Skip to Content

Midol Extended Relief

Generic Name: naproxen (na PROX en)
Brand Name: Aleve, Anaprox-DS, Flanax Pain Reliever, Midol Extended Relief, Naprelan 500, Naprosyn

Medically reviewed by Drugs.com on Aug 13, 2019 – Written by Cerner Multum

What is Midol Extended Relief?

Midol Extended Relief is a nonsteroidal anti-inflammatory drug (NSAID).

Midol Extended Relief is used to treat pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps.

The delayed-release or extended-release tablets are slower-acting forms of naproxen that are used only for treating chronic conditions such as arthritis or ankylosing spondylitis. These forms of naproxen will not work fast enough to treat acute pain.

Midol Extended Relief may also be used for purposes not listed in this medication guide.

Important Information

Midol Extended Relief can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use Midol Extended Relief just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Midol Extended Relief may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.

Before taking this medicine

Midol Extended Relief can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Midol Extended Relief may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.

You should not use Midol Extended Relief if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Midol Extended Relief should not be given to a child younger than 12 years old.

Ask a doctor or pharmacist if this medicine is safe to use if you have:

Taking Midol Extended Relief during the last 3 months of pregnancy may harm the unborn baby. Ask a doctor before using this medicine if you are pregnant. This medicine may interfere with ovulation, causing temporary infertility.

You should not breastfeed while using this medicine.

How should I take Midol Extended Relief?

Use exactly as directed on the label, or as prescribed by your doctor. Use the lowest dose that is effective in treating your condition.

Do not crush, chew, or break a Midol Extended Relief tablet. Swallow it whole.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Always follow directions on the medicine label about giving Midol Extended Relief to a child. Midol Extended Relief doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight.

If you use Midol Extended Relief long-term, you may need frequent medical tests.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Midol Extended Relief.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Since Midol Extended Relief is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Midol Extended Relief?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking aspirin while you are taking Midol Extended Relief.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to Midol Extended Relief (such as aspirin, ibuprofen, or ketoprofen).

Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb Midol Extended Relief.

Midol Extended Relief side effects

Get emergency medical help if you have signs of an allergic reaction (runny or stuffy nose, wheezing or trouble breathing, hives, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, feeling short of breath.

Stop using Midol Extended Relief and call your doctor at once if you have:

  • shortness of breath (even with mild exertion);

  • swelling or rapid weight gain;

  • the first sign of any skin rash or blister, no matter how mild;

  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • liver problems--nausea, upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • kidney problems--little or no urination, painful urination, swelling in your feet or ankles; or

  • low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Midol Extended Relief?

Ask your doctor before using Midol Extended Relief if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.

Ask a doctor or pharmacist before using Midol Extended Relief with any other medications, especially:

This list is not complete. Other drugs may affect Midol Extended Relief, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Related questions

Hide