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Medications for Temporomandibular Joint Disorder

Other names: TMD; TMJ; TMJ Disorder; TMJ syndrome; TMJD

Temporomandibular Joint Disorder (TMJ) is pain and swelling of the jaw joints. TMJ is usually caused by teeth grinding and tight jaw muscles due to stress. TMJ may also be caused by injury to the jaw, poorly fitting dentures, and arthritis.

Drugs used to treat Temporomandibular Joint Disorder

The following list of medications are in some way related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
cyclobenzaprine Off-label 6.6 18 reviews for cyclobenzaprine to treat Temporomandibular Joint Disorder
Rx B N X
Generic name:
cyclobenzaprine systemic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
diazepam Off-label 9.6 12 reviews for diazepam to treat Temporomandibular Joint Disorder
Rx D 4 X
Generic name:
diazepam systemic
Brand name:
Valium
Drug class:
benzodiazepines, benzodiazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
baclofen Off-label 7.0 9 reviews for baclofen to treat Temporomandibular Joint Disorder
Rx C N X
Generic name:
baclofen systemic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
ibuprofen 8.0 1 review for ibuprofen to treat Temporomandibular Joint Disorder
Rx/OTC C N X
Generic name:
ibuprofen systemic
Brand names:
Advil, Proprinal, Addaprin, Genpril, Midol IB, Motrin, Motrin IB, Nuprin, A-G Profen, IBU-200
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
clonazepam Off-label 9.0 7 reviews for clonazepam to treat Temporomandibular Joint Disorder
Rx D 4 X
Generic name:
clonazepam systemic
Drug class:
benzodiazepines, benzodiazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Valium Off-label 9.6 10 reviews for Valium to treat Temporomandibular Joint Disorder
Rx D 4 X
Generic name:
diazepam systemic
Drug class:
benzodiazepines, benzodiazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
Advil Rate Add review
Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
piroxicam 6.5 4 reviews for piroxicam to treat Temporomandibular Joint Disorder
Rx C N X
Generic name:
piroxicam systemic
Brand name:
Feldene
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Proprinal Rate Add review
Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Addaprin Rate Add review
Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Genpril Rate Add review
Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Midol IB Rate Add review
Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Motrin Rate Add review
Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Motrin IB Rate Add review
Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Nuprin Rate Add review
Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
A-G Profen Rate Add review
Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
IBU-200 Rate Add review
Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Feldene 5.0 1 review for Feldene to treat Temporomandibular Joint Disorder
Rx C N X
Generic name:
piroxicam systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information

Frequently asked questions

View more FAQ

Learn more about Temporomandibular Joint Disorder

Care guides

Medicine.com guides (external)

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.