Lumateperone for Bipolar Disorder User Reviews

• Sar...
• Taken for 1 to 6 months
• June 17, 2022

"Amazing so far. I have been on it for six weeks and after getting past the first three days taking it- which gave me awful headaches, nausea, dry mouth, and fatigue - I started to feel something in me change. After three weeks I can say I noticed that the typical bad, ruminating thoughts of despair and general negativity were decreasing. And now at six weeks I can honestly say I have days where I catch myself and think, “Wow— I haven’t thought anything bad today”. I have never had a med this effective, and have a very sensitive/resistant system that has made med therapy a chore because nothing ever seems to work, or I end up having bad side effects. For the first time in 25+ years I feel hopeful; I am finding real joy in things, laughing genuinely, and I am able to be more compassionate and realistic with the pressures I put on myself. It’s improving my outlook on life and in turn improving my relationships. This is a miracle med for me."

• Val...
• Taken for 1 to 6 months
• October 26, 2023

"Caplyta has changed my life. For many years, I took other antipsychotics and also tried lithium. They left me with tremors, gaining 75 pounds, suicidally depressed. I have bipolar type 1, sensory integration disorder, ADD, agoraphobia, OCD, and anxiety. On all previous mood stabilizers and antipsychotics, I had a flat mood, no real happiness. But still crushing bouts of depression. Also, I have never been able to keep my house clean. I often hoard. I have issues with keeping up my hygiene. I was full of self-doubts and paralyzed with fear. Just generally waiting to die. I have been tweaking the Caplyta, 42mg, with my other meds - Trintellix 20mg, buspirone 30mg, Rexulti 4mg, and clonazepam 2mg for sleep or as needed. I started taking Caplyta in late May. I felt it really kicked in September. My house is immaculate. I bathe every day. My intrusive thoughts/voices have significantly decreased. I rarely feel suicidal. I can leave my house alone. I have lost weight. I feel amazing!"

• Esb...
• Taken for 1 to 6 months
• March 24, 2023

"Caplyta is a game changer! For me, my bipolar depression is mostly compounded by my ADHD, creating extremely low energy and so much restlessness. Because all other antipsychotics block the D1 dopamine receptor, they never help me beyond pulling me out of an acute hypomanic or mixed episode. Caplyta is a D1 and D2 agonist (promoter)! It has been remarkable for keeping me level and helping with my depression without causing any weight gain whatsoever. Two months on it, and I’ve lost everything I gained and more from when I was on Abilify. Caplyta is my savior. It’s my miracle all-in-one. Please try it, and give it a few weeks."

• Anonymous
• Taken for 1 to 6 months
• February 23, 2022

"Caplyta is my fifth trial antipsychotic, and the first one that has produced no side effects. I have noticed a substantial shift in my depression and mood. It has not completely alleviated all of my symptoms, but it is definitely helping. I take it in combination with Lamictal 300 and Divalproex 250."

• Mau...
• Taken for 1 to 6 months
• August 7, 2024

"This drug has changed my life after failing 14 antidepressants (major classes and atypicals). I have suffered from treatment-resistant bipolar II depression since puberty and was stunned to see that this was only the second drug approved for bipolar II depression next to Seroquel, which turned me into a zombie. Being an antipsychotic, it starts working in days, not weeks or months. I’ve used it for two months. First, I noticed social withdrawal disappear as I became more friendly and outgoing, then noticed the negative thought spirals and intrusive thoughts disappear. Verbal intelligence and executive function seem better. Things like dating, job interviews, and social events became easier. I don’t worry as much about finances or my future or past. The main side effect is morning grogginess. But it gets better. One very important detail: this drug is metabolized by the P450 complex. Do NOT mix with any cannabis products including CBD as you’ll get VERY sick."

• Anonymous
• Taken for less than 1 month
• April 16, 2022

"Here is a weird one. I've been on Caplyta for a week as of today. And I seem to embarrassingly lost bladder control. Yesterday I had 3 accidents and today I have had 3 as well! It hits out of nowhere that I have to go, and if I don't get to a toilet within a minute, I just go uncontrollably on myself. I can't stop it. I'm 32, haven't had a child in nearly 10 years. I don't know what could be causing this other than I've been on a new medicine. I'm so embarrassed. I'm a school bus driver, it happened today at the end of my route before I could make it back to the bus yard, and I soaked myself and the seat of the bus. I was so embarrassed on the walk to my car! Has anyone else had this happen?"

