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Famotidine / ibuprofen Side Effects

For the Consumer

Applies to famotidine / ibuprofen: oral tablet

Along with its needed effects, famotidine / ibuprofen may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking famotidine / ibuprofen:

Less common
  • Bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or black, tarry stools
  • blurred vision
  • chills
  • clay-colored stools
  • cloudy urine
  • constipation
  • cough
  • dark-colored urine
  • diarrhea
  • difficult, burning, or painful urination
  • dizziness
  • fever
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • general feeling of tiredness or weakness
  • headache
  • heartburn
  • indigestion
  • itching or rash
  • joint pain
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • nausea
  • nervousness
  • pale skin
  • pounding in the ears
  • rapid weight gain
  • runny nose
  • severe stomach pain
  • shivering
  • slow or fast heartbeat
  • sore throat
  • stomach pain, continuing
  • stomach pain, cramping, or burning
  • sweating
  • tingling of the hands or feet
  • trouble sleeping
  • troubled breathing with exertion
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting
  • vomiting of blood or material that looks like coffee grounds
  • yellow eyes or skin
Incidence not known
  • Blistering, peeling, or loosening of the skin
  • change in consciousness
  • confusion as to time, place, or person
  • cracks in the skin
  • darkening of the skin
  • depression
  • dry mouth
  • fainting
  • hallucinations
  • holding false beliefs that cannot be changed by fact
  • loss of consciousness
  • loss of heat from the body
  • pain in the lower back or side
  • pain in the chest, groin, or legs, especially calves of the legs
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red, swollen skin
  • scaly skin
  • seizures
  • severe headaches of sudden onset
  • sores, ulcers, or white spots in the mouth or on the lips
  • stiff neck or back
  • sudden loss of coordination
  • sudden onset of shortness of breath for no apparent reason
  • sudden onset of slurred speech
  • sudden vision changes
  • thirst
  • unusual excitement, nervousness, or restlessness

Some side effects of famotidine / ibuprofen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Back pain
  • belching
  • body aches or pain
  • cough producing mucus
  • difficulty having a bowel movement
  • difficulty with moving
  • ear congestion
  • loss of voice
  • muscle stiffness
  • pain or tenderness around the eyes and cheekbones
  • sneezing
  • stuffy nose

For Healthcare Professionals

Applies to famotidine / ibuprofen: oral tablet

General

Famotidine-Ibuprofen:
The most frequently reported side effects included nausea, diarrhea, constipation, upper abdominal pain, and headache.[Ref]

Gastrointestinal

Famotidine-Ibuprofen:
Common (1% to 10%): Nausea, dyspepsia, diarrhea, constipation, upper abdominal pain, gastroesophageal reflux disease, vomiting, stomach discomfort, abdominal pain

Famotidine:
Postmarketing reports: Nausea, diarrhea, vomiting, abdominal pain

Ibuprofen:
Common (1% to 10%): Nausea, dyspepsia, diarrhea, constipation, upper abdominal pain, gastroesophageal reflux disease, vomiting, stomach discomfort, abdominal pain[Ref]

Cardiovascular

Famotidine-Ibuprofen:
Common (1% to 10%): Hypertension

Famotidine:
Postmarketing reports: Hypotension

Ibuprofen:
Common (1% to 10%): Hypertension
Postmarketing reports: Myocardial infarction[Ref]

Renal

Famotidine-Ibuprofen:
Common (1% to 10%): Serum creatinine increased
Frequency not reported: Acute renal failure

Ibuprofen:
Common (1% to 10%): Serum creatinine increased
Postmarketing reports: Acute renal failure[Ref]

Hematologic

Famotidine-Ibuprofen:
Common (1% to 10%): Anemia

Famotidine:
Postmarketing reports: Anemia, thrombocytopenia, platelet count decreased, hemoglobin decreased

Ibuprofen:
Common (1% to 10%): Anemia[Ref]

Hepatic

Famotidine:
Postmarketing reports: Hepatic function abnormal, ALT increased, AST increased

Other

Famotidine-Ibuprofen:
Common (1% to 10%): Peripheral edema, influenza

Famotidine:
Postmarketing reports: Pyrexia, condition aggravated, asthenia, drug ineffective, chest pain, fatigue, pain, peripheral edema, sepsis

Ibuprofen:
Common (1% to 10%): Peripheral edema, influenza
Postmarketing reports: Pyrexia, pain, fatigue, asthenia, chest pain, drug ineffective[Ref]

Metabolic

Famotidine:
Postmarketing reports: Appetite decreased[Ref]

Musculoskeletal

Famotidine-Ibuprofen:
Common (1% to 10%): Arthralgia, back pain

Ibuprofen:
Common (1% to 10%): Arthralgia, back pain[Ref]

Nervous system

Famotidine-Ibuprofen:
Common (1% to 10%): Headache

Famotidine:
Postmarketing reports: Dizziness, headache

Ibuprofen:
Common (1% to 10%): Headache
Postmarketing reports: Dizziness[Ref]

Respiratory

Famotidine-Ibuprofen:
Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis, sinusitis, bronchitis, cough, pharyngolaryngeal pain

Famotidine:
Postmarketing reports: Pneumonia, dyspnea

Ibuprofen:
Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis, sinusitis, bronchitis, cough, pharyngolaryngeal pain
Postmarketing reports: Dyspnea[Ref]

Genitourinary

Famotidine-Ibuprofen:
Common (1% to 10%): Urinary tract infection

Ibuprofen:
Common (1% to 10%): Urinary tract infection[Ref]

Psychiatric

Ibuprofen:
Postmarketing reports: Depression, anxiety[Ref]

References

1. "Product Information. Duexis (famotidine-ibuprofen)." Horizon Pharma USA Inc, Northbrook, IL.

Some side effects of famotidine / ibuprofen may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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