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Prochlorperazine Dosage

Medically reviewed by Drugs.com. Last updated on Apr 14, 2023.

Applies to the following strengths: 5 mg/mL; 10 mg; 15 mg; 2.5 mg; 5 mg; 25 mg; 5 mg/5 mL; edisylate; maleate

Usual Adult Dose for Nausea/Vomiting

Severe Nausea and Vomiting:
Oral:


Parenteral:
IM:

IV:

Rectal:

Adult Surgery (Severe Nausea and Vomiting):
Parenteral:
IM:

IV:

Comments:

Use: Control of severe nausea and vomiting

Usual Adult Dose for Anxiety

Oral:


Use: Short-term treatment of generalized non-psychotic anxiety

Usual Adult Dose for Psychosis

Mild psychotic disorders:


Moderate to severe psychotic disorders:
Oral:

Parenteral:

Comments:

Use: Treatment of schizophrenia

Usual Adult Dose for Schizophrenia

Mild psychotic disorders:


Moderate to severe psychotic disorders:
Oral:

Parenteral:

Comments:

Use: Treatment of schizophrenia

Usual Pediatric Dose for Nausea/Vomiting

Less than 2 years or less than 9 kg: Use is contraindicated

2 years and older:
Oral:
9 to 13 kg: 2.5 mg orally 1 to 2 times a day; maximum dose is 7.5 mg/day
13 to 18 kg: 2.5 mg orally 2 to 3 times a day; maximum dose is 10 mg/day
18 to 39 kg: 2.5 mg orally 3 times a day OR 5 mg orally 2 times a day; maximum dose is 15 mg/day

Parenteral:


Comments:

Use: Control of severe nausea and vomiting

Usual Pediatric Dose for Schizophrenia

Less than 2 years or less than 9 kg: Use is contraindicated

2 to 12 years:
Oral:


Parenteral:

Comments:

Use: Treatment of schizophrenia

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Liver dysfunction: Data not available

Abnormal liver function tests with grippe-like symptoms and fever: Treatment should be discontinued.

Dose Adjustments

Debilitated, emaciated, and/or elderly patients: Most patients respond to doses in the lower end of the dosing range. If required, dose titration should be performed gradually and patients should be closely monitored for side effects.

Depressed WBC counts with differential: Treatment should be discontinued and appropriate antibiotic therapy should be started.

Precautions

US BOXED WARNING(S): INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS: This drug has an increased risk of mortality when administered to elderly patients with dementia-related psychosis. Elderly patients with dementia-related psychosis treated with antipsychotic drugs have an increased risk of death. This drug is not approved for use in patients with dementia-related psychosis.

Safety and efficacy have not been established in patients younger than 2 years or less than 9 kg.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.