• Bee...
• Taken for 1 to 6 months
• May 23, 2022

"My God, this medication has changed my life. I am able to separate my emotions from my logic. I'm not depressed or angry anymore. Is this what life is like for 'normal people'? I feel like I have hope in my life which I really haven't had before. I have bipolar 2 as well as C-PTSD. I take this alongside Lamictal, Celexa, and Prazosin (for PTSD nightmares). Whoever made this drug is a lifesaver. I've had side effects of dry mouth and felt an improvement within 2 weeks."

• RL8...
• Taken for less than 1 month
• June 10, 2022

"I’m very early into taking this medication. About six days to be exact. I have BP1 disorder, generalized anxiety, and panic disorder. I have been on several different medications over the years. Currently, I take 450mg ER Lithium once in the AM and twice at night. Lamictal (brand name) 100mg once daily and 1mg Xanax 4x daily as needed. Speaking with my psychiatrist about my irritability and flat mood, we decided to give Caplyta a try. I was skeptical because of how new it is, not to mention seemingly bad reviews. That being said, the first night was a bit hairy. I would get unbelievably cold like I was in Antarctica with no clothes on. Then I would be burning up. A brutal headache ensued late and into the next day. I was considering not taking it the next day, but I decided to stick with it. I’m glad I did. The side effects were drastically less the next day and more or less gone completely, and I noticed a difference for sure (i.e., more engaged, better mood)"

• apa...
• Taken for 1 to 6 months
• March 10, 2023

"I've been on Caplyta going on 4 months now. My depression has never been worse, I now have high blood pressure, dystonia, heartbeat irregularities, SEVERE constipation, severe anxiety, and broken sleep, about 10 hours a day. I've never felt this horrible on an antipsychotic med in my life before, and I've been on most of them. I can't get out of bed to shower, do chores, do any self-care, cooking, clean, etc. These drugs' side effects are worse than any drug I've taken for my BP2 depression. I've almost landed in the ER for heart palpitations and high blood pressure and resting heart rate in the high 80s to low 90s. The amount of apathy I have is unlike anything I've experienced. It may work well for schizophrenia, but for my BP2, it is the worst drug I've ever taken in over 32 years. I would never recommend this drug to anyone for BP2 depression."

• Ray...
• Taken for 1 to 6 months
• March 11, 2022

"Caplyta made my depression worse. It was like I was in a black hole for a month. It got rid of my mania for sure. But the crushing depression made it a really bad choice for me. I will never take this again."

• PAP...
• Taken for 1 to 6 months
• January 23, 2025

"Really relieved my depression. I was ready to give up and didn’t think I would be able to stay alive much longer. Caplyta changed my life. It is the first antidepressant that worked, and I have tried many. It does make me sedated and sleepy, but the effects only last about two hours. I usually take it before bed, so by morning I am fine. Initially, I had terrible dry mouth, and my nose would plug up, but after about 45 days, those symptoms went away. I hope this medicine is always available. It is very expensive, but fortunately, my insurance covers most of it. I slowly went from 10 to 20 to 40 mgs."

• Bes...
• Taken for 1 to 2 years
• April 3, 2025

"I have tried several other medications over the last decade. This one is the best experience yet. 42 mg capsules once per day. Nearly no side effects. Some dizziness if I get up too quickly. Depression is 95% gone. Mild mood swings. Mania is present at times but very mild and manageable. I am not currently on any other psych meds."

• Bab...
• Taken for 1 to 6 months
• February 12, 2022

"I’ve been taking Caplyta for almost a month for bipolar depression. I immediately felt better emotionally but have developed a perpetual need to yawn/take a deep breath and a tightness across my upper abdomen. I’ve also noticed tension in the front of my neck and chest. It is not ideal and I am constantly debating these pros and cons. I have more mental clarity than I have had in years, but I am aggravated by yawning or semi-nauseous."

