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Famotidine and ibuprofen

Generic Name: famotidine and ibuprofen (fam OH ti deen and EYE bue PROE fen)
Brand Name: Duexis

Medically reviewed on Jul 31, 2017

What is famotidine and ibuprofen?

See also: Kevzara

Famotidine is a histamine blocker. Famotidine works by decreasing the amount of acid the stomach produces.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Famotidine and ibuprofen is a combination drug. Ibuprofen treats the symptoms of arthritis. Famotidine helps reduce the risk of ulcers in the stomach or intestines that can be caused by long-term use of ibuprofen.

Famotidine and ibuprofen may also be used for purposes not listed in this medication guide.

Important Information

Ibuprofen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use famotidine and ibuprofen just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using famotidine and ibuprofen, especially in older adults.

Before taking this medicine

You should not use this medicine if you are allergic to famotidine or ibuprofen, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Ibuprofen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.

Do not use famotidine and ibuprofen just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using famotidine and ibuprofen, especially in older adults.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

  • heart disease, high blood pressure;

  • a stomach or intestinal disorder;

  • liver or kidney disease;

  • a bleeding or blood clotting disorder;

  • asthma; or

  • if you smoke or drink alcohol.

Taking ibuprofen during the last 3 months of pregnancy may harm the unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.

It is not known whether famotidine and ibuprofen passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

Do not give this medicine to a child without the advice of a doctor.

How should I take famotidine and ibuprofen?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.

Famotidine and ibuprofen is usually taken 3 times each day. Follow your doctor's instructions.

Do not take more than your recommended dose. An ibuprofen overdose can damage your stomach or intestines. The maximum amount of ibuprofen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount of famotidine and ibuprofen needed to get relief from your pain, swelling, or fever.

Do not crush, chew, or break a famotidine and ibuprofen tablet. Swallow it whole.

If you use famotidine and ibuprofen long-term, you may need frequent medical tests.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking famotidine and ibuprofen?

Avoid using other medications that contain ibuprofen.

Ask a doctor or pharmacist before using any other cold, allergy, or pain medicine. Ibuprofen and other NSAIDs are contained in many combination medicines. Taking certain products together can cause you to get too much ibuprofen. Check the label to see if a medicine contains ibuprofen or similar NSAIDs (aspirin, naproxen, ketoprofen).

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Famotidine and ibuprofen side effects

Get emergency medical help if you have signs of an allergic reaction: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Stop using ibuprofen and call your doctor at once if you have:

  • changes in your vision;

  • shortness of breath (even with mild exertion);

  • swelling in your hands or feet, rapid weight gain, feeling tired or short of breath;

  • severe headache with neck stiffness, chills, and/or seizure (convulsions);

  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • liver problems--nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or

  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Famotidine and ibuprofen dosing information

Usual Adult Dose for Osteoarthritis:

Famotidine 26.6 mg-Ibuprofen 800 mg (1 tablet) orally 3 times a day

Uses: For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis; and to decrease the risk of developing upper gastrointestinal ulcers, including gastric and/or duodenal ulcer in patients taking ibuprofen for those indications

Usual Adult Dose for Rheumatoid Arthritis:

Famotidine 26.6 mg-Ibuprofen 800 mg (1 tablet) orally 3 times a day

Uses: For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis; and to decrease the risk of developing upper gastrointestinal ulcers, including gastric and/or duodenal ulcer in patients taking ibuprofen for those indications

What other drugs will affect famotidine and ibuprofen?

Ask your doctor before taking famotidine and ibuprofen if you take a blood thinner (warfarin, Coumadin), or an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Ask a doctor or pharmacist if it is safe for you to use famotidine and ibuprofen if you take other medications.

Many drugs can interact with famotidine and ibuprofen. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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