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Insomnia Medications (Sleeping Pills)

Other names: Difficulty sleeping; Dyssomnia; Inability to sleep; Sleeplessness; Wakefulness

Medications to treat insomnia include Belsomra, Ambien, Dayvigo, Quviviq, Lunesta, Restoril and many more.  Treatments for insomnia to help you sleep are available on prescription, and some are available OTC eg Unisom and ZzzQuil.

Drugs used for Insomnia

The medications listed below are related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
trazodone Off-label 6.2 888 reviews for trazodone to treat Insomnia
Rx C N X
Generic name:
trazodone systemic
Drug class:
phenylpiperazine antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Ambien 7.0 557 reviews for Ambien to treat Insomnia
Rx C 4 X
Generic name:
zolpidem systemic
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
zolpidem 6.9 1040 reviews for zolpidem to treat Insomnia
Rx C 4 X
Generic name:
zolpidem systemic
Brand names:
Ambien, Ambien CR, Edluar, Zolpimist
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Quviviq 4.3 124 reviews for Quviviq to treat Insomnia
Rx 4 X
Generic name:
daridorexant systemic
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
daridorexant 4.4 127 reviews for daridorexant to treat Insomnia
Rx 4 X
Generic name:
daridorexant systemic
Brand name:
Quviviq
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
temazepam 6.5 432 reviews for temazepam to treat Insomnia
Rx X 4 X
Generic name:
temazepam systemic
Brand name:
Restoril
Drug class:
benzodiazepines
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
amitriptyline Off-label 7.2 286 reviews for amitriptyline to treat Insomnia
Rx C N X
Generic name:
amitriptyline systemic
Drug class:
tricyclic antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
quetiapine Off-label 7.6 536 reviews for quetiapine to treat Insomnia
Rx C N X
Generic name:
quetiapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Lunesta 5.8 327 reviews for Lunesta to treat Insomnia
Rx C 4 X
Generic name:
eszopiclone systemic
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
mirtazapine Off-label 7.1 502 reviews for mirtazapine to treat Insomnia
Rx C N X
Generic name:
mirtazapine systemic
Drug class:
tetracyclic antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Ativan 7.6 40 reviews for Ativan to treat Insomnia
Rx D 4 X
Generic name:
lorazepam systemic
Drug class:
benzodiazepines, miscellaneous antiemetics, benzodiazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
clonazepam Off-label 7.3 201 reviews for clonazepam to treat Insomnia
Rx D 4 X
Generic name:
clonazepam systemic
Drug class:
benzodiazepines, benzodiazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
lorazepam 7.3 136 reviews for lorazepam to treat Insomnia
Rx D 4 X
Generic name:
lorazepam systemic
Brand name:
Ativan
Drug class:
benzodiazepines, miscellaneous antiemetics, benzodiazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Restoril 6.8 105 reviews for Restoril to treat Insomnia
Rx X 4 X
Generic name:
temazepam systemic
Drug class:
benzodiazepines
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
gabapentin Off-label 7.4 139 reviews for gabapentin to treat Insomnia
Rx C N X
Generic name:
gabapentin systemic
Drug class:
gamma-aminobutyric acid analogs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
estazolam 8.4 27 reviews for estazolam to treat Insomnia
Rx X 4 X
Generic name:
estazolam systemic
Drug class:
benzodiazepines
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
doxepin 5.7 310 reviews for doxepin to treat Insomnia
Rx N N X
Generic name:
doxepin systemic
Brand name:
Silenor
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics, tricyclic antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
flurazepam 8.4 121 reviews for flurazepam to treat Insomnia
Rx N 4 X
Generic name:
flurazepam systemic
Drug class:
benzodiazepines
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Belsomra 3.7 536 reviews for Belsomra to treat Insomnia
Rx C 4 X
Generic name:
suvorexant systemic
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Halcion 8.0 32 reviews for Halcion to treat Insomnia
Rx X 4 X
Generic name:
triazolam systemic
Drug class:
benzodiazepines
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
diphenhydramine 4.7 384 reviews for diphenhydramine to treat Insomnia
Rx/OTC B N X
Generic name:
diphenhydramine systemic
Brand names:
Compoz Nighttime Sleep Aid, Nytol, Simply Sleep, Sominex, Unisom SleepGels, Unisom SleepMelts, ZzzQuil, Dormin, Nytol QuickCaps, Sleep-ettes D, Sleepinal, Twilite, Z-Sleep
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics, antihistamines, anticholinergic antiemetics, anticholinergic antiparkinson agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Ambien CR 6.7 103 reviews for Ambien CR to treat Insomnia
Rx C 4 X
Generic name:
zolpidem systemic
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
eszopiclone 5.6 426 reviews for eszopiclone to treat Insomnia
Rx C 4 X
Generic name:
eszopiclone systemic
Brand name:
Lunesta
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Rozerem 4.4 103 reviews for Rozerem to treat Insomnia
Rx C N X
Generic name:
ramelteon systemic
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Silenor 6.2 122 reviews for Silenor to treat Insomnia
Rx N N X
Generic name:
doxepin systemic
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics, tricyclic antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information

Frequently asked questions

View more FAQ

Topics under Insomnia

Alternative treatments for Insomnia

The following products are considered to be alternative treatments or natural remedies for Insomnia. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However, there may be historical, cultural or anecdotal evidence linking their use to the treatment of Insomnia.

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.