• Man...
• Taken for 1 to 6 months
• August 28, 2023

"I would ignore these negative reviews. They seem to be people who only stayed on the drug for a couple of days. I have bipolar depression. Eleven months ago, I was hit with the worst depression of my life. I couldn't get off my bed or off the couch. I slept a ton. My house was trashed for months. My doctor wanted me to try Caplyta. Now. The first day I took it, it was horrifying. I took it at night and woke up in the middle of the night with the worst throbbing headache I have ever had. ER worthy. I rushed to take an 800mg ibuprofen, and that only cut the pain down in half. A few hours after I went to bed after being awoken by a headache, I woke up in the AM. I felt completely drunk. I couldn't walk straight, bumping into walls, etc. I will tell you, after the first day of taking this med, the next day I had no symptoms. No headache, I did feel a little wobbly, but not as bad as the first day. On the third day, no side effects. The third day is when my depression completely vanished. Amazing."

• Fuh...
• Taken for less than 1 month
• March 17, 2022

"I started this med a couple of days ago. I feel okay. Extreme dry mouth. I literally woke up in the night to chug milk, water, and OJ. That being said, I usually can only sleep 90 minutes each time I fall asleep through the night. I’ve been sleeping 3-5 hours each time the last couple of nights, and for the first time in years, I'm feeling like I’ve had some rest when I awake. For years, crawling out of bed in the morning, I felt like I had the crap beaten out of me. The only side effect I’m worried about is the weight gain. But I will continue to work with my doctor to see if we can make a go of this. I’ve tried many meds over the years. This is the only one I have hope for, as the others made me crazier, made me want to gamble, and one had me so zombified that I was going to Jack in the Box every night for like 200 mini churros."

• eja...
• Taken for 1 to 6 months
• June 17, 2022

"Doctor started me on this new medicine as an adjunct to the other medications I take. It took around 2 weeks to notice any real effects from this drug. Caplyta certainly did lift my mood, but I did have to come off of this drug due to the side effects. This is a relatively new drug, and I don’t think many of the side effects are documented well. I stopped because Caplyta made me lose control of my bladder, and it made me feel like I had to go to the bathroom all the time. This was to the point where I got tested for a UTI (negative). I also got shooting pains in my rib cage near my upper chest. I’m not saying it’s a bad drug, just feel it out and listen to your body."

• 233...
• Taken for less than 1 month
• December 18, 2024

"I have never reviewed a drug before. I have chronic pain and have always also just had the anxiety/depression diagnosis. Now I’m seeing a new psychiatrist, and he said I’m not depressed, I’m bipolar. This was said one week ago for the first time, and I am 41. He wanted me to stop taking the Wellbutrin and the Cymbalta (which weren’t doing anything but I was trying to stay the course) and try Caplyta. Since about April, I have been in bed, and it was getting worse in the last month or so that my exhaustion was so severe that I would do one thing, like grocery shopping, and I was done. The first day on Caplyta, I was woozy, I felt unsteady on my feet, afraid to drive. By Sunday, no side effects whatsoever, and I spent time with friends, went out to lunch, and took the kids clothes shopping. Monday, all day Christmas shopping and wrapping. Today, I went to a friend’s all morning, saved my daughter on stage. I have actually never felt this good and happy. I didn’t know it was possible."

• jsn...
• Taken for 6 months to 1 year
• September 24, 2022

"FYI, there is a lot of you out there expecting Caplyta to start working to relieve your symptoms on day one when the pharma corpos clearly state on their websites that Caplyta begins to work after two weeks but doesn't reach full strength until after six weeks of taking Caplyta. Side effects may start up any day, even on day one, and they can really suck, so call your doctor rather than wait and see if it all fixes itself. I'm on Caplyta, which worked well for me, it changed my life and even saved it as I almost committed suicide before I was stopped by my wife, who talked me out of it. I decided to give meds a try as a last resort. One last try. The Caplyta, lithium, and Lamictal greatly improved my bipolar symptoms as the weeks went by, and eventually, they vanished along with my suicidal urges. My marriage was saved as all of the chaos I caused during my episodes were now just memories of a previous life 1.5 years ago."

• Yol...
• Taken for less than 1 month
• May 20, 2022

"I have been on Caplyta for a week and 2 days. I have been so hopeful for 6 years now that a new medication could help with my depression. I've had a bipolar 1 diagnosis for almost 20 years now. Abilify was life-changing for me. It worked for me all on its own for about 12 years!! But it stopped working. I like to run a little hypomanic, which is where I find myself right now. However, I have also stopped my Wellbutrin and tapered off Abilify all within a week too. The first few days of Caplyta, I was exhausted around the clock. I also have very vivid dreams. The tiredness gets better each day. I haven't experienced anything else physically. I am exercising again, I am writing again, and I am hopeful. So it's definitely working for me so far!"

