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Nonsteroidal anti-inflammatory agents

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

All nonsteroidal anti-inflammatory agents (NSAIDs) differ in structure but they all have similar antipyretic, anti-inflammatory and analgesic properties.

NSAIDs work by blocking the cyclo-oxygenase (COX) enzyme, so inhibit production of prostaglandins and thromboxanes, which are produced as part of the inflammatory response.

There are two types of COX enzymes, COX-1 and COX-2. COX-1 is expressed in most tissues, including platelets. COX-2 is induced in inflammatory cells when they are activated and the primary inflammatory cytokines (interleukin-1 and tumor necrosis factor alpha). COX-2 enzyme is responsible for production of mediators of inflammation. Most NSAIDs are inhibitors of both isoenzymes. The anti-inflammatory action of NSAIDs is mainly due to inhibition of COX-2, and their unwanted side effects are largely due to inhibition of COX-1.

There can be considerable variation in individual patient response and tolerance to different NSAIDs.

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Drug Name DownUp( View by: Brand | Generic ) Reviews Ratings DownUp
ketoprofen systemic (Pro, More...)
17 reviews
   
9.1
fenoprofen systemic (Pro, More...)
2 reviews
   
8.7
sulindac systemic (Pro, More...)
16 reviews
   
8.5
tolmetin systemic (Pro, More...)
2 reviews
   
8.5
piroxicam systemic (Pro, More...)
20 reviews
   
8.2
indomethacin systemic (Pro, More...)
121 reviews
   
8.1
diclofenac / misoprostol systemic (Pro, More...)
38 reviews
   
7.8
diclofenac systemic (Pro, More...)
332 reviews
   
7.8
esomeprazole / naproxen systemic (Pro, More...)
16 reviews
   
7.5
etodolac systemic (Pro, More...)
50 reviews
   
7.5
ibuprofen systemic (Pro, More...)
91 reviews
   
7.4
ketorolac systemic (Pro, More...)
193 reviews
   
7.4
meloxicam systemic (Pro, More...)
266 reviews
   
7.2
naproxen systemic (Pro, More...)
354 reviews
   
7.0
flurbiprofen systemic (Pro, More...)
7 reviews
   
6.9
mefenamic acid systemic (Pro, More...)
33 reviews
   
6.6
nabumetone systemic (Pro, More...)
46 reviews
   
6.5
oxaprozin systemic (Pro, More...)
7 reviews
   
6.4
famotidine / ibuprofen systemic (Pro, More...)
11 reviews
   
6.3
bromfenac systemic (More...)
0 reviews
   
0.0
lansoprazole / naproxen systemic (More...)
0 reviews
   
0.0
meclofenamate systemic (Pro, More...)
0 reviews
   
0.0
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