Lumateperone for Bipolar Disorder User Reviews (Page 2)

• Catbug
• Taken for less than 1 month
• July 20, 2022

Caplyta (lumateperone) "I have only taken this medication for one night and I'm never taking it again. My body felt like it was on fire, my head was pounding, when I got up, I felt as if I was gonna faint, I was so nauseous and the next morning I felt so confused and dizzy. I had to sit down in the shower because I thought I was gonna pass out and I slept all day because my brain was so foggy."

• whenw...
• Taken for less than 1 month
• July 20, 2022

Caplyta (lumateperone) "Caplyta has made me feel nothing but anger, annoyance, and frustration. I haven’t felt a single positive emotion since starting it. It’s not even a listed side effect. It has made me so angry, so constantly, that I cry every day out of pure anger. Constant, uncontrolled anger every day. No other emotions."

• be-pa...
• Taken for 1 to 2 years
• May 2, 2024

Caplyta (lumateperone) "I've been struggling with my mental health for my entire lifetime. Thirty now, and let me tell you it’s a GAME CHANGER. I have always struggled with alcohol. I used it to cope. I would be impulsive, angry, ruin relationships with friends and family. Sleeping all the time, everyday tasks just felt like a huge marathon and exhausting. It was a fight every single day. In my teenage years, I was making decisions that had negative impacts on my future. I was always feeling held back and empty. I was prescribed this about a year ago. At first, it was a little brutal as far as the drowsiness and my headaches were bad. After about a month of sticking with it… I'm now 9 months sober, my job and work ethic have improved so much. The relationships I have with my friends and family are so much better. I'm no longer angry or have any bad thoughts. I'm way more confident in myself. My health habits are much better. Every single aspect of my life has improved. I feel free. 20/10 recommend."

• nunya
• Taken for less than 1 month
• April 16, 2023

Caplyta (lumateperone) "I only needed to take it once 10.5 mg to know I'd never take it again. Within an hour I was passed out completely and don't remember getting to the bed. Woke up after 4 hours and started having hope for it as I was feeling something shifting, more balanced if you will. Well then came the major headache everyone is talking about, then the burning from the inside out, unable to regulate body temperature, wobbly. Still was wobbly for a couple of days and my nose was so stuffy the next day. I really had hope. Try it for yourself but I would definitely recommend the lowest dose of 10.5 mg."

• Loz
• Taken for less than 1 month
• September 26, 2022

Caplyta (lumateperone) "I have Bipolar 2 and started this for depression. I took the first dose of Caplyta last night, about 24 hours ago now. It was terrible. About 45 minutes in I felt my feet burning and then the burning crept to my torso and back. It was burning so badly that I started looking for blisters! I could not rest as my skin was so inflamed. I was also freezing. I had a comforter and a blanket over me and it’s 74 degrees in my house. By morning I was so groggy and dizzy. The burning finally eased up by mid morning but even now I can still feel a bit of a burn on my arms and hands. I tell you this is a dangerous drug. I will not take another dose, and like someone else said on here, the experience has made me nervous to try other meds."

• Jason
• Taken for 6 months to 1 year
• October 11, 2023

Caplyta (lumateperone) "I was prescribed Caplyta 42mg for Bipolar 1 in a mixed state 10 months ago. The first two weeks involved the side effects of other reviews: POUNDING headaches, nausea, severe confusion, and dry mouth. Within the first three days my depression seemed all but canceled out; it took about a week for the mania to subside. I would say that it definitely does the job effectively. I would like to mention though that no other AP has had such a profoundly weird effect on my psyche. From day 1, it seemed to create an uncanny brain fog so thick that it became very difficult to engage externally, but it enabled CRYSTAL clear internal thinking. This was great for therapy, but also intense rumination! My focus and working memory fell under that 'external' part and became so poor that I'm now tapering away in favor of Latuda. Definitely check in with yourself if you try this one out! Despite the inner turmoil, it made me present normally with limited influence on my affect, so only I could see the issue."