• tex...
• Taken for 1 to 6 months
• June 29, 2022

"I'm currently on Caplyta 42 mg and have been for over 3 months. It has vastly improved my life and allowed me to get back to a normal version of myself. I've tried several other atypical antipsychotics like Latuda, Vraylar, and Geodon, each with varying success. Vraylar was the best antipsychotic I was on, sadly, it quit working. Caplyta has gotten closer to the stability I had with Vraylar. However, I understand that every person has different success with different medications, so do not compare my experience to others. Caplyta, though, is very expensive, and with my insurance switching in the coming months, I may be forced to switch once again, which I do not want due to the success of Caplyta. I've had no noticeable side effects from this medication, and it does not interact with my other medications prescribed, which is a major advantage."

• be-...
• Taken for 1 to 2 years
• May 2, 2024

"I've been struggling with my mental health for my entire lifetime. Thirty now, and let me tell you it’s a GAME CHANGER. I have always struggled with alcohol. I used it to cope. I would be impulsive, angry, ruin relationships with friends and family. Sleeping all the time, everyday tasks just felt like a huge marathon and exhausting. It was a fight every single day. In my teenage years, I was making decisions that had negative impacts on my future. I was always feeling held back and empty. I was prescribed this about a year ago. At first, it was a little brutal as far as the drowsiness and my headaches were bad. After about a month of sticking with it… I'm now 9 months sober, my job and work ethic have improved so much. The relationships I have with my friends and family are so much better. I'm no longer angry or have any bad thoughts. I'm way more confident in myself. My health habits are much better. Every single aspect of my life has improved. I feel free. 20/10 recommend."

• Tor...
• Taken for 1 to 6 months
• June 19, 2023

"Hang in there and give it at least 3 days. After the 3rd day, for me, I felt less or no side effects at all. I’ve been taking Caplyta for 2 months, and I am very pleased with this. I’ve tried various doses of many other drugs, but this is great stuff. I’m happier, I’m laughing. I’m productive. Stick it out before calling it quits after that first dose."

• PJ6...
• Taken for 6 months to 1 year
• December 23, 2024

"I was diagnosed with bipolar 1, PTSD, and OCD in 1994. Generally, I have had mostly long, depressed episodes. Normally, I rapid cycle. I went on Caplyta 8 months ago. At first, it made me dizzy, sleepy, with an extremely dry mouth. I was able to finally sleep through the night. After about 2 weeks, I felt a lot less depressed. Since then, my mood has drastically improved. I haven’t felt flat on this med. My emotions are more real. When I laugh, it’s natural. There’s nothing forced about it. I can genuinely FEEL again. I’ve noticed feeling my old personality before I started having bipolar symptoms, more compassionate and smarter. My thinking became clearer. I was able to verbally communicate better. I have motivation I haven’t had in years. I can shower, clean my house, and help others. My appetite has decreased, so I have lost 55 lbs. I’m not sure if that’s a good thing or a bad thing yet. Anyway, Caplyta has been wonderful for me. I am ME again."

• jcc...
• Taken for 1 to 6 months
• February 9, 2023

"My doctor recommended Caplyta 10 mg. I have been taking it for two weeks and can barely get out of bed. My hands and feet keep falling asleep, but I can't find that as a side effect anywhere. It's supposed to help with depression, but I feel worse. I keep thinking of sad things and crying, which is weird for me. I'm hot all the time, which is fine for winter but won't be in a few months. This one is not for me. It reminds me of Seroquel without the munchies. The doctor really hyped this one, but I just don't see the appeal."

• DeA...
• Taken for less than 1 month
• May 5, 2022

"Took this on day one for bipolar 2, and 2 hours later I felt like I had icy hot all over my body. Then I felt lethargic to the point I had slurred speech, and I could barely move without help. I had a very dry mouth and excessive thirst. The severe headache started, so I took a nap for about an hour. I woke up with neck pain connecting to the back of my head, nausea, and vomiting. A 2-hour shower eased the headache very little, but it continued along with the nausea until the following day. Also, on the following day I had dark urination. I was advised to discontinue the medication."