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Painkiller Medications

The medications listed below are related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
diclofenac 6.9 275 reviews for diclofenac to treat Pain
Rx/OTC C N
Generic name:
diclofenac topical
Brand names:
Voltaren Arthritis Pain Gel, Flector Patch, Aspercreme Arthritis Pain Relief Gel, Licart, Xrylix
Drug class:
topical non-steroidal anti-inflammatories
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Voltaren Arthritis Pain Gel 7.1 154 reviews for Voltaren Arthritis Pain Gel to treat Pain
OTC C N
Generic name:
diclofenac topical
Drug class:
topical non-steroidal anti-inflammatories
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
lidocaine 4.6 144 reviews for lidocaine to treat Pain
Rx/OTC B N
Generic name:
lidocaine topical
Brand names:
Lidocaine Viscous, Aloe Vera Burn Relief Spray with Lidocaine, AneCream, Anestacon, Astero, Bactine, Bruselix Cream, Bruselix Gel, CidalEaze, DermacinRx Lidotral, DermacinRx Lido V Pak, Eha Lotion, Glydo, LidaMantle, Lidocan III, Lidocan Patch, Lidogel, Lidopac, LidoRx, Lidotrans 5 Pak, Lidozion, LMX 4, LMX 5, LTA II Kit, Lydexa, Medi-Quik Spray, Moxicaine, RadiaGuard, RectiCare, Regenecare HA Spray, Topicaine, Tranzarel, Xylocaine Jelly, Xylocaine Topical, Zionodil
Drug class:
topical anesthetics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
naproxen 6.1 103 reviews for naproxen to treat Pain
Rx/OTC C N X
Generic name:
naproxen systemic
Brand names:
Aleve, Naprosyn, Aflaxen, All Day Pain Relief, All Day Relief, Anaprox-DS, EC-Naprosyn, Flanax Pain Reliever, Midol Extended Relief, Naprelan
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
aspirin / caffeine 5.8 88 reviews for aspirin / caffeine to treat Pain
OTC N N X
Generic name:
aspirin / caffeine systemic
Brand names:
BC Original, Alka-Seltzer Wake-Up Call!, Anacin, Anacin Max Strength, Back & Body Extra Strength, Bayer Extra Strength Back & Body, BC Arthritis, BC Fast Pain Relief, Cope, P-A-C, P-A-C Analgesic
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
BC Original 5.6 71 reviews for BC Original to treat Pain
OTC N N X
Generic name:
aspirin / caffeine systemic
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
capsaicin 4.7 64 reviews for capsaicin to treat Pain
Rx/OTC B N
Generic name:
capsaicin topical
Brand names:
Aspercreme Warming Pain Relief Patch, Axsain, Capsagel Extra Strength, Capsin, Capzasin, Capzasin-HP, Capzasin-P, Capzasin Back and Body, Castiva Warming, Menthac Arthritis Cream with Capsaicin, Qutenza, Salonpas-Hot, Sloan's Liniment, Theragen HP, Zostrix, Zostrix Diabetic Foot Pain, Zostrix Neuropathy, Zostrix Sports
Drug class:
miscellaneous topical agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
acetaminophen 5.8 58 reviews for acetaminophen to treat Pain
Rx/OTC C N X
Generic name:
acetaminophen systemic
Brand names:
Tylenol, Paracetamol, Tylenol Arthritis Pain, Tylenol 8 Hour, Altenol, Arthritis Pain Relief, Cetafen, Dolono, Feverall, Mapap, Vitapap, 7T Gummy ES Chewable Tablets, Acephen, Actamin, Aminofen, Anacin Aspirin Free, Apra, Aurophen, Children's Silapap, Children's Tylenol, Febrol Solution, Genapap, Genebs, Infant's Tylenol, Jr. Tylenol, Leader 8 Hour Pain Reliever, M-Pap, Mapap Arthritis Pain, Nortemp Children's, Pharbetol, Silapap Childrens, Tactinal, Tempra Quicklets, Tycolene, Tylophen
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
ibuprofen 7.7 49 reviews for ibuprofen to treat Pain
Rx/OTC C N X
Generic name:
ibuprofen systemic
Brand names:
Advil, Motrin, Advil Liqui-Gels, Motrin IB, Proprinal, A-G Profen, Addaprin, Advil Children's, Advil Infant's Concentrated Drops, Advil Junior Strength, Advil Migraine, Caldolor, Children's Motrin, Genpril, IBU-200, Midol IB, Motrin Childrens, Motrin Infant Drops, Motrin Junior Strength, Nuprin
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
camphor / menthol 7.2 38 reviews for camphor / menthol to treat Pain
OTC N N
Generic name:
camphor / menthol topical
Brand names:
AleveX, Arctic Relief, Fast Freeze, Freeze It, Freeze It Roll-On, Sombra Warm Therapy, Tiger Balm, Tiger Balm Extra Strength, Tiger Balm Ultra Strength
