Famotidine / Ibuprofen Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 1, 2024.

Applies to famotidine / ibuprofen: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits while you are using this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it. Blood and urine tests may be needed to check for unwanted effects.

Ibuprofen may increase your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk. Check with your doctor right away if you are having chest pain or discomfort, nausea or vomiting, pain or discomfort in the arms, jaw, back, or neck, trouble breathing, slurred speech, or weakness.

Ibuprofen may cause bleeding in your stomach or intestines. This problem can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years of age, are in poor health, or are using certain other medicines (eg, steroids or a blood thinner).

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Your blood pressure might get too high while you are using this medicine. This may cause headaches, dizziness, or blurred vision. You might need to measure your blood pressure at home. If you think your blood pressure is too high, call your doctor right away.

If you are rapidly gaining weight, trouble breathing, chest pain or discomfort, extreme tiredness or weakness, irregular breathing, irregular heartbeat, or excessive swelling of the hands, wrist, ankles, or feet, check with your doctor immediately. These may be symptoms of heart problems or your body keeping too much water.

Check with your doctor right away if you have blood in the urine, decrease in the frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These may be symptoms of a serious kidney problem.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, or weakness or heaviness of the legs.

This medicine may cause a serious allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Serious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS) can occur with this medicine. Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, fever, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots on the lips or in the mouth, swollen glands, unusual bleeding or bruising, or unusual tiredness and weakness.

Using this medicine during the later part of pregnancy can harm your unborn baby. If you think you have become pregnant while using this medicine, tell your doctor right away.

This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.

Some people who have used this medicine had symptoms of meningitis. If you have fever, headache, nausea, vomiting, and stiff neck or back while using this medicine, check with your doctor right away.

Check with your doctor right away if blurred vision, difficulty with reading, or any other change in vision occurs during or after your treatment. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor).

Before having any kind of surgery or medical tests, tell your doctor that you are using this medicine. It may be necessary for you to stop the medicine for a while, or to change to a different medicine before your procedure.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects

Along with its needed effects, famotidine / ibuprofen may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking famotidine / ibuprofen:

Other side effects

Some side effects of famotidine / ibuprofen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to famotidine / ibuprofen: oral tablet.

General adverse events

Famotidine-Ibuprofen:

The most frequently reported side effects included nausea, diarrhea, constipation, upper abdominal pain, and headache.^[Ref]

Gastrointestinal

Famotidine-Ibuprofen:

• Common (1% to 10%): Nausea, dyspepsia, diarrhea, constipation, upper abdominal pain, gastroesophageal reflux disease, vomiting, stomach discomfort, abdominal pain

Famotidine:

• Postmarketing reports: Nausea, diarrhea, vomiting, abdominal pain

Ibuprofen:

• Common (1% to 10%): Nausea, dyspepsia, diarrhea, constipation, upper abdominal pain, gastroesophageal reflux disease, vomiting, stomach discomfort, abdominal pain^[Ref]

Cardiovascular

Famotidine-Ibuprofen:

• Common (1% to 10%): Hypertension

Famotidine:

• Postmarketing reports: Hypotension

Ibuprofen:

• Common (1% to 10%): Hypertension
• Postmarketing reports: Myocardial infarction^[Ref]

Renal

Famotidine-Ibuprofen:

• Common (1% to 10%): Serum creatinine increased
• Frequency not reported: Acute renal failure

Ibuprofen:

• Common (1% to 10%): Serum creatinine increased
• Postmarketing reports: Acute renal failure^[Ref]

Hematologic

Famotidine-Ibuprofen:

• Common (1% to 10%): Anemia

Famotidine:

• Postmarketing reports: Anemia, thrombocytopenia, platelet count decreased, hemoglobin decreased

Ibuprofen:

• Common (1% to 10%): Anemia^[Ref]

Hepatic

Famotidine:

• Postmarketing reports: Hepatic function abnormal, ALT increased, AST increased

Other

Famotidine-Ibuprofen:

• Common (1% to 10%): Peripheral edema, influenza

Famotidine:

• Postmarketing reports: Pyrexia, condition aggravated, asthenia, drug ineffective, chest pain, fatigue, pain, peripheral edema, sepsis

Ibuprofen:

• Common (1% to 10%): Peripheral edema, influenza
• Postmarketing reports: Pyrexia, pain, fatigue, asthenia, chest pain, drug ineffective^[Ref]

Metabolic

Famotidine:

• Postmarketing reports: Appetite decreased^[Ref]

Musculoskeletal

Famotidine-Ibuprofen:

• Common (1% to 10%): Arthralgia, back pain

Ibuprofen:

• Common (1% to 10%): Arthralgia, back pain^[Ref]

Nervous system

Famotidine-Ibuprofen:

• Common (1% to 10%): Headache

Famotidine:

• Postmarketing reports: Dizziness, headache

Ibuprofen:

• Common (1% to 10%): Headache
• Postmarketing reports: Dizziness^[Ref]

Respiratory

Famotidine-Ibuprofen:

• Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis, sinusitis, bronchitis, cough, pharyngolaryngeal pain

Famotidine:

• Postmarketing reports: Pneumonia, dyspnea

Ibuprofen:

• Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis, sinusitis, bronchitis, cough, pharyngolaryngeal pain
• Postmarketing reports: Dyspnea^[Ref]

Genitourinary

Famotidine-Ibuprofen:

• Common (1% to 10%): Urinary tract infection

Ibuprofen:

• Common (1% to 10%): Urinary tract infection^[Ref]

Psychiatric

Ibuprofen:

• Postmarketing reports: Depression, anxiety^[Ref]

See also:

Further information

Famotidine/ibuprofen side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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