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Nonsteroidal anti-inflammatory agents

Other names: NSAIDs

What are Nonsteroidal anti-inflammatory agents

Nonsteroidal anti-inflammatory agents (usually abbreviated to NSAIDs) are a group of medicines that have anti-inflammatory (reduce inflammation), analgesic (relieve pain) and antipyretic (lower temperature) effects.

Although different NSAIDs have different structures, they all work by blocking cyclo-oxygenase (COX) enzymes. There are two main types of COX enzymes: COX-1 and COX-2. Both types produce prostaglandins; however, the main function of COX-1 enzymes is to produce baseline levels of prostaglandins that activate platelets and protect the lining of the gastrointestinal tract, whereas COX-2 enzymes are responsible for releasing prostaglandins after infection or injury. Prostaglandins have a number of different effects, one of which is to regulate inflammation.

Most NSAIDs inhibit both enzymes, although a few are available that mainly inhibit COX-2. The pain-relieving and anti-inflammatory effects of NSAIDs are mainly due to inhibition of COX-2, and their unwanted side effects are largely due to inhibition of COX-1.

List of Nonsteroidal anti-inflammatory agents:

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Drug Name DownUp( View by: Brand | Generic ) Reviews Ratings DownUp
ketoprofen systemic (Pro, More...)
21 reviews
   
9.2
fenoprofen systemic (Pro, More...)
2 reviews
   
8.7
tolmetin systemic (Pro, More...)
2 reviews
   
8.5
sulindac systemic (Pro, More...)
18 reviews
   
8.2
indomethacin systemic (Pro, More...)
139 reviews
   
8.0
diclofenac / misoprostol systemic (Pro, More...)
42 reviews
   
7.9
piroxicam systemic (Pro, More...)
23 reviews
   
7.9
diclofenac systemic (Pro, More...)
380 reviews
   
7.7
etodolac systemic (Pro, More...)
56 reviews
   
7.6
esomeprazole / naproxen systemic (Pro, More...)
24 reviews
   
7.4
ibuprofen systemic (Pro, More...)
106 reviews
   
7.4
ketorolac systemic (Pro, More...)
225 reviews
   
7.3
flurbiprofen systemic (Pro, More...)
8 reviews
   
7.2
naproxen systemic (Pro, More...)
396 reviews
   
7.0
meloxicam systemic (Pro, More...)
323 reviews
   
6.9
famotidine / ibuprofen systemic (Pro, More...)
16 reviews
   
6.8
mefenamic acid systemic (Pro, More...)
38 reviews
   
6.4
oxaprozin systemic (Pro, More...)
7 reviews
   
6.4
nabumetone systemic (Pro, More...)
53 reviews
   
6.2
bromfenac systemic (More...)
0 reviews
   
0.0
lansoprazole / naproxen systemic (More...)
0 reviews
   
0.0
meclofenamate systemic (Pro, More...)
0 reviews
   
0.0
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