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Nonsteroidal anti-inflammatory agents

Other names: NSAIDs

What are Nonsteroidal anti-inflammatory agents

All nonsteroidal anti-inflammatory agents (NSAIDs) differ in structure but they all have similar antipyretic, anti-inflammatory and analgesic properties. NSAIDs work by blocking the cyclo-oxygenase (COX) enzyme, so inhibit production of prostaglandins and thromboxanes, which are produced as part of the inflammatory response. There are two types of COX enzymes, COX-1 and COX-2. COX-1 is expressed in most tissues, including platelets. COX-2 is induced in inflammatory cells when they are activated and the primary inflammatory cytokines (interleukin-1 and tumor necrosis factor alpha). COX-2 enzyme is responsible for production of mediators of inflammation. Most NSAIDs are inhibitors of both isoenzymes. The anti-inflammatory action of NSAIDs is mainly due to inhibition of COX-2, and their unwanted side effects are largely due to inhibition of COX-1. There can be considerable variation in individual patient response and tolerance to different NSAIDs.

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

All nonsteroidal anti-inflammatory agents (NSAIDs) differ in structure but they all have similar antipyretic, anti-inflammatory and analgesic properties.

NSAIDs work by blocking the cyclo-oxygenase (COX) enzyme, so inhibit production of prostaglandins and thromboxanes, which are produced as part of the inflammatory response.

There are two types of COX enzymes, COX-1 and COX-2. COX-1 is expressed in most tissues, including platelets. COX-2 is induced in inflammatory cells when they are activated and the primary inflammatory cytokines (interleukin-1 and tumor necrosis factor alpha). COX-2 enzyme is responsible for production of mediators of inflammation. Most NSAIDs are inhibitors of both isoenzymes. The anti-inflammatory action of NSAIDs is mainly due to inhibition of COX-2, and their unwanted side effects are largely due to inhibition of COX-1.

There can be considerable variation in individual patient response and tolerance to different NSAIDs.

List of Nonsteroidal anti-inflammatory agents:

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Drug Name DownUp( View by: Brand | Generic ) Reviews Ratings DownUp
ketoprofen systemic (Pro, More...)
21 reviews
   
9.2
fenoprofen systemic (Pro, More...)
2 reviews
   
8.7
sulindac systemic (Pro, More...)
16 reviews
   
8.5
tolmetin systemic (Pro, More...)
2 reviews
   
8.5
indomethacin systemic (Pro, More...)
130 reviews
   
8.0
diclofenac / misoprostol systemic (Pro, More...)
41 reviews
   
7.9
piroxicam systemic (Pro, More...)
21 reviews
   
7.9
diclofenac systemic (Pro, More...)
353 reviews
   
7.7
etodolac systemic (Pro, More...)
52 reviews
   
7.5
esomeprazole / naproxen systemic (Pro, More...)
21 reviews
   
7.4
ibuprofen systemic (Pro, More...)
97 reviews
   
7.4
ketorolac systemic (Pro, More...)
213 reviews
   
7.3
flurbiprofen systemic (Pro, More...)
8 reviews
   
7.2
meloxicam systemic (Pro, More...)
293 reviews
   
7.0
naproxen systemic (Pro, More...)
377 reviews
   
7.0
nabumetone systemic (Pro, More...)
50 reviews
   
6.4
oxaprozin systemic (Pro, More...)
7 reviews
   
6.4
mefenamic acid systemic (Pro, More...)
35 reviews
   
6.3
famotidine / ibuprofen systemic (Pro, More...)
12 reviews
   
6.1
bromfenac systemic (More...)
0 reviews
   
0.0
lansoprazole / naproxen systemic (More...)
0 reviews
   
0.0
meclofenamate systemic (Pro, More...)
0 reviews
   
0.0
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