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Nonsteroidal anti-inflammatory agents

Other names: NSAIDs

What are Nonsteroidal anti-inflammatory agents

Nonsteroidal anti-inflammatory agents (usually abbreviated to NSAIDs) are a group of medicines that have anti-inflammatory (reduce inflammation), analgesic (relieve pain) and antipyretic (lower temperature) effects.

Although different NSAIDs have different structures, they all work by blocking cyclo-oxygenase (COX) enzymes. There are two main types of COX enzymes: COX-1 and COX-2. Both types produce prostaglandins; however, the main function of COX-1 enzymes is to produce baseline levels of prostaglandins that activate platelets and protect the lining of the gastrointestinal tract, whereas COX-2 enzymes are responsible for releasing prostaglandins after infection or injury. Prostaglandins have a number of different effects, one of which is to regulate inflammation.

Most NSAIDs inhibit both enzymes, although a few are available that mainly inhibit COX-2. The pain-relieving and anti-inflammatory effects of NSAIDs are mainly due to inhibition of COX-2, and their unwanted side effects are largely due to inhibition of COX-1.

List of Nonsteroidal anti-inflammatory agents:

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Drug NameView by: Brand | Generic Reviews Avg. Ratings
ketoprofen systemic (Pro, More...)
21 reviews
   
9.2
fenoprofen systemic (Pro, More...)
2 reviews
   
8.7
tolmetin systemic (Pro, More...)
2 reviews
   
8.5
sulindac systemic (Pro, More...)
18 reviews
   
8.2
diclofenac / misoprostol systemic (Pro, More...)
45 reviews
   
8.0
indomethacin systemic (Pro, More...)
144 reviews
   
8.0
piroxicam systemic (Pro, More...)
24 reviews
   
7.9
diclofenac systemic (Pro, More...)
402 reviews
   
7.7
etodolac systemic (Pro, More...)
59 reviews
   
7.6
esomeprazole / naproxen systemic (Pro, More...)
27 reviews
   
7.5
ibuprofen systemic (Pro, More...)
114 reviews
   
7.5
ketorolac systemic (Pro, More...)
242 reviews
   
7.3
diflunisal systemic (Pro, More...)
7 reviews
   
7.2
flurbiprofen systemic (Pro, More...)
8 reviews
   
7.2
meloxicam systemic (Pro, More...)
346 reviews
   
6.9
naproxen systemic (Pro, More...)
423 reviews
   
6.9
famotidine / ibuprofen systemic (Pro, More...)
19 reviews
   
6.8
oxaprozin systemic (Pro, More...)
7 reviews
   
6.4
mefenamic acid systemic (Pro, More...)
39 reviews
   
6.2
nabumetone systemic (Pro, More...)
58 reviews
   
6.1
bromfenac systemic (More...)
0 reviewsAdd rating
meclofenamate systemic (Pro, More...)
0 reviewsAdd rating
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