Prochlorperazine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Prochlorperazine	Ubrelvy (ubrogepant)	Sumatriptan	Enter another drug to compare

Prochlorperazine

Ubrelvy (ubrogepant)

Sumatriptan

Prescription and OTC

Prochlorperazine may be used in the treatment of schizophrenia, anxiety, severe nausea, and vomiting. It is associated with a wide range of side effects, including drowsiness, and is not suitable for... View more

Prescription only

Ubrelvy is a prescription medicine that may be used to treat acute migraine attacks in adults and works by blocking the effects of a protein, called CGRP that is thought to play a role in migraine... View more

Prescription only

Sumatriptan may be used to quickly relieve the symptoms of a migraine but may not be suitable for everyone including those with pre-existing cardiovascular conditions. Prescribed for Migraine... View more

More about Prochlorperazine

More about Ubrelvy (ubrogepant)

More about Sumatriptan

Ratings & Reviews

Prochlorperazine has an average rating of 3.1 out of 10 from a total of 461 ratings on Drugs.com. 19% of reviewers reported a positive effect, while 74% reported a negative effect.

Ubrelvy has an average rating of 6.4 out of 10 from a total of 265 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 35% reported a negative effect.

Sumatriptan has an average rating of 7.7 out of 10 from a total of 549 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 17% reported a negative effect.

View all 461 reviews

View all 265 reviews

View all 549 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Anxiety (38.4%)
Panic attacks (18.9%)
Nausea (15.4%)
Restlessness (12.1%)
Tremors (8.9%)
Vomiting (7.2%)
Dizziness (6.3%)

View all Prochlorperazine side effects

Nausea (17.4%)
Tiredness (7.2%)
Dizziness (6.8%)
Drowsiness (5.7%)
Vomiting (5.3%)
Headaches (4.5%)
Sleepy (4.2%)

View all Ubrelvy side effects

Nausea (13.5%)
Drowsiness (6.6%)
Pain (6.4%)
Chest pain (5.1%)
Dizziness (5.1%)
Vomiting (4.4%)
Tiredness (4.2%)

View all Sumatriptan side effects

Drug Class

CGRP inhibitors

Antimigraine agents

Generic Availability

Lower cost generic

No lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	6 tablet
Strength	10 mg
Per unit^*	$1.93
Cost^*	$11.55

View all Prochlorperazine prices

Quantity	10 tablet
Strength	100 mg
Per unit^*	$116.81
Cost^*	$1,168.10

View all Ubrelvy prices

Quantity	0.5 mL
Strength	6 mg/0.5 mL
Per unit^*	$41.00 - $105.76
Cost^*	$20.50 - $52.88

View all Sumatriptan prices

Get free Discount Card

Dosage Forms

Injectable solution
Oral tablet
Rectal suppository

Oral tablet

Nasal spray
Oral tablet
Subcutaneous solution

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

23 hours

7 hours

6 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category N Not classified

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 686 drugs are known to interact with Prochlorperazine:

95 major drug interactions (347 brand and generic names)
578 moderate drug interactions (2464 brand and generic names)
13 minor drug interactions (46 brand and generic names)

A total of 248 drugs are known to interact with Ubrelvy:

38 major drug interactions (96 brand and generic names)
209 moderate drug interactions (600 brand and generic names)
1 minor drug interactions (2 brand and generic names)

A total of 100 drugs are known to interact with Sumatriptan:

70 major drug interactions (279 brand and generic names)
30 moderate drug interactions (166 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using prochlorperazine together with alcohol. This can cause uncontrollable... View more

Grapefruit and grapefruit juice can increase the blood levels of ubrogepant. This may increase... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

October 23, 1956

December 23, 2019

January 28, 2016

WADA Class View classifications

N/A

More Information

Patient Resources

Prochlorperazine uses

Ubrelvy uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Prochlorperazine Alternatives Compared

Further information

Compare Drugs