• lex
• Taken for less than 1 month
• May 20, 2022

Caplyta (lumateperone) "Possibly the worst I have ever felt from just one use. First I thought I was being paranoid but like 20 minutes after taking it my arms felt like they were on fire. And then I threw up and then my feet started burning but I was freezing and instantly felt high. It was an extreme high. I then got my mom to come get me because i couldn’t walk from being dizzy and I kept falling. She took me to her house and I instantly had one of the worst headaches I have ever felt in my entire life and started throwing up. Then I checked my temp and my fever was 100 and my heart rate wouldn’t go down and my oxygen level was 93. My feet and hands got swollen too. And I instantly started going in and out of consciousness. I ended up taking a nap and I couldn’t stop sweating with chills and when my bf picked me up he said I kept passing out. i woke up this morning still sick andI went to the doctor this to change my meds."

• Anonymous
• Taken for 1 to 6 months
• October 8, 2022

Caplyta (lumateperone) "I take Caplyta with 300 mg Effexor daily for MDD (Major Depressive Disorder). At first I wasn't sure I wanted to continue the medication, I had terrible dry mouth, nausea, trouble sleeping and dizziness. I'm glad I stayed on it. My depression has greatly improved. I still have low days, but I generally have more energy. Have lost 12 lbs, and no longer have suicidal ideation. My only caveat is I find myself with very high anxiety. I don't know if this is due to the medication or life circumstances. Does anyone else have a lot of anxiety since taking Caplyta?"

• Jde
• Taken for less than 1 month
• August 12, 2022

Caplyta (lumateperone) "This was the worst medicine I’ve ever been on. I took it and one hour later my skin was burning and I was so restless despite taking melatonin. Then I fell asleep and woke up with a massive headache, severe dizziness, and nausea. This lasted all day. I couldn’t make food because of dizziness and not that that mattered because I was so nauseous I had no appetite. As the day progressed it never eased to the point where I had to go to the ER. DO NOT TAKE THIS! Try it for yourself but I’m warning you it’s done it’s damage. I’m now terrified to start new meds."

• Working
• Taken for less than 1 month
• July 30, 2022

Caplyta (lumateperone) "I started July 13, 2022. First dose I woke up feeling like I was a little drunk, enough that I shouldn't have driven. That has gone away. I have frequent urination but this is also waning. My appetite has decreased and I’ve lost almost 9 pounds, which I’ve needed to lose; I hope I lose more! It’s helped me have really deep sleep, I fall asleep fast. It’s helped my depression immensely, I no longer have suicidal ideation and I want to do more things! I’m laughing again and my wit has returned. I’ve noticed a return in my acid reflux, I don’t know if this is because of the medication. My hair isn’t falling out. I think this a great medication and I’m very glad my doc prescribed it to me. I’m excited to see how I’m doing a month in! I take the standard 42 mg. dosage in the evening."

• Mary...
• Taken for 1 to 6 months
• May 28, 2022

Caplyta (lumateperone) "I was on lamictal and gabapentin successfully for years then last year started having increased anxiety and panic attacks with routine activities so had to change meds. After a less than satisfactory experience with Vraylar—it kept me from suicide so I continued it but the tardive dyskinesia was very uncomfortable and left me with a persistent repetitive movement problem—I started Caplyta as soon as it was approved for bipolar. My mood is stable now and the anxiety and panic I was having have almost completely gone away. I also don’t have to take lunesta for sleep anymore because the insomnia I had for 10 years is gone. One problem I've had is that I wet myself in my sleep if I become intoxicated. My provider said he thought that the CNS depression is so profound that it caused that when alcohol was added to the mix. Thank goodness I didn’t stop breathing. Needless to say I don’t get intoxicated anymore and it doesn’t happen."

• Oklah...
• Taken for 1 to 6 months
• May 16, 2022

Caplyta (lumateperone) "I find Caplyta to be ineffective. I’ve become very drowsy and have massively increased appetite. For the prescribed purpose, I see no effects. Feels like I’m taking a placebo. This drug is also massively expensive."

• Anonymous
• Taken for 1 to 2 years
• June 20, 2023

Caplyta (lumateperone) "For me it was a miracle drug. Absolutely zero side effects. They told me that it would make me sleepy but I didn’t experience that. It has kept my thoughts clear and I don’t feel drugged up all the time."