Drug class:
topical rubefacient
For consumers:
dosage, side effects
trolamine salicylate 6.6 36 reviews for trolamine salicylate to treat Pain
OTC N N
Generic name:
trolamine salicylate topical
Brand names:
Arthricream, Asper-Flex, Myoflex, Tru-micin, Ultracin T
Drug class:
topical rubefacient
For consumers:
dosage, side effects
Tiger Balm 7.4 28 reviews for Tiger Balm to treat Pain
OTC N N
Generic name:
camphor / menthol topical
Drug class:
topical rubefacient
For consumers:
dosage, side effects
Aleve 6.1 26 reviews for Aleve to treat Pain
Rx/OTC C N X
Generic name:
naproxen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
menthol 5.2 26 reviews for menthol to treat Pain
Rx/OTC N N
Generic name:
menthol topical
Brand names:
Biofreeze, ActivICE, Aspercreme Max No Mess Roll-On, Aspercreme Pain Relieving Heat Gel, Bengay Cold Therapy Gel, Bengay Ultra Strength Pain Relieving Patch, BENGAY Vanishing Scent, Bengay Zero Degrees, Blue-Emu Maximum Strength Arthritis, Muscle & Joint Pain Relief, Blue Gel, Cool 'n Heat Patch, Flexall, Gold Bond Medicated Maximum Strength Foot, Icy Hot Advanced Relief Pain Relief Patch, Icy Hot Extra Strength, Icy Hot Medicated Spray, Icy Hot Vanishing Scent Pain Relieving Gel, Max-Freeze, Mineral Ice, Sombra Cool Therapy, Stopain, Therapeutic Ice
Drug class:
topical rubefacient
For consumers:
dosage, side effects
magnesium salicylate 9.3 19 reviews for magnesium salicylate to treat Pain
Rx/OTC C N X
Generic name:
magnesium salicylate systemic
Brand names:
Doan's Pills, Doans Pills Extra Strength, MST, Nuprin Backache
Drug class:
salicylates
For consumers:
interactions, side effects
Tylenol 5.9 18 reviews for Tylenol to treat Pain
Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
acetaminophen / diphenhydramine 8.4 17 reviews for acetaminophen / diphenhydramine to treat Pain
OTC N N X
Generic name:
acetaminophen / diphenhydramine systemic
Brand names:
Tylenol PM, Headache Relief PM, Legatrin PM, Midol PM, Percogesic Extra Strength, Percogesic Original Strength
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
ketoprofen 9.9 17 reviews for ketoprofen to treat Pain
Rx/OTC C N X
Generic name:
ketoprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
diphenhydramine / naproxen 6.0 16 reviews for diphenhydramine / naproxen to treat Pain
OTC C N X
Generic name:
diphenhydramine / naproxen systemic
Brand name:
Aleve PM
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
Aleve PM 6.3 15 reviews for Aleve PM to treat Pain
OTC C N X
Generic name:
diphenhydramine / naproxen systemic
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
aspirin 6.7 12 reviews for aspirin to treat Pain
Rx/OTC N N X
Generic name:
aspirin systemic
Brand names:
Arthritis Pain, Bayer Aspirin, Ecotrin, Ascriptin, Aspergum, Aspiritab, Aspirtab, Bayer Aspirin Extra Strength Plus, Easprin, Ecpirin, Entercote, Genacote, Halfprin, Norwich Aspirin, Vazalore
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Doans Pills Extra Strength 9.7 8 reviews for Doans Pills Extra Strength to treat Pain
Rx/OTC C N X
Generic name:
magnesium salicylate systemic
Drug class:
salicylates
For consumers:
interactions, side effects
Paracetamol 4.1 8 reviews for Paracetamol to treat Pain
Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Percogesic Original Strength 9.5 8 reviews for Percogesic Original Strength to treat Pain
OTC N N X
Generic name:
acetaminophen / diphenhydramine systemic
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
Tylenol 8 Hour 8.0 8 reviews for Tylenol 8 Hour to treat Pain
Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects

Frequently asked questions

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Topics under Pain

Alternative treatments for Pain

The following products are considered to be alternative treatments or natural remedies for Pain. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However, there may be historical, cultural or anecdotal evidence linking their use to the treatment of Pain.

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.