewed by on Apr 15, 2024. Written by Cerner Multum.

What is rectal Compro?

Compro is used to control severe nausea and vomiting in adults.

Compro may also be used for purposes not listed in this medication guide.

Rectal Compro side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

High doses or long-term use of prochlorperazine can cause a serious movement disorder that may not be reversible. The longer you use Compro, the more likely you are to develop this disorder, especially if you are a diabetic or an older adult.

Compro may cause serious side effects. Call your doctor at once if you have:

Side effects such as dry mouth, constipation, confusion, and tremors may be more likely in older adults.

Common side effects of Compro may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not use Compro if you have recently used alcohol, sedatives, tranquilizers, or opioid medication.

Compro is not approved for use in older adults with dementia-related psychosis.

Do not give Compro to a child younger than 2 years old or weighing less than 20 pounds.

Before taking this medicine

You should not use Compro if you are allergic to it, or if you have recently used alcohol, sedatives, tranquilizers, or opioid medication.

Do not give this medicine to a child younger than 2 years old or weighing less than 20 pounds. Talk with your doctor before giving this medicine to a child of any age who has been ill with a fever or flu symptoms.

Compro may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

Tell your doctor if you have ever had:

Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are using Compro.

Tell your doctor if you are pregnant. Using Compro in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

How should I use rectal Compro?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not take a rectal suppository by mouth. It is for use only in your rectum.

Wash your hands before and after inserting the suppository.

Remove the wrapper before inserting the suppository. Avoid handling the suppository too long or it will melt. Lie on your back with your knees up toward your chest. Gently insert the suppository into your rectum about 1 inch, pointed tip first.

Stay lying down for a few minutes while the suppository melts. You should feel little or no discomfort. Avoid using the bathroom for at least an hour.

Try to empty your bowel and bladder just before using the Compro suppository.

If you need surgery or a medical procedure, tell the doctor you currently use Compro.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause dry mouth, constipation, bloating or stomach cramps, extreme drowsiness or feeling restless and agitated, changes in heart rate, fever, and fainting.

What should I avoid while using rectal Compro?

Avoid driving or operating machinery until you know how Compro will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Drinking alcohol with this medicine can cause side effects.

What other drugs will affect rectal Compro?

Using Compro with other drugs that slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Many drugs can affect Compro. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.