• Diane
• Taken for less than 1 month
• May 13, 2023

Caplyta (lumateperone) "I started Caplyta on April 16 2023 at 10.5 mg. On April 21 I started 21 mg. On April 24 I started 31.5 mg. On April 29th I started 42 mg. I am so severely depressed. Having headaches, coughing, sneezing, a raw nervous stomach, and diarrhea. Don’t know how I am going to continue feeling this way. Suicide ideations are very scary. Is there still hope for me? I can’t decide if I should continue on this medication or not. Not sure how much more misery I can take. I have also considered going back down to 31.5 mg maybe 42 mg is too much for my system. I just need some relief from this depression. I wake up every day not wanting to do another day. I am Bipolar 2 depression. I usually feel good for about 15-19 days of feeling normal and then I tank for 28-25 days. I have been deeply depressed since April 14. I am barely surviving right now. Does anyone have any helpful advice for me?"

• Anonymous
• Taken for 1 to 6 months
• November 17, 2022

Caplyta (lumateperone) "I started Caplyta because I was sick of the weight gain, flat affect, and sedation that I was getting from other antipsychotics. The first two weeks were physically rough. I was waking up after 5 hours of sleep every night, I was incontinent of stool 3x, and I was incredibly nauseous with no appetite to the point where I'd go 5 days without eating. Then, after 2-2.5 weeks, something changed. All the side effects went away and I was finally able to focus on how it made me feel mentally. It has changed my life. My family says I have a completely different personality - one that is engaged in life, confident, calm, social beyond belief, and genuinely happy. I have had no psychosis, and I feel like Caplyta pulled me out of a depression that I had just unconsciously accepted as my "normal". I'm very happy I found this drug and will continue to use it. FYI, I know it's expensive, but if you don't have insurance GoodRx does a great job providing coverage for this medication."

• Dbond...
• Taken for 1 to 2 years
• April 12, 2024

Caplyta (lumateperone) "I've been taking Caplyta for almost 1 1/2 years. The first day I had a headache, but I read reviews first so I was prepared for it. It went away, the darkness and the negative thoughts started to disappear within a week! I feel Abilify contributed to the darkness, honestly. I will also say I had issues with my bladder as well (more than a few accidents), but I will say to those of you with similar side effects, the bladder control got better after a while so that's not an issue anymore. I take it at night and I do feel like I sleep better at night (especially in comparison to when I forget to take it). No allergic reactions like burning and freezing, so I'm very fortunate. I initially lost about 6 pounds on it, but I have continued to gain again. I'm only taking Caplyta."

• tery
• Taken for less than 1 month
• May 26, 2023

Caplyta (lumateperone) "This is a BIG no for me. I took ONE capsule and literally could barely walk I was so tired. Then I woke up with the biggest headache. I couldn't even fathom having to go through a few days of this let alone possibly weeks."

• Your...
• Taken for 1 to 6 months
• August 27, 2022

Caplyta (lumateperone) "I have a very severe case of bipolar II, I have been on almost every single mood stabilizer, antidepressant, and antipsychotic known to man.. This one did not help me at all. The first week I was very sick (migraine, nausea, stomach pain, heat regulation) but nothing I couldn't push through. After about day 10 something changed in my brain that sent me into a 20 day long manic episode with minor psychosis. Nearly hospitalized when I came off the medication due to withdrawal effects. Not the worst medication I've taken but it's definitely in the top 3"

• raaatz
• Taken for 1 to 6 months
• February 4, 2023

Caplyta (lumateperone) "This medicine changed my life. I’m diagnosed with bipolar and have been in a depressed mood for 2 years. I have been taking caplyta for a month and I haven’t felt this good since I was a child. I luckily have not experienced any of the bad reactions others have mentioned in reviews. The first night I took it I just felt very vulnerable and reality seemed a little shifted, but it wasn’t bad. Positive effects kicked in within a week and I just keep feeling better and better. I slept more than 12 hours before this medication and had absolutely no energy throughout the day. I now have sustained energy and get a healthy 8 hours of sleep. I have developed a good routine and have stuck to it. After 3 weeks, I realized I was able to feel true joy and I laugh more. I enjoy being around others. I have more depth and more clarity. I am able to take it easy and not stress/focus on the bad. I hope this medication continues to work."

