Generic Name: oxaprozin (ox a PROE zin)
Brand Name: Daypro
Medically reviewed on September 14, 2017
What is oxaprozin?
Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID). Oxaprozin works by reducing hormones that cause inflammation and pain in the body.
Oxaprozin is used to treat pain or inflammation caused by osteoarthritis or rheumatoid arthritis in adults. Oxaprozin is also used to treat rheumatoid arthritis in children who are at least 6 years old.
Oxaprozin may also be used for purposes not listed in this medication guide.
Oxaprozin can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Oxaprozin may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using oxaprozin, especially in older adults. You should not take this medicine if you already have bleeding in your stomach or intestines.
Before taking this medicine
Oxaprozin can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.
Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Oxaprozin may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using oxaprozin, especially in older adults.
You should not use oxaprozin if you are allergic to it, or if you have:
active bleeding in your stomach or intestines; or
To make sure oxaprozin is safe for you, tell your doctor if you have:
a history of heart attack, stroke, or blood clot;
a history of stomach ulcers or bleeding;
liver or kidney disease; or
Taking oxaprozin during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether oxaprozin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Oxaprozin is not approved for use by anyone younger than 6 years old.
How should I take oxaprozin?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.
If a child is using this medicine, tell your doctor if the child has any changes in weight. Oxaprozin doses are based on weight in children, and any changes may affect your child's dose.
If you use this medicine long-term, you may need frequent medical tests.
Store oxaprozin at room temperature, away from moisture, heat, and light. Keep the bottle tightly closed when not in use.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking oxaprozin?
Avoid drinking alcohol. It may increase your risk of stomach bleeding.
Avoid taking aspirin while you are taking oxaprozin.
Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to oxaprozin. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.
Avoid exposure to sunlight or tanning beds. Oxaprozin can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Oxaprozin side effects
Get emergency medical help if you have signs of an allergic reaction: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.
Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.
Stop using oxaprozin and call your doctor at once if you have:
shortness of breath (even with mild exertion);
swelling or rapid weight gain;
the first sign of any skin rash, no matter how mild;
signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
kidney problems--little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;
low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
sleep problems (insomnia);
swelling, urination problems;
itching, skin rash; or
ringing in your ears.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect oxaprozin?
Ask your doctor before using oxaprozin if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.
Tell your doctor about all your current medicines and any you start or stop using, especially:
heart or blood pressure medication, including a diuretic or "water pill"; or
steroid medicine (such as prednisone).
This list is not complete. Other drugs may interact with oxaprozin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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More about oxaprozin
- Oxaprozin Side Effects
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- Drug class: Nonsteroidal anti-inflammatory drugs
Other brands: Daypro