Perphenazine Pregnancy and Breastfeeding Warnings
Medically reviewed by Drugs.com. Last updated on Apr 14, 2023.
Perphenazine is also known as: Trilafon
Perphenazine Pregnancy Warnings
Animal reproduction studies have not been conducted with this drug. There are no controlled data in human pregnancy.
US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Pregnancy categories A, B, C, D, and X are being phased out.
This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus.
US FDA pregnancy category: Not formally assigned
Risk Summary: Neonates exposed during the third trimester are at risk of developing severe and/or prolonged side effects (e.g., agitation, hyper/hypotonia, tremor, somnolence, respiratory distress, feeding disorder). The side effects have varied in severity and duration, with some neonates requiring intensive care support and prolonged hospitalization.
Comment:
-Exposed neonates should be monitored for the signs/symptoms of extrapyramidal syndrome and/or withdrawal.
Perphenazine Breastfeeding Warnings
Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.
Excreted into human milk: Yes
Comment: Infants should be monitored for drowsiness and developmental milestones.
See also
References for pregnancy information
- "Product Information. Trilafon (perphenazine)." Schering Corporation (2001):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
References for breastfeeding information
- "Product Information. Trilafon (perphenazine)." Schering Corporation (2001):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- United States National Library of Medicine "Toxnet. Toxicology Data Network. http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT" (2013):
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.