• Caplyta
• Taken for 6 months to 1 year
• July 29, 2023

Caplyta (lumateperone) "I love it! When I was first diagnosed with type II bipolar, they put me on 50mg of Lamictal. This was a devil drug for me. It absolutely did the opposite of what it should have and induced more manic episodes than ever. I was flying off the handle at the slightest inconvenience. When I told my psychiatrist, she upped my dosage to 100mg and I began taking 21mg of Caplyta with it. Not much changed with the increase of Lamictal, so I weaned off of it and started taking 42mg of Caplyta alone. (Also, since I've been off of Lamictal, I've had horrific hand and leg tremors - which is known to be associated with quitting it - that drug is HELL!) But since switching over to Caplyta, I feel absolutely great. I'm finally able to feel like myself again. I'm finally happy for the first time in a really long time. I don't have any side effects either - no weight gain, headaches, moodiness, nothing! It's like a complete 180 and I'm beyond thankful for this medication."

• Saraa...
• Taken for less than 1 month
• January 7, 2023

Caplyta (lumateperone) "(Prescribed for bipolar II) This was the worst experience I’ve ever had with any prescription ever and I only took one pill. In common with other antipsychotics I’ve taken in the past, it made me so lethargic I practically felt drunk. But what was so concerning I actually called the doctors after hours was that I felt unbelievably chilled to the bone (and I’m usually always hot). I was in bed freezing despite wearing 4 blankets, warm fuzzy socks, slippers, pants, 2 sweatshirts, and a beanie. Before the “drunk” feeling kicked in, I had to drive my son to work up the street and I was blasting my heat in the car at 86 degrees! My skin began to burn badly. I can’t explain better than it being like on the verge of frostbite but was warm to the touch on the outside. My feet were and still are the worse. It’s been 8 hours since I took the meds and I’m not too cold anymore but my feet have felt like they’re on fire so bad I’d love to go stick them bare in the snow."

• Hrhmi...
• Taken for less than 1 month
• September 21, 2022

Caplyta (lumateperone) "This is a VERY specialized medication. It’s changing everything for me personally. I work in healthcare & have been on the med merry-go-round for a minimum of 15 years. Diagnosis of MDD, PTSD, Anxiety/panic attacks, & bipolar II. While, obviously, if you are having any life threatening side effects, I highly suggest sticking it out for at least a week. Yes, I had the extremely dry mouth, felt drunk in the AM, dizzy, severely tired for the first 5 days. Then things picked up significantly, to the point where I was afraid I may be experiencing hypo mania. Immediately spoke with my psychiatrist (knows me well, 6+ years) & after explaining my feelings/actions she said that it doesn’t sound like hypomania at all & that, most likely, I am actually feeling happiness for the first time. I have just hit the 2 week mark & am still all over the place as far as sleepy or not, hungry/mildly nauseous, overall; I’m not depressed. TBD but feeling better"

• Anonymous
• Taken for less than 1 month
• January 16, 2023

Caplyta (lumateperone) "I had a terrible experience with this drug. I only took it once, but within 15 minutes, I began to have a freezing sensation on one arm, then the other. My nose became stuffed up and I couldn't breathe. I couldn't fall asleep. After an hour, I fell asleep, but the next day I was the sickest I had ever been. I couldn't get out of bed and couldn't eat. The freezing sensation was in different places all over the upper half of my body. By 5 pm I was mostly better but the freezing feeling has never gone away. It's been a year. Sometimes it's in my head so bad I can't drive or work. This has been a terrible experience."

• Anonymous
• Taken for less than 1 month
• August 2, 2022

Caplyta (lumateperone) "I've been on it for 5 days and it is awful!! My mood isn't better. I can't do anything. I feel like crap! My head hurts, my neck is all tensed up constantly, my stomach feels like it's in knots, I don't want to drink anything I have to force myself to drink, I pee every 5 min & I feel like I have a UTI, I just want to sleep, but I can't sleep soundly. It's the worst feeling! I want to just stop taking it, but I'm afraid of what will happen."

• Lala
• Taken for less than 1 month
• September 18, 2022

Caplyta (lumateperone) "Took 1 pill (low dose to start) in the evening. I don't remember if I took it with food. 1 hour later, my hands and feet started feeling a burning sensation as if I was putting them under an hot heat lamp. No degree of cold (cold water, ice water, ice) helped with the intensity of the feeling of burning. My hands and feet were red but at a regular temperature to the touch. I was eventually able to go to sleep and the burning sensation stopped by the next morning. With that side effect, I did not take another dose. After reading many other people's reviews, I found only .one person who had a similar reaction. It must be very rare. Most reviews I read were very positive. Wish mine had been too. I also contacted the company that makes Caplyta to inform them of the side effect."