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Fenoprofen

Generic Name: fenoprofen (fen oh PROE fen)
Brand Name: Nalfon, Profeno

Medically reviewed by Drugs.com on Apr 2, 2020 – Written by Cerner Multum

What is fenoprofen?

Fenoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat mild to moderate pain, osteoarthritis, or rheumatoid arthritis.

Fenoprofen may also be used for purposes not listed in this medication guide.

Important Information

Fenoprofen can increase your risk of fatal heart attack or stroke. Do not use fenoprofen just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Fenoprofen may also cause stomach or intestinal bleeding, which can be fatal.

Before taking this medicine

Fenoprofen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Fenoprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using fenoprofen, especially in older adults.

You should not use fenoprofen if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Tell your doctor if you have ever had:

  • heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;

  • a heart attack, stroke, or blood clot;

  • stomach ulcers or bleeding;

  • asthma;

  • fluid retention;

  • liver or kidney disease; or

  • if you take aspirin to prevent heart attack or stroke.

Taking fenoprofen during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while using fenoprofen.

Fenoprofen is not approved for use by anyone younger than 18 years old.

How should I take fenoprofen?

Follow all directions on your prescription label and read all medication guides. Use the lowest dose that is effective in treating your condition.

You may take fenoprofen with food or milk.

If you use this medicine long-term, you may need frequent medical tests.

It may take up to 3 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using fenoprofen.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, vomiting, stomach pain, or stomach bleeding.

What should I avoid while taking fenoprofen?

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to fenoprofen (such as ibuprofen, ketoprofen, or naproxen).

Avoid taking aspirin unless your doctor tells you to.

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb fenoprofen.

Fenoprofen side effects

Get emergency medical help if you have signs of an allergic reaction (hives, runny or stuffy nose, wheezing, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, swelling in your legs, feeling short of breath.

Stop using fenoprofen and call your doctor at once if you have:

  • changes in your vision;

  • any skin rash, no matter how mild;

  • shortness of breath (even with mild exertion);

  • swelling or rapid weight gain;

  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • liver problems--nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired; or

  • low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed, cold hands and feet.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Fenoprofen dosing information

Usual Adult Dose for Osteoarthritis:

400 mg to 600 mg orally 3 or 4 times a day
-Maximum dose: 3200 mg/day

Comments:
-Dose adjustments should be made following initiation of therapy or during exacerbations of the disease.
-Patients with rheumatoid arthritis usually require larger doses than those with osteoarthritis; the lowest effective dose that yields acceptable control for either condition should be employed.

Use: For the relief of signs and symptoms of osteoarthritis and rheumatoid arthritis

Usual Adult Dose for Rheumatoid Arthritis:

400 mg to 600 mg orally 3 or 4 times a day
-Maximum dose: 3200 mg/day

Comments:
-Dose adjustments should be made following initiation of therapy or during exacerbations of the disease.
-Patients with rheumatoid arthritis usually require larger doses than those with osteoarthritis; the lowest effective dose that yields acceptable control for either condition should be employed.

Use: For the relief of signs and symptoms of osteoarthritis and rheumatoid arthritis

Usual Adult Dose for Pain:

200 mg orally every 4 to 6 hours as needed

Use: For the relief of mild to moderate pain

What other drugs will affect fenoprofen?

Ask your doctor before using fenoprofen if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect fenoprofen, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.